5nj7 - Revision history

OCA at 13:01, 15 November 2023

OCA — Wed, 15 Nov 2023 13:01:22 GMT

←Older revision		Revision as of 13:01, 15 November 2023
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	<StructureSection load='5nj7' size='340' side='right'caption='[[5nj7]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='5nj7' size='340' side='right'caption='[[5nj7]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nj7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nj7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NJ7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=A6R:arsenoplatin~~-~~1'>A6R</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~1~~.27.5 3.1.27.5]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A6R:arsenoplatin-1'>A6R</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nj7 OCA], [~~http~~://pdbe.org/5nj7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nj7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nj7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nj7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nj7 OCA], [https://pdbe.org/5nj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nj7 RCSB], [https://www.ebi.ac.uk/pdbsum/5nj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nj7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>	+	[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pancreatic ribonuclease]]~~	+	[[Category: Ferraro G]]
-	[[Category: Ferraro, G]]	+	[[Category: Merlino A]]
-	[[Category: Merlino, A]]	+
-	~~[[Category: Arsenoplatin]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal based drug]]~~	+
-	~~[[Category: Ribonuclease~~]]	+

OCA at 06:29, 29 May 2019

OCA — Wed, 29 May 2019 06:29:11 GMT

←Older revision		Revision as of 06:29, 29 May 2019
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	==The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and arsenoplatin-1==		==The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and arsenoplatin-1==
-	<StructureSection load='5nj7' size='340' side='right' caption='[[5nj7]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='5nj7' size='340' side='right'caption='[[5nj7]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5nj7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5nj7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJ7 FirstGlance]. <br>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>		[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Arsenoplatins are adducts of two chemically important anticancer drugs, cisplatin and arsenic trioxide, that have a Pt(II) bond to an As(III) hydroxide center. Screens of the NCI-60 human tumor cell lines reveal that arsenoplatin-1 (AP-1), [Pt(mu-NHC(CH3)O)2ClAs(OH)2], the first representative of this novel class of anticancer agents, displays a superior activity profile relative to the parent drugs As2O3 or cisplatin in a majority of cancer cell lines tested. These activity profiles are important because the success of arsenic trioxide in blood cancers (such as APL) has not been seen in solid tumors due to the rapid clearance of arsenous acid from the body. To understand the biological chemistry of these compounds, we evaluated interactions of AP-1 with the two important classes of biomolecules-proteins and DNA. The first structural studies of AP-1 bound to model proteins reveal that platinum(II) binds the Nepsilon of His in a manner that preserves the Pt-As bond. We find that AP-1 readily enters cells and binds to DNA with an intact Pt-As bond (Pt:As ratio of 1). At longer incubation times, however, the Pt:As ratio in DNA samples increases, suggesting that the Pt-As bond breaks and releases the As(OH)2 moiety. We conclude that arsenoplatin-1 has the potential to deliver both Pt and As species to a variety of hematological and solid cancers.
		+
		+	Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.,Miodragovic D, Merlino A, Swindell EP, Bogachkov A, Ahn RW, Abuhadba S, Ferraro G, Marzo T, Mazar AP, Messori L, O'Halloran TV J Am Chem Soc. 2019 Apr 24;141(16):6453-6457. doi: 10.1021/jacs.8b13681. Epub, 2019 Apr 15. PMID:30943017<ref>PMID:30943017</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5nj7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Pancreatic ribonuclease]]		[[Category: Pancreatic ribonuclease]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]

OCA at 05:20, 16 May 2018

OCA — Wed, 16 May 2018 05:20:04 GMT

←Older revision		Revision as of 05:20, 16 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5nj7 is ON HOLD until Paper Publication~~	+	==The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and arsenoplatin-1==
-		+	<StructureSection load='5nj7' size='340' side='right' caption='[[5nj7]], [[Resolution\|resolution]] 2.15Å' scene=''>
-	~~Authors: Ferraro, G., Merlino, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5nj7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJ7 FirstGlance]. <br>
-	~~Description:~~ The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and arsenoplatin-1	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A6R:arsenoplatin-1'>A6R</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nj7 OCA], [http://pdbe.org/5nj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nj7 RCSB], [http://www.ebi.ac.uk/pdbsum/5nj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nj7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Pancreatic ribonuclease]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]
	[[Category: Merlino, A]]		[[Category: Merlino, A]]
		+	[[Category: Arsenoplatin]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metal based drug]]
		+	[[Category: Ribonuclease]]

OCA: Protected "5nj7" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 10:12:36 GMT

Protected "5nj7" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:12, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5nj7 is ON HOLD until Paper Publication Authors: Ferraro, G., Merlino, A. Description: The X-ray structure of the adduct formed in the reaction bet...

OCA — Wed, 05 Apr 2017 10:12:34 GMT

New page: '''Unreleased structure''' The entry 5nj7 is ON HOLD until Paper Publication Authors: Ferraro, G., Merlino, A. Description: The X-ray structure of the adduct formed in the reaction bet...

New page

'''Unreleased structure'''

The entry 5nj7 is ON HOLD until Paper Publication

Authors: Ferraro, G., Merlino, A.

Description: The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and arsenoplatin-1
[[Category: Unreleased Structures]]
[[Category: Ferraro, G]]
[[Category: Merlino, A]]