5mxs - Revision history

OCA at 10:19, 14 June 2023

OCA — Wed, 14 Jun 2023 10:19:28 GMT

←Older revision		Revision as of 10:19, 14 June 2023
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	==Peptide-membrane interaction between targeting and lysis==		==Peptide-membrane interaction between targeting and lysis==
-	<StructureSection load='5mxs' size='340' side='right'caption='[[5mxs~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5mxs' size='340' side='right'caption='[[5mxs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MXS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxs OCA], [~~http~~://pdbe.org/5mxs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mxs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mxs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxs OCA], [https://pdbe.org/5mxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mxs RCSB], [https://www.ebi.ac.uk/pdbsum/5mxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Synthetic construct ~~sequences~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Blatter, M]]	+	[[Category: Blatter M]]
-	~~[[Category: Protein~~]]	+

OCA at 13:11, 10 May 2019

OCA — Fri, 10 May 2019 13:11:56 GMT

←Older revision		Revision as of 13:11, 10 May 2019
Line 1:		Line 1:

	==Peptide-membrane interaction between targeting and lysis==		==Peptide-membrane interaction between targeting and lysis==
-	<StructureSection load='5mxs' size='340' side='right' caption='[[5mxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5mxs' size='340' side='right'caption='[[5mxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXS FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Synthetic construct sequences]]		[[Category: Synthetic construct sequences]]
	[[Category: Blatter, M]]		[[Category: Blatter, M]]
	[[Category: Protein]]		[[Category: Protein]]

OCA at 08:00, 14 June 2018

OCA — Thu, 14 Jun 2018 08:00:59 GMT

←Older revision		Revision as of 08:00, 14 June 2018
Line 3:		Line 3:
	<StructureSection load='5mxs' size='340' side='right' caption='[[5mxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='5mxs' size='340' side='right' caption='[[5mxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxs OCA], [http://pdbe.org/5mxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxs RCSB], [http://www.ebi.ac.uk/pdbsum/5mxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxs OCA], [http://pdbe.org/5mxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxs RCSB], [http://www.ebi.ac.uk/pdbsum/5mxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxs ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Certain cationic peptides interact with biological membranes. These often-complex interactions can result in peptide targeting to the membrane, or in membrane permeation, rupture, and cell lysis. We investigated the relationship between the structural features of membrane-active peptides and these effects, to better understand these processes. To this end, we employed a computational method for morphing a membranolytic antimicrobial peptide into a nonmembranolytic mitochondrial targeting peptide by "directed simulated evolution." The results obtained demonstrate that superficially subtle sequence modifications can strongly affect the peptides' membranolytic and membrane-targeting abilities. Spectroscopic and computational analyses suggest that N- and C-terminal structural flexibility plays a crucial role in determining the mode of peptide-membrane interaction.
		+
		+	Peptide-Membrane Interaction between Targeting and Lysis.,Stutz K, Muller AT, Hiss JA, Schneider P, Blatter M, Pfeiffer B, Posselt G, Kanfer G, Kornmann B, Wrede P, Altmann KH, Wessler S, Schneider G ACS Chem Biol. 2017 Aug 8. doi: 10.1021/acschembio.7b00504. PMID:28763193<ref>PMID:28763193</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5mxs" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Synthetic construct sequences]]
	[[Category: Blatter, M]]		[[Category: Blatter, M]]
	[[Category: Protein]]		[[Category: Protein]]

OCA at 01:40, 11 March 2017

OCA — Sat, 11 Mar 2017 01:40:35 GMT

←Older revision		Revision as of 01:40, 11 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5mxs is ON HOLD~~	+	==Peptide-membrane interaction between targeting and lysis==
-		+	<StructureSection load='5mxs' size='340' side='right' caption='[[5mxs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors: Blatter, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mxs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXS FirstGlance]. <br>
-	~~Description:~~ Peptide-membrane interaction between targeting and lysis	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxs OCA], [http://pdbe.org/5mxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxs RCSB], [http://www.ebi.ac.uk/pdbsum/5mxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxs ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Blatter, M]]		[[Category: Blatter, M]]
		+	[[Category: Protein]]

OCA: Protected "5mxs" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2017 15:22:20 GMT

Protected "5mxs" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:22, 1 February 2017

OCA: New page: '''Unreleased structure''' The entry 5mxs is ON HOLD Authors: Blatter, M. Description: Peptide-membrane interaction between targeting and lysis Category: Unreleased Structures [[Ca...

OCA — Wed, 01 Feb 2017 15:22:19 GMT

New page: '''Unreleased structure''' The entry 5mxs is ON HOLD Authors: Blatter, M. Description: Peptide-membrane interaction between targeting and lysis Category: Unreleased Structures [[Ca...

New page

'''Unreleased structure'''

The entry 5mxs is ON HOLD

Authors: Blatter, M.

Description: Peptide-membrane interaction between targeting and lysis
[[Category: Unreleased Structures]]
[[Category: Blatter, M]]