5nk9 - Revision history

OCA at 13:02, 15 November 2023

OCA — Wed, 15 Nov 2023 13:02:42 GMT

←Older revision		Revision as of 13:02, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='5nk9' size='340' side='right'caption='[[5nk9]], [[Resolution\|resolution]] 1.59Å' scene=''>		<StructureSection load='5nk9' size='340' side='right'caption='[[5nk9]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nk9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NK9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NK9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nk9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NK9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=912:(2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide'>912</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.588Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA2, ECK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=912:(2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide'>912</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nk9 OCA], [https://pdbe.org/5nk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nk9 RCSB], [https://www.ebi.ac.uk/pdbsum/5nk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nk9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nk9 OCA], [~~http~~://pdbe.org/5nk9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nk9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nk9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nk9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[~~http~~://omim.org/entry/613020 613020]]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref> <ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[~~http~~://omim.org/entry/116600 116600]]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref> <ref>PMID:19005574</ref> <ref>PMID:19306328</ref> <ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>	+	[https://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[https://omim.org/entry/613020 613020]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref> <ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[https://omim.org/entry/116600 116600]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref> <ref>PMID:19005574</ref> <ref>PMID:19306328</ref> <ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref> <ref>PMID:16236711</ref> <ref>PMID:18339848</ref> <ref>PMID:19573808</ref> <ref>PMID:20679435</ref> <ref>PMID:20861311</ref>	+	[https://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref> <ref>PMID:16236711</ref> <ref>PMID:18339848</ref> <ref>PMID:19573808</ref> <ref>PMID:20679435</ref> <ref>PMID:20861311</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Receptor protein-tyrosine kinase]]~~	+	[[Category: Gande SL]]
-	[[Category: Gande~~, S L~~]]	+	[[Category: Heinzlmeir S]]
-	[[Category: Heinzlmeir, S]]	+	[[Category: Kudlinzki D]]
-	[[Category: Kudlinzki, D]]	+	[[Category: Kuester B]]
-	[[Category: Kuester, B]]	+	[[Category: Linhard VL]]
-	[[Category: Linhard~~, V L~~]]	+	[[Category: Medard G]]
-	[[Category: Medard, G]]	+	[[Category: Saxena K]]
-	[[Category: Saxena, K]]	+	[[Category: Schwalbe H]]
-	[[Category: Schwalbe, H]]	+	[[Category: Witt K]]
-	[[Category: Witt, K]]	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Protein tyrosine kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 17:12, 14 August 2019

OCA — Wed, 14 Aug 2019 17:12:02 GMT

←Older revision		Revision as of 17:12, 14 August 2019
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Ephrin receptor\|Ephrin receptor]]	+	*[[Ephrin receptor 3D structures\|Ephrin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:04, 12 June 2019

OCA — Wed, 12 Jun 2019 06:04:21 GMT

←Older revision		Revision as of 06:04, 12 June 2019
Line 1:		Line 1:

	==Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2e==		==Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2e==
-	<StructureSection load='5nk9' size='340' side='right' caption='[[5nk9]], [[Resolution\|resolution]] 1.59Å' scene=''>	+	<StructureSection load='5nk9' size='340' side='right'caption='[[5nk9]], [[Resolution\|resolution]] 1.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nk9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NK9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nk9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NK9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=912:(2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide'>912</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=912:(2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide'>912</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA2, ECK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nk9 OCA], [http://pdbe.org/5nk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nk9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nk9 OCA], [http://pdbe.org/5nk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nk9 ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 5nk9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5nk9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ephrin receptor\|Ephrin receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
-	[[Category: ~~GANDE~~, S L]]	+	[[Category: Gande, S L]]
-	[[Category: ~~HEINZLMEIR~~, S]]	+	[[Category: Heinzlmeir, S]]
-	[[Category: ~~KUDLINZKI~~, D]]	+	[[Category: Kudlinzki, D]]
-	[[Category: ~~KUESTER~~, B]]	+	[[Category: Kuester, B]]
-	[[Category: ~~LINHARD~~, V L]]	+	[[Category: Linhard, V L]]
-	[[Category: ~~MEDARD~~, G]]	+	[[Category: Medard, G]]
-	[[Category: ~~SAXENA~~, K]]	+	[[Category: Saxena, K]]
-	[[Category: ~~SCHWALBE~~, H]]	+	[[Category: Schwalbe, H]]
-	[[Category: ~~WITT~~, K]]	+	[[Category: Witt, K]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Protein tyrosine kinase]]		[[Category: Protein tyrosine kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:17, 3 August 2017

OCA — Thu, 03 Aug 2017 08:17:18 GMT

←Older revision		Revision as of 08:17, 3 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~5nk9~~ is ~~ON HOLD~~	+	==Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2e==
		+	<StructureSection load='5nk9' size='340' side='right' caption='[[5nk9]], [[Resolution\|resolution]] 1.59Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5nk9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NK9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=912:(2~{Z})-~{N}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide'>912</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nk9 OCA], [http://pdbe.org/5nk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nk9 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[http://omim.org/entry/613020 613020]]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref> <ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[http://omim.org/entry/116600 116600]]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref> <ref>PMID:19005574</ref> <ref>PMID:19306328</ref> <ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref> <ref>PMID:16236711</ref> <ref>PMID:18339848</ref> <ref>PMID:19573808</ref> <ref>PMID:20679435</ref> <ref>PMID:20861311</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The receptor tyrosine kinase EPHA2 has gained attention as a therapeutic drug target for cancer and infectious diseases. However, EPHA2 research and EPHA2-based therapies have been hampered by the lack of selective small-molecule inhibitors. Herein we report the synthesis and evaluation of dedicated EPHA2 inhibitors based on the clinical BCR-ABL/SRC inhibitor dasatinib as a lead structure. We designed hybrid structures of dasatinib and the previously known EPHA2 binders CHEMBL249097, PD-173955, and a known EPHB4 inhibitor in order to exploit both the ATP pocket entrance as well as the ribose pocket as binding epitopes in the kinase EPHA2. Medicinal chemistry and inhibitor design were guided by a chemical proteomics approach, allowing early selectivity profiling of the newly synthesized inhibitor candidates. Concomitant protein crystallography of 17 inhibitor co-crystals delivered detailed insight into the atomic interactions that underlie the structure-affinity relationship. Finally, the anti-proliferative effect of the inhibitor candidates was confirmed in the glioblastoma cell line SF-268. In this work, we thus discovered a novel EPHA2 inhibitor candidate that features an improved selectivity profile while maintaining potency against EPHA2 and anticancer activity in SF-268 cells.

-	~~Authors: KUDLINZKI, D~~., ~~LINHARD~~, ~~V.L.~~, ~~WITT~~, K., ~~GANDE~~, S~~.L., SAXENA~~, K., ~~HEINZLMEIR~~, S., ~~MEDARD~~, G.~~, KUESTER, B~~., ~~SCHWALBE, H~~.	+	Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.,Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhard V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M, Schwalbe H, Kuster B, Medard G ChemMedChem. 2017 Jun 21;12(12):999-1011. doi: 10.1002/cmdc.201700217. Epub 2017 , Jun 12. PMID:28544567<ref>PMID:28544567</ref>

-	~~Description: Crystal Structure~~ of ~~Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2e~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Linhard~~, V.L]]	+	<div class="pdbe-citations 5nk9" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Kudlinzki~~, D]]	+	== References ==
-	[[Category: ~~Saxena~~, K]]	+	<references/>
-	[[Category: ~~Witt~~, K]]	+	__TOC__
-	[[Category: ~~Gande~~, S.L]]	+	</StructureSection>
-	[[Category: ~~Medard~~, G]]	+	[[Category: Receptor protein-tyrosine kinase]]
-	[[Category: ~~Schwalbe~~, H]]	+	[[Category: GANDE, S L]]
-	[[Category: ~~Heinzlmeir~~, S]]	+	[[Category: HEINZLMEIR, S]]
-	[[Category: ~~Kuester~~, B]]	+	[[Category: KUDLINZKI, D]]
		+	[[Category: KUESTER, B]]
		+	[[Category: LINHARD, V L]]
		+	[[Category: MEDARD, G]]
		+	[[Category: SAXENA, K]]
		+	[[Category: SCHWALBE, H]]
		+	[[Category: WITT, K]]
		+	[[Category: Complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Protein tyrosine kinase]]
		+	[[Category: Transferase]]

OCA: Protected "5nk9" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 10:15:16 GMT

Protected "5nk9" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:15, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5nk9 is ON HOLD Authors: KUDLINZKI, D., LINHARD, V.L., WITT, K., GANDE, S.L., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H. Des...

OCA — Wed, 05 Apr 2017 10:15:15 GMT

New page: '''Unreleased structure''' The entry 5nk9 is ON HOLD Authors: KUDLINZKI, D., LINHARD, V.L., WITT, K., GANDE, S.L., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H. Des...

New page

'''Unreleased structure'''

The entry 5nk9 is ON HOLD

Authors: KUDLINZKI, D., LINHARD, V.L., WITT, K., GANDE, S.L., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.

Description: Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2e
[[Category: Unreleased Structures]]
[[Category: Linhard, V.L]]
[[Category: Kudlinzki, D]]
[[Category: Saxena, K]]
[[Category: Witt, K]]
[[Category: Gande, S.L]]
[[Category: Medard, G]]
[[Category: Schwalbe, H]]
[[Category: Heinzlmeir, S]]
[[Category: Kuester, B]]