5nq2 - Revision history

OCA at 13:21, 15 November 2023

OCA — Wed, 15 Nov 2023 13:21:31 GMT

←Older revision		Revision as of 13:21, 15 November 2023
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	<StructureSection load='5nq2' size='340' side='right'caption='[[5nq2]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='5nq2' size='340' side='right'caption='[[5nq2]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nq2]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NQ2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5NQ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nq2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] and [https://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NQ2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.54Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5nq0\|5nq0]], [[5nq3\|5nq3]], [[5npz\|5npz]], [[5nq1\|5nq1]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">SLA-2 ([http~~:~~//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])~~, ~~B2M ([http:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nq2 OCA], [https://pdbe.org/5nq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nq2 RCSB], [https://www.ebi.ac.uk/pdbsum/5nq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nq2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5nq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nq2 OCA], [~~http~~://pdbe.org/5nq2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nq2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nq2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nq2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/B1A9P6_PIG B1A9P6_PIG]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881] [[http://www.uniprot.org/uniprot/B2MG_PIG B2MG_PIG]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	+	[https://www.uniprot.org/uniprot/B1A9P6_PIG B1A9P6_PIG] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pig~~]]	+	[[Category: Sus scrofa]]
-	[[Category: ~~Rizkallah, P J~~]]	+	[[Category: Unidentified influenza virus]]
-	[[Category: ~~Sewell, A K~~]]	+	[[Category: Rizkallah PJ]]
-	[[Category: ~~Tungatt, K~~]]	+	[[Category: Sewell AK]]
-	[[Category: ~~Cd8+]]~~	+	[[Category: Tungatt K]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Influenza]]~~	+
-	~~[[Category: Mhc]]~~	+
-	~~[[Category: Porcine leukocyte antigen]]~~	+
-	~~[[Category: Swine~~]]	+

OCA at 12:09, 26 August 2020

OCA — Wed, 26 Aug 2020 12:09:59 GMT

←Older revision		Revision as of 12:09, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 5nq2 is ~~ON HOLD until Paper~~ Publication	+	=='Porcine (Sus scrofa) Major Histocompatibility Complex, class I, presenting IAYERMCNI==
		+	<StructureSection load='5nq2' size='340' side='right'caption='[[5nq2]], [[Resolution\|resolution]] 1.54Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5nq2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NQ2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5nq0\|5nq0]], [[5nq3\|5nq3]], [[5npz\|5npz]], [[5nq1\|5nq1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nq2 OCA], [http://pdbe.org/5nq2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nq2 RCSB], [http://www.ebi.ac.uk/pdbsum/5nq2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nq2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B1A9P6_PIG B1A9P6_PIG]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881] [[http://www.uniprot.org/uniprot/B2MG_PIG B2MG_PIG]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current animal models used to study respiratory pathogens suffer from anatomical disparity with humans. The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume. It may also be an important vector in the birds to human infection cycle. A major drawback of the current pig model is the inability to analyze antigen-specific CD8+ T-cell responses, which are critical to respiratory immunity. Here we address this knowledge gap using an established in-bred pig model with a high degree of genetic identity between individuals, including the MHC (Swine Leukocyte Antigen (SLA)) locus. We developed a toolset that included long-term in vitro pig T-cell culture and cloning and identification of novel immunodominant influenza-derived T-cell epitopes. We also generated structures of the two SLA class I molecules found in these animals presenting the immunodominant epitopes. These structures allowed definition of the primary anchor points for epitopes in the SLA binding groove and established SLA binding motifs that were used to successfully predict other influenza-derived peptide sequences capable of stimulating T-cells. Peptide-SLA tetramers were constructed and used to track influenza-specific T-cells ex vivo in blood, the lungs and draining lymph nodes. Aerosol immunization with attenuated single cycle influenza viruses (S-FLU) induced large numbers of CD8+ T-cells specific for conserved NP peptides in the respiratory tract. Collectively, these data substantially increase the utility of pigs as an effective model for studying protective local cellular immunity against respiratory pathogens.

-	~~Authors~~:	+	Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.,Tungatt K, Dolton G, Morgan SB, Attaf M, Fuller A, Whalley T, Hemmink JD, Porter E, Szomolay B, Montoya M, Hammond JA, Miles JJ, Cole DK, Townsend A, Bailey M, Rizkallah PJ, Charleston B, Tchilian E, Sewell AK PLoS Pathog. 2018 May 17;14(5):e1007017. doi: 10.1371/journal.ppat.1007017., eCollection 2018 May. PMID:29772011<ref>PMID:29772011</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 5nq2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pig]]
		+	[[Category: Rizkallah, P J]]
		+	[[Category: Sewell, A K]]
		+	[[Category: Tungatt, K]]
		+	[[Category: Cd8+]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza]]
		+	[[Category: Mhc]]
		+	[[Category: Porcine leukocyte antigen]]
		+	[[Category: Swine]]

OCA at 03:59, 18 April 2018

OCA — Wed, 18 Apr 2018 03:59:13 GMT

←Older revision		Revision as of 03:59, 18 April 2018
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	The entry 5nq2 is ON HOLD until Paper Publication		The entry 5nq2 is ON HOLD until Paper Publication

-	Authors: ~~Rizkallah, P.J., Tungatt, K., Sewell, A.K.~~	+	Authors:

-	Description: ~~Swine Leukocyte Antigen~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sewell, A.K]]
-	[[Category: Rizkallah, P.J]]
-	[[Category: Tungatt, K]]

OCA at 09:34, 4 May 2017

OCA — Thu, 04 May 2017 09:34:29 GMT

←Older revision		Revision as of 09:34, 4 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5nq2 is ON HOLD	+	The entry 5nq2 is ON HOLD until Paper Publication

	Authors: Rizkallah, P.J., Tungatt, K., Sewell, A.K.		Authors: Rizkallah, P.J., Tungatt, K., Sewell, A.K.

-	Description: ~~human T-cell Receptor~~	+	Description: Swine Leukocyte Antigen
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Sewell, A.K]]		[[Category: Sewell, A.K]]
	[[Category: Rizkallah, P.J]]		[[Category: Rizkallah, P.J]]
	[[Category: Tungatt, K]]		[[Category: Tungatt, K]]

OCA: Protected "5nq2" [edit=sysop:move=sysop]

OCA — Thu, 27 Apr 2017 10:46:37 GMT

Protected "5nq2" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:46, 27 April 2017

OCA: New page: '''Unreleased structure''' The entry 5nq2 is ON HOLD Authors: Rizkallah, P.J., Tungatt, K., Sewell, A.K. Description: human T-cell Receptor Category: Unreleased Structures [[Catego...

OCA — Thu, 27 Apr 2017 10:46:36 GMT

New page: '''Unreleased structure''' The entry 5nq2 is ON HOLD Authors: Rizkallah, P.J., Tungatt, K., Sewell, A.K. Description: human T-cell Receptor Category: Unreleased Structures [[Catego...

New page

'''Unreleased structure'''

The entry 5nq2 is ON HOLD

Authors: Rizkallah, P.J., Tungatt, K., Sewell, A.K.

Description: human T-cell Receptor
[[Category: Unreleased Structures]]
[[Category: Sewell, A.K]]
[[Category: Rizkallah, P.J]]
[[Category: Tungatt, K]]