5nur - Revision history

OCA at 11:50, 1 February 2024

OCA — Thu, 01 Feb 2024 11:50:46 GMT

←Older revision		Revision as of 11:50, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NUR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NUR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GP1:GLUCOSAMINE+1-PHOSPHATE'>GP1</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.29Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GP1:GLUCOSAMINE+1-PHOSPHATE'>GP1</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [https://pdbe.org/5nur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [https://www.ebi.ac.uk/pdbsum/5nur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [https://pdbe.org/5nur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [https://www.ebi.ac.uk/pdbsum/5nur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:25, 7 December 2022

OCA — Wed, 07 Dec 2022 08:25:27 GMT

←Older revision		Revision as of 08:25, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='5nur' size='340' side='right'caption='[[5nur]], [[Resolution\|resolution]] 3.29Å' scene=''>		<StructureSection load='5nur' size='340' side='right'caption='[[5nur]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886~~] and [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5NUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NUR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4~~</scene>, <scene name='pdbligand=GP1:GLUCOSAMINE+1-PHOSPHATE'>GP1</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GP1:GLUCOSAMINE+1-PHOSPHATE'>GP1</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ompF, cmlB, coa, cry, tolF, b0929, JW0912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), mlaA, vacJ, AGG09_21815, BB749_07690, BCB67_11070, BL143_09030, BN49_3944, PMK1_00224, SAMEA3531778_01593, SM30_03044, SM57_02930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [https://pdbe.org/5nur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [https://www.ebi.ac.uk/pdbsum/5nur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [~~http~~://pdbe.org/5nur PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nur PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI]] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>	+	[https://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
		+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abellon-Ruiz, J]]	+	[[Category: Abellon-Ruiz J]]
-	[[Category: Basle, A]]	+	[[Category: Basle A]]
-	~~[[Category: Berg, B van den~~]]	+	[[Category: Bumann D]]
-	[[Category: Bumann, D]]	+	[[Category: Claudi B]]
-	[[Category: Claudi, B]]	+	[[Category: Kaptan SS]]
-	[[Category: Kaptan~~, S S~~]]	+	[[Category: Kleinekathofer U]]
-	[[Category: Kleinekathofer, U]]	+	[[Category: Van den Berg B]]
-	[[Category: ~~Lipid asymmetry]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Outer membrane]]~~	+
-	~~[[Category: Phospholipid translocation~~]]	+

OCA at 11:17, 29 July 2020

OCA — Wed, 29 Jul 2020 11:17:41 GMT

←Older revision		Revision as of 11:17, 29 July 2020
Line 1:		Line 1:

	==Structural basis for maintenance of bacterial outer membrane lipid asymmetry==		==Structural basis for maintenance of bacterial outer membrane lipid asymmetry==
-	<StructureSection load='5nur' size='340' side='right' caption='[[5nur]], [[Resolution\|resolution]] 3.29Å' scene=''>	+	<StructureSection load='5nur' size='340' side='right'caption='[[5nur]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NUR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~KDO~~:~~3-DEOXY-D-MANNO-OCT-2-ULOSONIC~~+~~ACID~~'>~~KDO~~</scene>, <scene name='pdbligand=~~L1L~~:~~[(2R,3R,4R,5S,6R)~~-~~3-AZANYL-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]+DIHYDROGEN+~~PHOSPHATE'>~~L1L~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE~~+~~ION~~'>~~SO4~~</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=GP1:GLUCOSAMINE+1-PHOSPHATE'>GP1</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ompF, cmlB, coa, cry, tolF, b0929, JW0912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), mlaA, vacJ, AGG09_21815, BB749_07690, BCB67_11070, BL143_09030, BN49_3944, PMK1_00224, SAMEA3531778_01593, SM30_03044, SM57_02930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ompF, cmlB, coa, cry, tolF, b0929, JW0912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), mlaA, vacJ, AGG09_21815, BB749_07690, BCB67_11070, BL143_09030, BN49_3944, PMK1_00224, SAMEA3531778_01593, SM30_03044, SM57_02930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [http://pdbe.org/5nur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [http://www.ebi.ac.uk/pdbsum/5nur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [http://pdbe.org/5nur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [http://www.ebi.ac.uk/pdbsum/5nur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5nur" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5nur" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Porin 3D structures\|Porin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Abellon-Ruiz, J]]		[[Category: Abellon-Ruiz, J]]
	[[Category: Basle, A]]		[[Category: Basle, A]]

OCA at 06:01, 1 November 2017

OCA — Wed, 01 Nov 2017 06:01:23 GMT

←Older revision		Revision as of 06:01, 1 November 2017
Line 3:		Line 3:
	<StructureSection load='5nur' size='340' side='right' caption='[[5nur]], [[Resolution\|resolution]] 3.29Å' scene=''>		<StructureSection load='5nur' size='340' side='right' caption='[[5nur]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NUR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=L1L:[(2R,3R,4R,5S,6R)-3-AZANYL-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]+DIHYDROGEN+PHOSPHATE'>L1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=L1L:[(2R,3R,4R,5S,6R)-3-AZANYL-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]+DIHYDROGEN+PHOSPHATE'>L1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ompF, cmlB, coa, cry, tolF, b0929, JW0912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), mlaA, vacJ, AGG09_21815, BB749_07690, BCB67_11070, BL143_09030, BN49_3944, PMK1_00224, SAMEA3531778_01593, SM30_03044, SM57_02930 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [http://pdbe.org/5nur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [http://www.ebi.ac.uk/pdbsum/5nur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [http://pdbe.org/5nur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [http://www.ebi.ac.uk/pdbsum/5nur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI]] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>		[[http://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI]] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Gram-negative bacterial outer membrane (OM) is a unique bilayer that forms an efficient permeation barrier to protect the cell from noxious compounds 1,2 . The defining characteristic of the OM is lipid asymmetry, with phospholipids comprising the inner leaflet and lipopolysaccharides comprising the outer leaflet 1-3 . This asymmetry is maintained by the Mla pathway, a six-component system that is widespread in Gram-negative bacteria and is thought to mediate retrograde transport of misplaced phospholipids from the outer leaflet of the OM to the cytoplasmic membrane 4 . The OM lipoprotein MlaA performs the first step in this process via an unknown mechanism that does not require external energy input. Here we show, using X-ray crystallography, molecular dynamics simulations and in vitro and in vivo functional assays, that MlaA is a monomeric alpha-helical OM protein that functions as a phospholipid translocation channel, forming a ~20-A-thick doughnut embedded in the inner leaflet of the OM with a central, amphipathic pore. This architecture prevents access of inner leaflet phospholipids to the pore, but allows outer leaflet phospholipids to bind to a pronounced ridge surrounding the channel, followed by diffusion towards the periplasmic space. Enterobacterial MlaA proteins form stable complexes with OmpF/C 5,6 , but the porins do not appear to play an active role in phospholipid transport. MlaA represents a lipid transport protein that selectively removes outer leaflet phospholipids to help maintain the essential barrier function of the bacterial OM.The crystal structure of MlaA, coupled with simulations of its interaction with phospholipids, elucidates how this outer membrane lipoprotein acts as a phospholipid translocation channel to maintain the asymmetric composition of the outer membrane.
		+
		+	Structural basis for maintenance of bacterial outer membrane lipid asymmetry.,Abellon-Ruiz J, Kaptan SS, Basle A, Claudi B, Bumann D, Kleinekathofer U, van den Berg B Nat Microbiol. 2017 Oct 16. doi: 10.1038/s41564-017-0046-x. PMID:29038444<ref>PMID:29038444</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5nur" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Abellon-Ruiz, J]]		[[Category: Abellon-Ruiz, J]]
	[[Category: Basle, A]]		[[Category: Basle, A]]

OCA at 07:13, 25 October 2017

OCA — Wed, 25 Oct 2017 07:13:42 GMT

←Older revision		Revision as of 07:13, 25 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5nur ~~is ON HOLD until Paper Publication~~	+	==Structural basis for maintenance of bacterial outer membrane lipid asymmetry==
-		+	<StructureSection load='5nur' size='340' side='right' caption='[[5nur]], [[Resolution\|resolution]] 3.29Å' scene=''>
-	~~Authors~~: ~~Abellon~~-~~Ruiz, J~~.~~, Kaptan, S~~.S., ~~Basle~~, A., ~~Claudi~~, B., ~~Bumann~~, D., ~~Kleinekathofer~~, U., ~~van den Berg~~, B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5nur]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NUR FirstGlance]. <br>
-	~~Description~~: ~~Structural basis for maintenance of bacterial outer membrane lipid asymmetry~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=L1L:[(2R,3R,4R,5S,6R)-3-AZANYL-6-(HYDROXYMETHYL)-4,5-BIS(OXIDANYL)OXAN-2-YL]+DIHYDROGEN+PHOSPHATE'>L1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z9M:2-AMINO-2-DEOXY-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>Z9M</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nur OCA], [http://pdbe.org/5nur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nur RCSB], [http://www.ebi.ac.uk/pdbsum/5nur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nur ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Kaptan~~, S.S]]	+	</table>
-	[~~[Category~~: ~~Van Den Berg~~, B]]	+	== Function ==
-	[[~~Category~~: ~~Kleinekathofer, U~~]]	+	[[http://www.uniprot.org/uniprot/OMPF_ECOLI OMPF_ECOLI]] Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2.<ref>PMID:19721064</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Abellon-Ruiz, J]]		[[Category: Abellon-Ruiz, J]]
		+	[[Category: Basle, A]]
		+	[[Category: Berg, B van den]]
	[[Category: Bumann, D]]		[[Category: Bumann, D]]
	[[Category: Claudi, B]]		[[Category: Claudi, B]]
-	[[Category: ~~Basle~~, A]]	+	[[Category: Kaptan, S S]]
		+	[[Category: Kleinekathofer, U]]
		+	[[Category: Lipid asymmetry]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Membrane protein]]
		+	[[Category: Outer membrane]]
		+	[[Category: Phospholipid translocation]]

OCA at 11:44, 27 September 2017

OCA — Wed, 27 Sep 2017 11:44:37 GMT

←Older revision		Revision as of 11:44, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5nur is ON HOLD	+	The entry 5nur is ON HOLD until Paper Publication

	Authors: Abellon-Ruiz, J., Kaptan, S.S., Basle, A., Claudi, B., Bumann, D., Kleinekathofer, U., van den Berg, B.		Authors: Abellon-Ruiz, J., Kaptan, S.S., Basle, A., Claudi, B., Bumann, D., Kleinekathofer, U., van den Berg, B.

OCA: Protected "5nur" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2017 09:22:48 GMT

Protected "5nur" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:22, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5nur is ON HOLD Authors: Abellon-Ruiz, J., Kaptan, S.S., Basle, A., Claudi, B., Bumann, D., Kleinekathofer, U., van den Berg, B. Description: Struc...

OCA — Wed, 10 May 2017 09:22:47 GMT

New page: '''Unreleased structure''' The entry 5nur is ON HOLD Authors: Abellon-Ruiz, J., Kaptan, S.S., Basle, A., Claudi, B., Bumann, D., Kleinekathofer, U., van den Berg, B. Description: Struc...

New page

'''Unreleased structure'''

The entry 5nur is ON HOLD

Authors: Abellon-Ruiz, J., Kaptan, S.S., Basle, A., Claudi, B., Bumann, D., Kleinekathofer, U., van den Berg, B.

Description: Structural basis for maintenance of bacterial outer membrane lipid asymmetry
[[Category: Unreleased Structures]]
[[Category: Kaptan, S.S]]
[[Category: Van Den Berg, B]]
[[Category: Kleinekathofer, U]]
[[Category: Abellon-Ruiz, J]]
[[Category: Bumann, D]]
[[Category: Claudi, B]]
[[Category: Basle, A]]