5noh - Revision history

OCA at 13:15, 15 November 2023

OCA — Wed, 15 Nov 2023 13:15:46 GMT

←Older revision		Revision as of 13:15, 15 November 2023
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	<StructureSection load='5noh' size='340' side='right'caption='[[5noh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5noh' size='340' side='right'caption='[[5noh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5noh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hrsv Hrsv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5noh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NOH FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">M2, ~~DZ88_50545gpM2 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=11250 HRSV])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5noh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5noh OCA], [~~http~~://pdbe.org/5noh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5noh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5noh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5noh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5noh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5noh OCA], [https://pdbe.org/5noh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5noh RCSB], [https://www.ebi.ac.uk/pdbsum/5noh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5noh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M21_HRSVA M21_HRSVA] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.<ref>PMID:8552680</ref> <ref>PMID:9420254</ref> <ref>PMID:10364337</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hrsv~~]]	+	[[Category: Human orthopneumovirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hernandez, Y ~~Almeida~~]]	+	[[Category: Almeida Hernandez Y]]
-	[[Category: Josts, I]]	+	[[Category: Josts I]]
-	[[Category: Molina~~, I G]]~~	+	[[Category: Molina IG]]
-	~~[[Category: Prat-Gay, G de~~]]	+	[[Category: Tidow H]]
-	[[Category: Tidow, H]]	+	[[Category: De Prat-Gay G]]
-	[[Category: ~~Protein]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 06:46, 16 October 2019

OCA — Wed, 16 Oct 2019 06:46:06 GMT

←Older revision		Revision as of 06:46, 16 October 2019
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	==HRSV M2-1 core domain==		==HRSV M2-1 core domain==
-	<StructureSection load='5noh' size='340' side='right' caption='[[5noh]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5noh' size='340' side='right'caption='[[5noh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5noh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NOH FirstGlance]. <br>		<table><tr><td colspan='2'>[[5noh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NOH FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5noh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5noh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Hrsv]]		[[Category: Hrsv]]
		+	[[Category: Large Structures]]
	[[Category: Hernandez, Y Almeida]]		[[Category: Hernandez, Y Almeida]]
	[[Category: Josts, I]]		[[Category: Josts, I]]

OCA at 06:27, 18 April 2018

OCA — Wed, 18 Apr 2018 06:27:00 GMT

←Older revision		Revision as of 06:27, 18 April 2018
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	<StructureSection load='5noh' size='340' side='right' caption='[[5noh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5noh' size='340' side='right' caption='[[5noh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5noh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5noh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NOH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5noh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5noh OCA], [http://pdbe.org/5noh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5noh RCSB], [http://www.ebi.ac.uk/pdbsum/5noh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5noh ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">M2, DZ88_50545gpM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11250 HRSV])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5noh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5noh OCA], [http://pdbe.org/5noh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5noh RCSB], [http://www.ebi.ac.uk/pdbsum/5noh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5noh ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human syncytial respiratory virus is a nonsegmented negative-strand RNA virus with serious implications for respiratory disease in infants, and has recently been reclassified into a new family, Pneumoviridae. One of the main reasons for this classification is the unique presence of a transcriptional antiterminator, called M2-1. The puzzling mechanism of action of M2-1, which is a rarity among antiterminators in viruses and is part of the RNA polymerase complex, relies on dissecting the structure and function of this multidomain tetramer. The RNA-binding activity is located in a monomeric globular `core' domain, a high-resolution crystal structure of which is now presented. The structure reveals a compact domain which is superimposable on the full-length M2-1 tetramer, with additional electron density for the C-terminal tail that was not observed in the previous models. Moreover, its folding stability was determined through chemical denaturation, which shows that the secondary and tertiary structure unfold concomitantly, which is indicative of a two-state equilibrium. These results constitute a further step in the understanding of this unique RNA-binding domain, for which there is no sequence or structural counterpart outside this virus family, in addition to its implications in transcription regulation and its likeliness as an antiviral target.
		+
		+	Structure and stability of the Human respiratory syncytial virus M2-1 RNA-binding core domain reveals a compact and cooperative folding unit.,Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):23-30. doi:, 10.1107/S2053230X17017381. Epub 2017 Dec 15. PMID:29372904<ref>PMID:29372904</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5noh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hrsv]]
	[[Category: Hernandez, Y Almeida]]		[[Category: Hernandez, Y Almeida]]
	[[Category: Josts, I]]		[[Category: Josts, I]]

OCA at 05:45, 3 January 2018

OCA — Wed, 03 Jan 2018 05:45:03 GMT

←Older revision		Revision as of 05:45, 3 January 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5noh ~~is ON HOLD~~	+	==HRSV M2-1 core domain==
-		+	<StructureSection load='5noh' size='340' side='right' caption='[[5noh]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Josts, I~~.~~, Hernandez, Y~~.A.~~, Molina, I~~.G.~~, de Prat~~-~~Gay, G~~.~~, Tidow, H~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5noh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NOH FirstGlance]. <br>
-	~~Description~~: ~~HRSV M2~~-~~1 core domain~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5noh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5noh OCA], [http://pdbe.org/5noh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5noh RCSB], [http://www.ebi.ac.uk/pdbsum/5noh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5noh ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~De Prat~~-~~Gay, G]~~]	+	__TOC__
-	[[Category: ~~Molina~~, ~~I.G~~]]	+	</StructureSection>
		+	[[Category: Hernandez, Y Almeida]]
	[[Category: Josts, I]]		[[Category: Josts, I]]
-	[[Category: ~~Hernandez~~, ~~Y.A~~]]	+	[[Category: Molina, I G]]
		+	[[Category: Prat-Gay, G de]]
	[[Category: Tidow, H]]		[[Category: Tidow, H]]
		+	[[Category: Protein]]
		+	[[Category: Transcription]]

OCA: Protected "5noh" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2017 09:44:05 GMT

Protected "5noh" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:44, 19 April 2017

OCA: New page: '''Unreleased structure''' The entry 5noh is ON HOLD Authors: Josts, I., Hernandez, Y.A., Molina, I.G., de Prat-Gay, G., Tidow, H. Description: HRSV M2-1 core domain [[Category: Unrele...

OCA — Wed, 19 Apr 2017 09:44:04 GMT

New page: '''Unreleased structure''' The entry 5noh is ON HOLD Authors: Josts, I., Hernandez, Y.A., Molina, I.G., de Prat-Gay, G., Tidow, H. Description: HRSV M2-1 core domain [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 5noh is ON HOLD

Authors: Josts, I., Hernandez, Y.A., Molina, I.G., de Prat-Gay, G., Tidow, H.

Description: HRSV M2-1 core domain
[[Category: Unreleased Structures]]
[[Category: De Prat-Gay, G]]
[[Category: Molina, I.G]]
[[Category: Josts, I]]
[[Category: Hernandez, Y.A]]
[[Category: Tidow, H]]