5mzu - Revision history

OCA at 17:55, 8 November 2023

OCA — Wed, 08 Nov 2023 17:55:12 GMT

←Older revision		Revision as of 17:55, 8 November 2023
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	<StructureSection load='5mzu' size='340' side='right'caption='[[5mzu]], [[Resolution\|resolution]] 3.80Å' scene=''>		<StructureSection load='5mzu' size='340' side='right'caption='[[5mzu]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MZU FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[4i2z\|4i2z]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzu OCA], [~~http~~://pdbe.org/5mzu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mzu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mzu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzu OCA], [https://pdbe.org/5mzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mzu RCSB], [https://www.ebi.ac.uk/pdbsum/5mzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G5EG62_CAEEL G5EG62_CAEEL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Clausen, T]]	+	[[Category: Clausen T]]
-	[[Category: Gazda, L]]	+	[[Category: Gazda L]]
-	[[Category: Hellerschmied, D]]	+	[[Category: Hellerschmied D]]
-	~~[[Category: Arm repeat]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Myosin folding]]~~	+
-	~~[[Category: Protein filament]]~~	+
-	~~[[Category: Ucs domain~~]]	+

OCA at 07:33, 19 August 2020

OCA — Wed, 19 Aug 2020 07:33:18 GMT

←Older revision		Revision as of 07:33, 19 August 2020
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	==Crystal structure of the myosin chaperone UNC-45 from C. elegans (alternative conformation)==		==Crystal structure of the myosin chaperone UNC-45 from C. elegans (alternative conformation)==
-	<StructureSection load='5mzu' size='340' side='right' caption='[[5mzu]], [[Resolution\|resolution]] 3.80Å' scene=''>	+	<StructureSection load='5mzu' size='340' side='right'caption='[[5mzu]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MZU FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i2z\|4i2z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i2z\|4i2z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzu OCA], [http://pdbe.org/5mzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzu RCSB], [http://www.ebi.ac.uk/pdbsum/5mzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzu OCA], [http://pdbe.org/5mzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzu RCSB], [http://www.ebi.ac.uk/pdbsum/5mzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Clausen, T]]		[[Category: Clausen, T]]
	[[Category: Gazda, L]]		[[Category: Gazda, L]]

OCA at 06:22, 15 February 2018

OCA — Thu, 15 Feb 2018 06:22:55 GMT

←Older revision		Revision as of 06:22, 15 February 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5mzu is ~~ON HOLD~~	+	==Crystal structure of the myosin chaperone UNC-45 from C. elegans (alternative conformation)==
		+	<StructureSection load='5mzu' size='340' side='right' caption='[[5mzu]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mzu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZU FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i2z\|4i2z]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzu OCA], [http://pdbe.org/5mzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzu RCSB], [http://www.ebi.ac.uk/pdbsum/5mzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzu ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Muscle development requires the coordinated activities of specific protein folding and degradation factors. UFD-2, a U-box ubiquitin ligase, has been reported to play a central role in this orchestra regulating the myosin chaperone UNC-45. Here, we apply an integrative in vitro and in vivo approach to delineate the substrate-targeting mechanism of UFD-2 and elucidate its distinct mechanistic features as an E3/E4 enzyme. Using Caenorhabditis elegans as model system, we demonstrate that UFD-2 is not regulating the protein levels of UNC-45 in muscle cells, but rather shows the characteristic properties of a bona fide E3 ligase involved in protein quality control. Our data demonstrate that UFD-2 preferentially targets unfolded protein segments. Moreover, the UNC-45 chaperone can serve as an adaptor protein of UFD-2 to poly-ubiquitinate unfolded myosin, pointing to a possible role of the UFD-2/UNC-45 pair in maintaining proteostasis in muscle cells.

-	~~Authors: Hellerschmied~~, D., ~~Gazda~~, L., ~~Clausen~~, T.	+	UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.,Hellerschmied D, Roessler M, Lehner A, Gazda L, Stejskal K, Imre R, Mechtler K, Dammermann A, Clausen T Nat Commun. 2018 Feb 2;9(1):484. doi: 10.1038/s41467-018-02924-7. PMID:29396393<ref>PMID:29396393</ref>

-	~~Description: Crystal structure~~ of the ~~myosin chaperone UNC-45 from C~~. ~~elegans (alternative conformation)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5mzu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Clausen, T]]		[[Category: Clausen, T]]
	[[Category: Gazda, L]]		[[Category: Gazda, L]]
	[[Category: Hellerschmied, D]]		[[Category: Hellerschmied, D]]
		+	[[Category: Arm repeat]]
		+	[[Category: Chaperone]]
		+	[[Category: Myosin folding]]
		+	[[Category: Protein filament]]
		+	[[Category: Ucs domain]]

OCA: Protected "5mzu" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 11:50:41 GMT

Protected "5mzu" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:50, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5mzu is ON HOLD Authors: Hellerschmied, D., Gazda, L., Clausen, T. Description: Crystal structure of the myosin chaperone UNC-45 from C. elegans (a...

OCA — Thu, 09 Mar 2017 11:50:40 GMT

New page: '''Unreleased structure''' The entry 5mzu is ON HOLD Authors: Hellerschmied, D., Gazda, L., Clausen, T. Description: Crystal structure of the myosin chaperone UNC-45 from C. elegans (a...

New page

'''Unreleased structure'''

The entry 5mzu is ON HOLD

Authors: Hellerschmied, D., Gazda, L., Clausen, T.

Description: Crystal structure of the myosin chaperone UNC-45 from C. elegans (alternative conformation)
[[Category: Unreleased Structures]]
[[Category: Clausen, T]]
[[Category: Gazda, L]]
[[Category: Hellerschmied, D]]