5n1w - Revision history

OCA at 17:57, 8 November 2023

OCA — Wed, 08 Nov 2023 17:57:34 GMT

←Older revision		Revision as of 17:57, 8 November 2023
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	<StructureSection load='5n1w' size='340' side='right'caption='[[5n1w]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5n1w' size='340' side='right'caption='[[5n1w]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n1w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5N1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n1w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N1W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HB:(2~{S})-2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-3,3-DIMETHYL-2-OXIDANYL-BUTANOYL]AMINO]PROPANOYLAMINO]ETHYLSULFANYL]PROPANOIC+ACID'>8HB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1w OCA], [~~http~~://pdbe.org/5n1w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5n1w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5n1w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1w ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HB:(2~{S})-2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-3,3-DIMETHYL-2-OXIDANYL-BUTANOYL]AMINO]PROPANOYLAMINO]ETHYLSULFANYL]PROPANOIC+ACID'>8HB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1w OCA], [https://pdbe.org/5n1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n1w RCSB], [https://www.ebi.ac.uk/pdbsum/5n1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1w ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8QZK6_XENLA A8QZK6_XENLA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chao, W C.H~~]]	+	[[Category: Xenopus laevis]]
-	[[Category: ~~Singleton, M R~~]]	+	[[Category: Chao WCH]]
-	[[Category: ~~Wade, B O~~]]	+	[[Category: Singleton MR]]
-	[[Category: ~~Cell cycle~~]]	+	[[Category: Wade BO]]

OCA at 11:56, 26 August 2020

OCA — Wed, 26 Aug 2020 11:56:07 GMT

←Older revision		Revision as of 11:56, 26 August 2020
Line 1:		Line 1:

	==Structure of xEco2 acetyltransferase domain bound to K105-CoA conjugate==		==Structure of xEco2 acetyltransferase domain bound to K105-CoA conjugate==
-	<StructureSection load='5n1w' size='340' side='right' caption='[[5n1w]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5n1w' size='340' side='right'caption='[[5n1w]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n1w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1W OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5N1W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n1w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5N1W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8HB:(2~{S})-2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-3,3-DIMETHYL-2-OXIDANYL-BUTANOYL]AMINO]PROPANOYLAMINO]ETHYLSULFANYL]PROPANOIC+ACID'>8HB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HB:(2~{S})-2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-3,3-DIMETHYL-2-OXIDANYL-BUTANOYL]AMINO]PROPANOYLAMINO]ETHYLSULFANYL]PROPANOIC+ACID'>8HB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1w OCA], [http://pdbe.org/5n1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1w RCSB], [http://www.ebi.ac.uk/pdbsum/5n1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1w OCA], [http://pdbe.org/5n1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1w RCSB], [http://www.ebi.ac.uk/pdbsum/5n1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chao, W C.H]]		[[Category: Chao, W C.H]]
	[[Category: Singleton, M R]]		[[Category: Singleton, M R]]
	[[Category: Wade, B O]]		[[Category: Wade, B O]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 07:02, 29 March 2017

OCA — Wed, 29 Mar 2017 07:02:11 GMT

←Older revision		Revision as of 07:02, 29 March 2017
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1w OCA], [http://pdbe.org/5n1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1w RCSB], [http://www.ebi.ac.uk/pdbsum/5n1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1w OCA], [http://pdbe.org/5n1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1w RCSB], [http://www.ebi.ac.uk/pdbsum/5n1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1w ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sister-chromatid cohesion is established by Eco1-mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit. However, the molecular basis of Eco1 substrate recognition and acetylation in cohesion is not fully understood. Here, we discover and rationalize the substrate specificity of Eco1 using mass spectrometry coupled with in-vitro acetylation assays and crystallography. Our structures of the X. laevis Eco2 (xEco2) bound to its primary and secondary Smc3 substrates demonstrate the plasticity of the substrate-binding site, which confers substrate specificity by concerted conformational changes of the central beta hairpin and the C-terminal extension.
		+
		+	Structural Basis of Eco1-Mediated Cohesin Acetylation.,Chao WC, Wade BO, Bouchoux C, Jones AW, Purkiss AG, Federico S, O'Reilly N, Snijders AP, Uhlmann F, Singleton MR Sci Rep. 2017 Mar 14;7:44313. doi: 10.1038/srep44313. PMID:28290497<ref>PMID:28290497</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5n1w" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:21, 15 March 2017

OCA — Wed, 15 Mar 2017 21:21:30 GMT

←Older revision		Revision as of 21:21, 15 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5n1w is ~~ON HOLD until Paper Publication~~	+	==Structure of xEco2 acetyltransferase domain bound to K105-CoA conjugate==
-		+	<StructureSection load='5n1w' size='340' side='right' caption='[[5n1w]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~: ~~Chao~~, W.C.H., ~~Wade~~, B.O., ~~Singleton~~, M.R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5n1w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N1W FirstGlance]. <br>
-	~~Description: Structure of xEco2 acetyltransferase domain bound to K105-CoA conjugate~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8HB:(2~{S})-2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-3,3-DIMETHYL-2-OXIDANYL-BUTANOYL]AMINO]PROPANOYLAMINO]ETHYLSULFANYL]PROPANOIC+ACID'>8HB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1w OCA], [http://pdbe.org/5n1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1w RCSB], [http://www.ebi.ac.uk/pdbsum/5n1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1w ProSAT]</span></td></tr>
-	[[Category: ~~Chao~~, ~~W.C.H~~]]	+	</table>
-	[[Category: Wade, B.O]]	+	__TOC__
-	[[Category: ~~Singleton, M.R~~]]	+	</StructureSection>
		+	[[Category: Chao, W C.H]]
		+	[[Category: Singleton, M R]]
		+	[[Category: Wade, B O]]
		+	[[Category: Cell cycle]]

OCA: Protected "5n1w" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 11:56:01 GMT

Protected "5n1w" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:56, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5n1w is ON HOLD until Paper Publication Authors: Chao, W.C.H., Wade, B.O., Singleton, M.R. Description: Structure of xEco2 acetyltransferase domain...

OCA — Thu, 09 Mar 2017 11:55:59 GMT

New page: '''Unreleased structure''' The entry 5n1w is ON HOLD until Paper Publication Authors: Chao, W.C.H., Wade, B.O., Singleton, M.R. Description: Structure of xEco2 acetyltransferase domain...

New page

'''Unreleased structure'''

The entry 5n1w is ON HOLD until Paper Publication

Authors: Chao, W.C.H., Wade, B.O., Singleton, M.R.

Description: Structure of xEco2 acetyltransferase domain bound to K105-CoA conjugate
[[Category: Unreleased Structures]]
[[Category: Chao, W.C.H]]
[[Category: Wade, B.O]]
[[Category: Singleton, M.R]]