5nnx - Revision history

OCA at 13:13, 15 November 2023

OCA — Wed, 15 Nov 2023 13:13:39 GMT

←Older revision		Revision as of 13:13, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='5nnx' size='340' side='right'caption='[[5nnx]], [[Resolution\|resolution]] 3.29Å' scene=''>		<StructureSection load='5nnx' size='340' side='right'caption='[[5nnx]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nnx]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NNX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nnx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NNX FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TEAD1~~, ~~TCF13, TEF1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.29Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnx OCA], [~~http~~://pdbe.org/5nnx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nnx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nnx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnx OCA], [https://pdbe.org/5nnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nnx RCSB], [https://www.ebi.ac.uk/pdbsum/5nnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:[~~http~~://omim.org/entry/108985 108985]]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:18579750</ref> <ref>PMID:20123905</ref> <ref>PMID:15016762</ref>	+	[https://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:[https://omim.org/entry/108985 108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:18579750</ref> <ref>PMID:20123905</ref> <ref>PMID:15016762</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>	+	[https://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jolma, A]]	+	[[Category: Jolma A]]
-	[[Category: Morgunova, E]]	+	[[Category: Morgunova E]]
-	[[Category: Popov, A]]	+	[[Category: Popov A]]
-	[[Category: Taipale, J]]	+	[[Category: Taipale J]]
-	[[Category: Yin, Y]]	+	[[Category: Yin Y]]
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 13:13, 10 May 2019

OCA — Fri, 10 May 2019 13:13:59 GMT

←Older revision		Revision as of 13:13, 10 May 2019
Line 1:		Line 1:

	==TEAD1 bound to DNA==		==TEAD1 bound to DNA==
-	<StructureSection load='5nnx' size='340' side='right' caption='[[5nnx]], [[Resolution\|resolution]] 3.29Å' scene=''>	+	<StructureSection load='5nnx' size='340' side='right'caption='[[5nnx]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nnx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nnx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnx OCA], [http://pdbe.org/5nnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnx RCSB], [http://www.ebi.ac.uk/pdbsum/5nnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnx ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1, TCF13, TEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnx OCA], [http://pdbe.org/5nnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnx RCSB], [http://www.ebi.ac.uk/pdbsum/5nnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jolma, A]]		[[Category: Jolma, A]]
	[[Category: Morgunova, E]]		[[Category: Morgunova, E]]

OCA at 14:00, 27 April 2017

OCA — Thu, 27 Apr 2017 14:00:41 GMT

←Older revision		Revision as of 14:00, 27 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5nnx ~~is ON HOLD until Paper Publication~~	+	==TEAD1 bound to DNA==
-		+	<StructureSection load='5nnx' size='340' side='right' caption='[[5nnx]], [[Resolution\|resolution]] 3.29Å' scene=''>
-	~~Authors~~: ~~Morgunova~~, E., ~~Jolma~~, A., ~~Yin~~, Y., ~~Popov~~, A., ~~Taipale~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5nnx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNX FirstGlance]. <br>
-	~~Description~~: ~~TEAD1 bound to DNA~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnx OCA], [http://pdbe.org/5nnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnx RCSB], [http://www.ebi.ac.uk/pdbsum/5nnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:[http://omim.org/entry/108985 108985]]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:18579750</ref> <ref>PMID:20123905</ref> <ref>PMID:15016762</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jolma, A]]
		+	[[Category: Morgunova, E]]
	[[Category: Popov, A]]		[[Category: Popov, A]]
		+	[[Category: Taipale, J]]
	[[Category: Yin, Y]]		[[Category: Yin, Y]]
-	[[Category: ~~Jolma, A~~]]	+	[[Category: Dna binding]]
-	[[Category: ~~Taipale, J~~]]	+	[[Category: Transcription]]
-	[[Category: ~~Morgunova, E~~]]	+	[[Category: Transcription factor]]

OCA: Protected "5nnx" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2017 09:42:28 GMT

Protected "5nnx" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:42, 19 April 2017

OCA: New page: '''Unreleased structure''' The entry 5nnx is ON HOLD until Paper Publication Authors: Morgunova, E., Jolma, A., Yin, Y., Popov, A., Taipale, J. Description: TEAD1 bound to DNA [[Catego...

OCA — Wed, 19 Apr 2017 09:42:27 GMT

New page: '''Unreleased structure''' The entry 5nnx is ON HOLD until Paper Publication Authors: Morgunova, E., Jolma, A., Yin, Y., Popov, A., Taipale, J. Description: TEAD1 bound to DNA [[Catego...

New page

'''Unreleased structure'''

The entry 5nnx is ON HOLD until Paper Publication

Authors: Morgunova, E., Jolma, A., Yin, Y., Popov, A., Taipale, J.

Description: TEAD1 bound to DNA
[[Category: Unreleased Structures]]
[[Category: Popov, A]]
[[Category: Yin, Y]]
[[Category: Jolma, A]]
[[Category: Taipale, J]]
[[Category: Morgunova, E]]