5nfd - Revision history

OCA at 12:53, 15 November 2023

OCA — Wed, 15 Nov 2023 12:53:15 GMT

←Older revision		Revision as of 12:53, 15 November 2023
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	==Antiparallel monomeric coiled coil of Kif21A==		==Antiparallel monomeric coiled coil of Kif21A==
-	<StructureSection load='5nfd' size='340' side='right' caption='[[5nfd]], [[Resolution\|resolution]] 2.18Å' scene=''>	+	<StructureSection load='5nfd' size='340' side='right'caption='[[5nfd]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nfd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NFD FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~KIF21A~~, ~~KIAA1708, KIF2 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.18Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfd OCA], [~~http~~://pdbe.org/5nfd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nfd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nfd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfd OCA], [https://pdbe.org/5nfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nfd RCSB], [https://www.ebi.ac.uk/pdbsum/5nfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Congenital fibrosis of extraocular muscles. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN] Congenital fibrosis of extraocular muscles. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).	+	[https://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN] Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Bianchi, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kraatz,~~ S ~~H.W~~]]	+	[[Category: Bianchi S]]
-	[[Category: ~~Steinmetz, M O~~]]	+	[[Category: Kraatz SHW]]
-	[[Category: ~~Coiled coil]]~~	+	[[Category: Steinmetz MO]]
-	~~[[Category: Kinesin]]~~	+
-	~~[[Category: Motor protein~~]]	+

OCA at 10:20, 5 September 2018

OCA — Wed, 05 Sep 2018 10:20:39 GMT

←Older revision		Revision as of 10:20, 5 September 2018
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	<StructureSection load='5nfd' size='340' side='right' caption='[[5nfd]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='5nfd' size='340' side='right' caption='[[5nfd]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nfd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nfd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NFD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfd OCA], [http://pdbe.org/5nfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nfd RCSB], [http://www.ebi.ac.uk/pdbsum/5nfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfd ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIF21A, KIAA1708, KIF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfd OCA], [http://pdbe.org/5nfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nfd RCSB], [http://www.ebi.ac.uk/pdbsum/5nfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 10:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).		[[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Coiled coils are ubiquitous protein-protein interaction motifs found in many eukaryotic proteins. The elongated, flexible and often irregular natureof coiled coils together with their tendency to form fibrous arrangements in crystals impose challenges on solving the phase problem by molecular replacement. Here, we report the successful combinatorial use of native- and rational engineered disulfide bridges together with sulfur-SAD phasing as a powerful tool to stabilize and solve the structure of coiled-coil domains in a straightforward manner. Our study is a key example of how modern sulfur SAD combined with mutagenesis can help to advance and simplify the structural study of challenging coiled-coil domains by X-ray crystallography.
		+
		+	Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils.,Kraatz SHW, Bianchi S, Steinmetz MO Biosci Rep. 2018 Aug 22. pii: BSR20181073. doi: 10.1042/BSR20181073. PMID:30135143<ref>PMID:30135143</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5nfd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Bianchi, S]]		[[Category: Bianchi, S]]
	[[Category: Kraatz, S H.W]]		[[Category: Kraatz, S H.W]]

OCA at 07:56, 2 May 2018

OCA — Wed, 02 May 2018 07:56:43 GMT

←Older revision		Revision as of 07:56, 2 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5nfd ~~is ON HOLD until Mar 13 2019~~	+	==Antiparallel monomeric coiled coil of Kif21A==
-		+	<StructureSection load='5nfd' size='340' side='right' caption='[[5nfd]], [[Resolution\|resolution]] 2.18Å' scene=''>
-	~~Authors~~: ~~Kraatz~~, S.H.W., ~~Bianchi~~, S., ~~Steinmetz~~, M.O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5nfd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NFD FirstGlance]. <br>
-	~~Description: Antiparallel monomeric coiled coil of Kif21A~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfd OCA], [http://pdbe.org/5nfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nfd RCSB], [http://www.ebi.ac.uk/pdbsum/5nfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfd ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Kraatz, S~~.H.W]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Congenital fibrosis of extraocular muscles. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
		+	__TOC__
		+	</StructureSection>
	[[Category: Bianchi, S]]		[[Category: Bianchi, S]]
-	[[Category: Steinmetz, M.O]]	+	[[Category: Kraatz, S H.W]]
		+	[[Category: Steinmetz, M O]]
		+	[[Category: Coiled coil]]
		+	[[Category: Kinesin]]
		+	[[Category: Motor protein]]

OCA: Protected "5nfd" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 10:02:24 GMT

Protected "5nfd" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5nfd is ON HOLD until Mar 13 2019 Authors: Kraatz, S.H.W., Bianchi, S., Steinmetz, M.O. Description: Antiparallel monomeric coiled coil of Kif21A [...

OCA — Wed, 05 Apr 2017 10:02:23 GMT

New page: '''Unreleased structure''' The entry 5nfd is ON HOLD until Mar 13 2019 Authors: Kraatz, S.H.W., Bianchi, S., Steinmetz, M.O. Description: Antiparallel monomeric coiled coil of Kif21A [...

New page

'''Unreleased structure'''

The entry 5nfd is ON HOLD until Mar 13 2019

Authors: Kraatz, S.H.W., Bianchi, S., Steinmetz, M.O.

Description: Antiparallel monomeric coiled coil of Kif21A
[[Category: Unreleased Structures]]
[[Category: Kraatz, S.H.W]]
[[Category: Bianchi, S]]
[[Category: Steinmetz, M.O]]