5mzb - Revision history

OCA: Redirecting to 6r3t

OCA — Wed, 10 Apr 2019 06:59:38 GMT

Redirecting to 6r3t

←Older revision		Revision as of 06:59, 10 April 2019
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-		+	#REDIRECT [[6r3t]] This PDB entry is obsolete and replaced by 6r3t
-	~~==Structure of P110 from Mycoplasma Genitalium at 2.7A==~~	+
-	~~<StructureSection load='5mzb' size='340' side='right' caption='~~[[~~5mzb]], [[Resolution\|resolution]] 2.73Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[5mzb~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycge Mycge]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZB FirstGlance]. <br>	+
-	~~</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MG192 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243273 MYCGE])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzb OCA], [http://pdbe.org/5mzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzb RCSB], [http://www.ebi.ac.uk/pdbsum/5mzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzb ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization~~ and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. Herein, we present the crystal structures of the extracellular region of the virulence factor P110 (916 residues) unliganded and in complex with sialic acid oligosaccharides. P110 interacts only with the neuraminic acid moiety of the oligosaccharides and experiments with human cells demonstrate that these interactions are essential for mycoplasma cytadherence. Additionally, structural information provides a deep insight of the P110 antigenic regions undergoing programmed variation to evade the host immune response. These results enlighten the interplay of M. genitalium with human target cells, offering new strategies to control mycoplasma infections.	+
-		+
-	Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors.,Aparicio D, Torres-Puig S, Ratera M, Querol E, Pinol J, Pich OQ, Fita I Nat Commun. 2018 Oct 26;9(1):4471. doi: 10.1038/s41467-018-06963-y. PMID:30367053<ref>PMID:30367053</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 5mzb" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Mycge]]~~	+
-	~~[[Category: Aparicio, D]]~~	+
-	~~[[Category: Fita, I]]~~	+
-	~~[[Category: Unknown function]]~~	+

OCA at 12:31, 7 November 2018

OCA — Wed, 07 Nov 2018 12:31:52 GMT

←Older revision		Revision as of 12:31, 7 November 2018
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzb OCA], [http://pdbe.org/5mzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzb RCSB], [http://www.ebi.ac.uk/pdbsum/5mzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzb OCA], [http://pdbe.org/5mzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzb RCSB], [http://www.ebi.ac.uk/pdbsum/5mzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzb ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. Herein, we present the crystal structures of the extracellular region of the virulence factor P110 (916 residues) unliganded and in complex with sialic acid oligosaccharides. P110 interacts only with the neuraminic acid moiety of the oligosaccharides and experiments with human cells demonstrate that these interactions are essential for mycoplasma cytadherence. Additionally, structural information provides a deep insight of the P110 antigenic regions undergoing programmed variation to evade the host immune response. These results enlighten the interplay of M. genitalium with human target cells, offering new strategies to control mycoplasma infections.
		+
		+	Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors.,Aparicio D, Torres-Puig S, Ratera M, Querol E, Pinol J, Pich OQ, Fita I Nat Commun. 2018 Oct 26;9(1):4471. doi: 10.1038/s41467-018-06963-y. PMID:30367053<ref>PMID:30367053</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5mzb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:24, 17 October 2018

OCA — Wed, 17 Oct 2018 08:24:45 GMT

←Older revision		Revision as of 08:24, 17 October 2018
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-	==Mycoplasma Genitalium ~~Protein B~~==	+	==Structure of P110 from Mycoplasma Genitalium at 2.7A==
	<StructureSection load='5mzb' size='340' side='right' caption='[[5mzb]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='5mzb' size='340' side='right' caption='[[5mzb]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycge Mycge]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MG192 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243273 MYCGE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzb OCA], [http://pdbe.org/5mzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzb RCSB], [http://www.ebi.ac.uk/pdbsum/5mzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzb OCA], [http://pdbe.org/5mzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzb RCSB], [http://www.ebi.ac.uk/pdbsum/5mzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzb ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mycge]]
	[[Category: Aparicio, D]]		[[Category: Aparicio, D]]
	[[Category: Fita, I]]		[[Category: Fita, I]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 07:27, 12 September 2018

OCA — Wed, 12 Sep 2018 07:27:21 GMT

←Older revision		Revision as of 07:27, 12 September 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5mzb is ~~ON HOLD until Paper Publication~~	+	==Mycoplasma Genitalium Protein B==
-		+	<StructureSection load='5mzb' size='340' side='right' caption='[[5mzb]], [[Resolution\|resolution]] 2.73Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mzb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzb OCA], [http://pdbe.org/5mzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzb RCSB], [http://www.ebi.ac.uk/pdbsum/5mzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzb ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aparicio, D]]
		+	[[Category: Fita, I]]
		+	[[Category: Unknown function]]

OCA: Protected "5mzb" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 11:49:37 GMT

Protected "5mzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:49, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5mzb is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Mar 2017 11:49:36 GMT

New page: '''Unreleased structure''' The entry 5mzb is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mzb is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]