5nva - Revision history

OCA at 12:10, 22 November 2023

OCA — Wed, 22 Nov 2023 12:10:12 GMT

←Older revision		Revision as of 12:10, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5nva' size='340' side='right'caption='[[5nva]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='5nva' size='340' side='right'caption='[[5nva]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nva]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Promh Promh~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_mirabilis_HI4320 Proteus mirabilis HI4320]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NVA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NA:SODIUM+ION'>NA</scene~~>, ~~<scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PMI2976 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=529507 PROMH])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nva OCA], [~~http~~://pdbe.org/5nva PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nva RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nva PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nva ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nva OCA], [https://pdbe.org/5nva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nva RCSB], [https://www.ebi.ac.uk/pdbsum/5nva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nva ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B4EZY7_PROMH B4EZY7_PROMH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Promh~~]]	+	[[Category: Proteus mirabilis HI4320]]
-	[[Category: Abramson, J]]	+	[[Category: Abramson J]]
-	[[Category: Dobson, R]]	+	[[Category: Dobson R]]
-	[[Category: Dunevall, E]]	+	[[Category: Dunevall E]]
-	[[Category: Friemann, R]]	+	[[Category: Friemann R]]
-	[[Category: Goyal, P]]	+	[[Category: Goyal P]]
-	[[Category: Grabe, M]]	+	[[Category: Grabe M]]
-	[[Category: North~~, R A~~]]	+	[[Category: North RA]]
-	[[Category: Ramaswamy, S]]	+	[[Category: Ramaswamy S]]
-	[[Category: Wahlgren~~, W Y]]~~	+	[[Category: Wahlgren WY]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Membrane transporter]]~~	+
-	~~[[Category: Outward-open]]~~	+
-	~~[[Category: Sialic acid]]~~	+
-	~~[[Category: Sodium-coupled~~]]	+

OCA at 06:48, 16 October 2019

OCA — Wed, 16 Oct 2019 06:48:23 GMT

←Older revision		Revision as of 06:48, 16 October 2019
Line 1:		Line 1:

	==Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site==		==Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site==
-	<StructureSection load='5nva' size='340' side='right' caption='[[5nva]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='5nva' size='340' side='right'caption='[[5nva]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5nva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Promh Promh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVA FirstGlance]. <br>		<table><tr><td colspan='2'>[[5nva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Promh Promh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVA FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Promh]]		[[Category: Promh]]
	[[Category: Abramson, J]]		[[Category: Abramson, J]]

OCA at 05:47, 16 May 2018

OCA — Wed, 16 May 2018 05:47:52 GMT

←Older revision		Revision as of 05:47, 16 May 2018
Line 3:		Line 3:
	<StructureSection load='5nva' size='340' side='right' caption='[[5nva]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='5nva' size='340' side='right' caption='[[5nva]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nva]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Promh Promh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PMI2976 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529507 PROMH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nva OCA], [http://pdbe.org/5nva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nva RCSB], [http://www.ebi.ac.uk/pdbsum/5nva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nva ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nva OCA], [http://pdbe.org/5nva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nva RCSB], [http://www.ebi.ac.uk/pdbsum/5nva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nva ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 A resolution structure and subsequent characterisation of SiaT, a sialic acid transporter from Proteus mirabilis. SiaT is a secondary active transporter of the sodium solute symporter (SSS) family, which use Na(+) gradients to drive the uptake of extracellular substrates. SiaT adopts the LeuT-fold and is in an outward-open conformation in complex with the sialic acid N-acetylneuraminic acid and two Na(+) ions. One Na(+) binds to the conserved Na2 site, while the second Na(+) binds to a new position, termed Na3, which is conserved in many SSS family members. Functional and molecular dynamics studies validate the substrate-binding site and demonstrate that both Na(+) sites regulate N-acetylneuraminic acid transport.
		+
		+	Substrate-bound outward-open structure of a Na(+)-coupled sialic acid symporter reveals a new Na(+) site.,Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R Nat Commun. 2018 May 1;9(1):1753. doi: 10.1038/s41467-018-04045-7. PMID:29717135<ref>PMID:29717135</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5nva" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Promh]]
	[[Category: Abramson, J]]		[[Category: Abramson, J]]
	[[Category: Dobson, R]]		[[Category: Dobson, R]]

OCA at 05:51, 4 April 2018

OCA — Wed, 04 Apr 2018 05:51:56 GMT

←Older revision		Revision as of 05:51, 4 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5nva is ON HOLD~~	+	==Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site==
-		+	<StructureSection load='5nva' size='340' side='right' caption='[[5nva]], [[Resolution\|resolution]] 2.26Å' scene=''>
-	~~Authors: Wahlgren, W.Y., North, R.A., Dunevall, E., Goyal, P., Grabe, M., Dobson, R., Abramson, J., Ramaswamy, S., Friemann, R.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5nva]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVA FirstGlance]. <br>
-	~~Description:~~ Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nva OCA], [http://pdbe.org/5nva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nva RCSB], [http://www.ebi.ac.uk/pdbsum/5nva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nva ProSAT]</span></td></tr>
-	[[Category: ~~Ramaswamy~~, S]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Abramson, J]]
	[[Category: Dobson, R]]		[[Category: Dobson, R]]
		+	[[Category: Dunevall, E]]
		+	[[Category: Friemann, R]]
	[[Category: Goyal, P]]		[[Category: Goyal, P]]
-	[[Category: Wahlgren, W.Y]]
-	[[Category: Friemann, R]]
-	[[Category: Abramson, J]]
-	[[Category: Dunevall, E]]
-	[[Category: North, R.A]]
	[[Category: Grabe, M]]		[[Category: Grabe, M]]
		+	[[Category: North, R A]]
		+	[[Category: Ramaswamy, S]]
		+	[[Category: Wahlgren, W Y]]
		+	[[Category: Membrane protein]]
		+	[[Category: Membrane transporter]]
		+	[[Category: Outward-open]]
		+	[[Category: Sialic acid]]
		+	[[Category: Sodium-coupled]]

OCA: Protected "5nva" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2017 09:27:22 GMT

Protected "5nva" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:27, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5nva is ON HOLD Authors: Wahlgren, W.Y., North, R.A., Dunevall, E., Goyal, P., Grabe, M., Dobson, R., Abramson, J., Ramaswamy, S., Friemann, R. Des...

OCA — Wed, 10 May 2017 09:27:21 GMT

New page: '''Unreleased structure''' The entry 5nva is ON HOLD Authors: Wahlgren, W.Y., North, R.A., Dunevall, E., Goyal, P., Grabe, M., Dobson, R., Abramson, J., Ramaswamy, S., Friemann, R. Des...

New page

'''Unreleased structure'''

The entry 5nva is ON HOLD

Authors: Wahlgren, W.Y., North, R.A., Dunevall, E., Goyal, P., Grabe, M., Dobson, R., Abramson, J., Ramaswamy, S., Friemann, R.

Description: Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site
[[Category: Unreleased Structures]]
[[Category: Ramaswamy, S]]
[[Category: Dobson, R]]
[[Category: Goyal, P]]
[[Category: Wahlgren, W.Y]]
[[Category: Friemann, R]]
[[Category: Abramson, J]]
[[Category: Dunevall, E]]
[[Category: North, R.A]]
[[Category: Grabe, M]]