5nn9 - Revision history

OCA at 12:08, 26 August 2020

OCA — Wed, 26 Aug 2020 12:08:38 GMT

←Older revision		Revision as of 12:08, 26 August 2020
Line 1:		Line 1:
		+
	==REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS==		==REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS==
-	<StructureSection load='5nn9' size='340' side='right' caption='[[5nn9]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5nn9' size='340' side='right'caption='[[5nn9]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nn9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a5 I75a5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NN9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nn9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a5 I75a5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NN9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://pdbe.org/5nn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://pdbe.org/5nn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nn9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/5nn9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/5nn9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 38:
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: I75a5]]		[[Category: I75a5]]
		+	[[Category: Large Structures]]
	[[Category: Baker, A T]]		[[Category: Baker, A T]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]

OCA at 03:17, 7 February 2016

OCA — Sun, 07 Feb 2016 03:17:28 GMT

←Older revision		Revision as of 03:17, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='5nn9' size='340' side='right' caption='[[5nn9]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5nn9' size='340' side='right' caption='[[5nn9]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nn9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NN9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nn9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a5 I75a5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NN9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://pdbe.org/5nn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~NRAM_IATRA NRAM_IATRA~~]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.	+	[[http://www.uniprot.org/uniprot/NRAM_I75A5 NRAM_I75A5]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5nn9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5nn9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: ~~Influenza a virus~~]]	+	[[Category: I75a5]]
	[[Category: Baker, A T]]		[[Category: Baker, A T]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]

OCA at 07:25, 24 December 2014

OCA — Wed, 24 Dec 2014 07:25:23 GMT

←Older revision		Revision as of 07:25, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NRAM_IATRA NRAM_IATRA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:55, 10 December 2014

OCA — Wed, 10 Dec 2014 16:55:41 GMT

←Older revision		Revision as of 16:55, 10 December 2014
Line 1:		Line 1:
-	[[~~Image~~:5nn9.~~png\|left~~\|200px]]	+	==REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS==
		+	<StructureSection load='5nn9' size='340' side='right' caption='[[5nn9]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5nn9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NN9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/5nn9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the N9 subtype neuraminidase of influenza virus was refined by simulated annealing and conventional techniques to an R-factor of 0.172 for data in the resolution range 6.0 to 2.2 A. The r.m.s. deviation from ideal values of bond lengths is 0.014 A. The structure is similar to that of N2 subtype neuraminidase both in secondary structure elements and in their connections. The three-dimensional structures of several escape mutants of neuraminidase, selected with antineuraminidase monoclonal antibodies, are also reported. In every case, structural changes associated with the point mutation are confined to the mutation site or to residues that are spatially immediately adjacent to it. The failure of antisera to cross-react between N2 and N9 subtypes may be correlated with the absence of conserved, contiguous surface structures of area 700 A2 or more.

-	~~{{STRUCTURE_5nn9\| PDB=5nn9 \| SCENE= }}~~	+	Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.,Tulip WR, Varghese JN, Baker AT, van Donkelaar A, Laver WG, Webster RG, Colman PM J Mol Biol. 1991 Sep 20;221(2):487-97. PMID:1920429<ref>PMID:1920429</ref>

-	~~===REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_1920429}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[5nn9]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Influenza_a_virus Influenza~~ a ~~virus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=5NN9 OCA].~~	+

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:001920429<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Baker, A T.]]	+	[[Category: Baker, A T]]
-	[[Category: Colman, P M.]]	+	[[Category: Colman, P M]]
-	[[Category: Laver, W G.]]	+	[[Category: Laver, W G]]
-	[[Category: Tulip, W R.]]	+	[[Category: Tulip, W R]]
-	[[Category: Vandonkelaar, A.]]	+	[[Category: Vandonkelaar, A]]
-	[[Category: Varghese, J N.]]	+	[[Category: Varghese, J N]]
-	[[Category: Webster, R G.]]	+	[[Category: Webster, R G]]

OCA at 05:26, 20 October 2012

OCA — Sat, 20 Oct 2012 05:26:40 GMT

←Older revision		Revision as of 05:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[5nn9]] is a 1 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA].	+	[[5nn9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA].

	==See Also==		==See Also==

OCA: Protected "5nn9" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 10:02:50 GMT

Protected "5nn9" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 25 July 2012

OCA at 10:02, 25 July 2012

OCA — Wed, 25 Jul 2012 10:02:48 GMT

←Older revision		Revision as of 10:02, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:5nn9.png\|left\|200px]]		[[Image:5nn9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_5nn9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_5nn9\| PDB=5nn9 \| SCENE= }}		{{STRUCTURE_5nn9\| PDB=5nn9 \| SCENE= }}

	===REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS===		===REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_1920429}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 1920429 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_1920429}}		{{ABSTRACT_PUBMED_1920429}}

	==About this Structure==		==About this Structure==
-	~~5NN9~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Unidentified_influenza_virus Unidentified influenza~~ virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA].	+	[[5nn9]] is a 1 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA].
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~1920429~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:001920429</ref><references group="xtra"/>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: ~~Unidentified influenza~~ virus]]	+	[[Category: Influenza a virus]]
	[[Category: Baker, A T.]]		[[Category: Baker, A T.]]
	[[Category: Colman, P M.]]		[[Category: Colman, P M.]]
Line 33:		Line 24:
	[[Category: Varghese, J N.]]		[[Category: Varghese, J N.]]
	[[Category: Webster, R G.]]		[[Category: Webster, R G.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:43:04 2009''

OCA at 08:43, 16 February 2009

OCA — Mon, 16 Feb 2009 08:43:06 GMT

←Older revision		Revision as of 08:43, 16 February 2009
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	==About this Structure==		==About this Structure==
-	5NN9 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA].	+	5NN9 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NN9 OCA].

	==Reference==		==Reference==
-	Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants., Tulip WR, Varghese JN, Baker AT, van Donkelaar A, Laver WG, Webster RG, Colman PM, J Mol Biol. 1991 Sep 20;221(2):487-97. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/1920429 1920429]~~	+	<ref group="xtra">PMID:1920429</ref><references group="xtra"/>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: Single protein]]
	[[Category: Unidentified influenza virus]]		[[Category: Unidentified influenza virus]]
	[[Category: Baker, A T.]]		[[Category: Baker, A T.]]
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	[[Category: Webster, R G.]]		[[Category: Webster, R G.]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 14~~:07:~~16 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:43:04 2009''

OCA at 11:07, 3 July 2008

OCA — Thu, 03 Jul 2008 11:07:17 GMT

←Older revision		Revision as of 11:07, 3 July 2008
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-	[[Image:5nn9.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:5nn9.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_5nn9\| PDB=5nn9 \| SCENE= }}		{{STRUCTURE_5nn9\| PDB=5nn9 \| SCENE= }}

-	~~'''~~REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS~~'''~~	+	===REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS===


-	~~==Overview==~~	+	<!--
-	The ~~crystal structure of~~ the ~~N9 subtype neuraminidase of influenza virus was refined by simulated annealing and conventional techniques~~ to ~~an R-factor of 0.172 for data in~~ the ~~resolution range 6~~.~~0 to 2~~.~~2 A. The r.m.s. deviation from ideal values of bond lengths~~ is 0.014 A. The structure is similar to that of N2 subtype neuraminidase both in secondary structure elements and in their connections. The three-dimensional structures of several escape mutants of neuraminidase, selected with antineuraminidase monoclonal antibodies, are also reported. In every case, structural changes associated with the ~~point mutation are confined to the mutation site or to residues that are spatially immediately adjacent to it~~. ~~The failure of antisera to cross~~-~~react between N2 and N9 subtypes may be correlated with the absence of conserved, contiguous surface structures of area 700 A2 or more.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_1920429}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 1920429 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_1920429}}

	==About this Structure==		==About this Structure==
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	[[Category: Varghese, J N.]]		[[Category: Varghese, J N.]]
	[[Category: Webster, R G.]]		[[Category: Webster, R G.]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:36:19 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:07:16 2008''

OCA at 19:36, 4 May 2008

OCA — Sun, 04 May 2008 19:36:20 GMT

←Older revision		Revision as of 19:36, 4 May 2008
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	[[Image:5nn9.gif\|left\|200px]]		[[Image:5nn9.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 5nn9 \|SIZE=350\|CAPTION= <scene name='initialview01'>5nn9</scene>~~, ~~resolution 2~~.~~3Å~~	+	The line below this paragraph, containing "STRUCTURE_5nn9", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <~~scene ~~name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY= <span class='plainlinks'>[http://en~~.~~wikipedia.org/wiki/Exo~~-~~alpha~~-~~sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span~~>	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	\|~~DOMAIN~~=	+	{{STRUCTURE_5nn9\| PDB=5nn9 \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nn9 OCA], [http://www.ebi.ac.uk/pdbsum/5nn9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5nn9 RCSB]</span>	+
-	}}	+

	'''REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS'''		'''REFINED ATOMIC STRUCTURES OF N9 SUBTYPE INFLUENZA VIRUS NEURAMINIDASE AND ESCAPE MUTANTS'''
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	[[Category: Varghese, J N.]]		[[Category: Varghese, J N.]]
	[[Category: Webster, R G.]]		[[Category: Webster, R G.]]
-	~~[[Category: hydrolase(o-glycosyl)]]~~	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:36:19 2008''
-		+
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:41:53 2008''	+