5n1i - Revision history

OCA at 07:48, 7 February 2024

OCA — Wed, 07 Feb 2024 07:48:27 GMT

←Older revision		Revision as of 07:48, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5n1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N1I FirstGlance]. <br>		<table><tr><td colspan='2'>[[5n1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N1I FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1i OCA], [https://pdbe.org/5n1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n1i RCSB], [https://www.ebi.ac.uk/pdbsum/5n1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1i ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1i OCA], [https://pdbe.org/5n1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n1i RCSB], [https://www.ebi.ac.uk/pdbsum/5n1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/O53623_MYCTU O53623_MYCTU]		[https://www.uniprot.org/uniprot/O53623_MYCTU O53623_MYCTU]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread worldwide. Some key antituberculosis antibiotics are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway in which resistance mutations have now been observed. The first-of-its-kind molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethionamide-resistant infection in mice, it also increases the basal sensitivity of bacteria to ethionamide.
-
-	Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.,Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K, Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkonig A, Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P, Gitzinger M, Deprez B, Willand N, Baulard AR Science. 2017 Mar 17;355(6330):1206-1211. doi: 10.1126/science.aag1006. Epub 2017, Mar 16. PMID:28302858<ref>PMID:28302858</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5n1i" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:31, 15 February 2023

OCA — Wed, 15 Feb 2023 10:31:37 GMT

←Older revision		Revision as of 10:31, 15 February 2023
Line 1:		Line 1:

	==unliganded form of the Mycobacterium tuberculosis repressor EthR2==		==unliganded form of the Mycobacterium tuberculosis repressor EthR2==
-	<StructureSection load='5n1i' size='340' side='right' caption='[[5n1i]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5n1i' size='340' side='right'caption='[[5n1i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n1i]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5N1I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N1I FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5n1c\|5n1c]], [[5icj\|5icj]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1i OCA], [https://pdbe.org/5n1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n1i RCSB], [https://www.ebi.ac.uk/pdbsum/5n1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1i ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv0078, LH57_00450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1i OCA], [~~http~~://pdbe.org/5n1i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5n1i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5n1i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1i ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O53623_MYCTU O53623_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Myctu~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wintjens, R~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: ~~Wohlkonig, A~~]]	+	[[Category: Wintjens R]]
-	[[Category: ~~Dna binding protein]]~~	+	[[Category: Wohlkonig A]]
-	~~[[Category: Ethr]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Tetr protein family~~]]	+

OCA at 07:28, 13 December 2017

OCA — Wed, 13 Dec 2017 07:28:16 GMT

←Older revision		Revision as of 07:28, 13 December 2017
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	<StructureSection load='5n1i' size='340' side='right' caption='[[5n1i]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5n1i' size='340' side='right' caption='[[5n1i]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n1i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N1I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n1i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N1I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5n1c\|5n1c]], [[5icj\|5icj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5n1c\|5n1c]], [[5icj\|5icj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv0078, LH57_00450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1i OCA], [http://pdbe.org/5n1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1i RCSB], [http://www.ebi.ac.uk/pdbsum/5n1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1i OCA], [http://pdbe.org/5n1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1i RCSB], [http://www.ebi.ac.uk/pdbsum/5n1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1i ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Myctu]]
	[[Category: Wintjens, R]]		[[Category: Wintjens, R]]
	[[Category: Wohlkonig, A]]		[[Category: Wohlkonig, A]]

OCA at 13:48, 27 April 2017

OCA — Thu, 27 Apr 2017 13:48:30 GMT

←Older revision		Revision as of 13:48, 27 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5n1i is ~~ON HOLD until Paper~~ Publication	+	==unliganded form of the Mycobacterium tuberculosis repressor EthR2==
		+	<StructureSection load='5n1i' size='340' side='right' caption='[[5n1i]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5n1i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N1I FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5n1c\|5n1c]], [[5icj\|5icj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1i OCA], [http://pdbe.org/5n1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1i RCSB], [http://www.ebi.ac.uk/pdbsum/5n1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1i ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread worldwide. Some key antituberculosis antibiotics are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway in which resistance mutations have now been observed. The first-of-its-kind molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethionamide-resistant infection in mice, it also increases the basal sensitivity of bacteria to ethionamide.

-	~~Authors: Wintjens~~, R., ~~Wohlkonig~~, A.	+	Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.,Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K, Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkonig A, Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P, Gitzinger M, Deprez B, Willand N, Baulard AR Science. 2017 Mar 17;355(6330):1206-1211. doi: 10.1126/science.aag1006. Epub 2017, Mar 16. PMID:28302858<ref>PMID:28302858</ref>

-	~~Description: unliganded form~~ of the ~~Mycobacterium tuberculosis repressor EthR2~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5n1i" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Wintjens, R]]		[[Category: Wintjens, R]]
	[[Category: Wohlkonig, A]]		[[Category: Wohlkonig, A]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Ethr]]
		+	[[Category: Repressor]]
		+	[[Category: Tetr protein family]]

OCA: Protected "5n1i" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 11:54:57 GMT

Protected "5n1i" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:54, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5n1i is ON HOLD until Paper Publication Authors: Wintjens, R., Wohlkonig, A. Description: unliganded form of the Mycobacterium tuberculosis repress...

OCA — Thu, 09 Mar 2017 11:54:56 GMT

New page: '''Unreleased structure''' The entry 5n1i is ON HOLD until Paper Publication Authors: Wintjens, R., Wohlkonig, A. Description: unliganded form of the Mycobacterium tuberculosis repress...

New page

'''Unreleased structure'''

The entry 5n1i is ON HOLD until Paper Publication

Authors: Wintjens, R., Wohlkonig, A.

Description: unliganded form of the Mycobacterium tuberculosis repressor EthR2
[[Category: Unreleased Structures]]
[[Category: Wintjens, R]]
[[Category: Wohlkonig, A]]