5nr5 - Revision history

OCA at 12:03, 22 November 2023

OCA — Wed, 22 Nov 2023 12:03:33 GMT

←Older revision		Revision as of 12:03, 22 November 2023
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	==NMR structure and 1H, 13C and 15N signal assignments for Dictyostelium discoideum MATA protein==		==NMR structure and 1H, 13C and 15N signal assignments for Dictyostelium discoideum MATA protein==
-	<StructureSection load='5nr5' size='340' side='right'caption='[[5nr5~~]], [[NMR_Ensembles_of_Models \| 30 NMR models~~]]' scene=''>	+	<StructureSection load='5nr5' size='340' side='right'caption='[[5nr5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nr5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Dicdi Dicdi~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NR5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NR5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NR5 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>matA, DDB0188291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~44689 DICDI])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nr5 OCA], [~~http~~://pdbe.org/5nr5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nr5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nr5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nr5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nr5 OCA], [https://pdbe.org/5nr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nr5 RCSB], [https://www.ebi.ac.uk/pdbsum/5nr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nr5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q54HW9_DICDI Q54HW9_DICDI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dicdi~~]]	+	[[Category: Dictyostelium discoideum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hedgethorne, K]]	+	[[Category: Hedgethorne K]]
-	[[Category: Neuhaus, D]]	+	[[Category: Neuhaus D]]
-	[[Category: Yang, J C]]	+	[[Category: Yang J-C]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Homeobox]]~~	+
-	~~[[Category: Mating type determination factor~~]]	+

OCA at 13:15, 10 May 2019

OCA — Fri, 10 May 2019 13:15:00 GMT

←Older revision		Revision as of 13:15, 10 May 2019
Line 1:		Line 1:

	==NMR structure and 1H, 13C and 15N signal assignments for Dictyostelium discoideum MATA protein==		==NMR structure and 1H, 13C and 15N signal assignments for Dictyostelium discoideum MATA protein==
-	<StructureSection load='5nr5' size='340' side='right' caption='[[5nr5]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>	+	<StructureSection load='5nr5' size='340' side='right'caption='[[5nr5]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nr5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NR5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nr5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicdi Dicdi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NR5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nr5 OCA], [http://pdbe.org/5nr5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nr5 RCSB], [http://www.ebi.ac.uk/pdbsum/5nr5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nr5 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">matA, DDB0188291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nr5 OCA], [http://pdbe.org/5nr5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nr5 RCSB], [http://www.ebi.ac.uk/pdbsum/5nr5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nr5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dicdi]]
		+	[[Category: Large Structures]]
	[[Category: Hedgethorne, K]]		[[Category: Hedgethorne, K]]
	[[Category: Neuhaus, D]]		[[Category: Neuhaus, D]]

OCA at 04:34, 21 September 2017

OCA — Thu, 21 Sep 2017 04:34:15 GMT

←Older revision		Revision as of 04:34, 21 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5nr5 is ~~ON HOLD until Paper~~ Publication	+	==NMR structure and 1H, 13C and 15N signal assignments for Dictyostelium discoideum MATA protein==
		+	<StructureSection load='5nr5' size='340' side='right' caption='[[5nr5]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5nr5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NR5 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nr5 OCA], [http://pdbe.org/5nr5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nr5 RCSB], [http://www.ebi.ac.uk/pdbsum/5nr5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nr5 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Homeodomain proteins control the developmental transition between the haploid and diploid phases in several eukaryotic lineages, but it is not known whether this regulatory mechanism reflects the ancestral condition or, instead, convergent evolution. We have characterized the mating-type locus of the amoebozoan Dictyostelium discoideum, which encodes two pairs of small proteins that determine the three mating types of this species; none of these proteins display recognizable homology to known families. We report that the nuclear magnetic resonance structures of two of them, MatA and MatB, contain helix-turn-helix folds flanked by largely disordered amino- and carboxyl-terminal tails. This fold closely resembles that of homeodomain transcription factors, and, like those proteins, MatA and MatB each bind DNA characteristically using the third helix of their folded domains. By constructing chimeric versions containing parts of MatA and MatB, we demonstrate that the carboxyl-terminal tail, not the central DNA binding motif, confers mating specificity, providing mechanistic insight into how a third mating type might have originated. Finally, we show that these homeodomain-like proteins specify zygote function: Hemizygous diploids, formed in crosses between a wild-type strain and a mat null mutant, grow and differentiate identically to haploids. We propose that Dictyostelium MatA and MatB are divergent homeodomain proteins with a conserved function in triggering the haploid-to-diploid transition that can be traced back to the last common ancestor of eukaryotes.

-	~~Authors~~:	+	Homeodomain-like DNA binding proteins control the haploid-to-diploid transition in Dictyostelium.,Hedgethorne K, Eustermann S, Yang JC, Ogden TEH, Neuhaus D, Bloomfield G Sci Adv. 2017 Sep 1;3(9):e1602937. doi: 10.1126/sciadv.1602937. eCollection 2017 , Sep. PMID:28879231<ref>PMID:28879231</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5nr5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hedgethorne, K]]
		+	[[Category: Neuhaus, D]]
		+	[[Category: Yang, J C]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Homeobox]]
		+	[[Category: Mating type determination factor]]

OCA: Protected "5nr5" [edit=sysop:move=sysop]

OCA — Thu, 04 May 2017 09:36:27 GMT

Protected "5nr5" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:36, 4 May 2017

OCA: New page: '''Unreleased structure''' The entry 5nr5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Thu, 04 May 2017 09:36:26 GMT

New page: '''Unreleased structure''' The entry 5nr5 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5nr5 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]