5nvs - Revision history

OCA at 12:10, 22 November 2023

OCA — Wed, 22 Nov 2023 12:10:45 GMT

←Older revision		Revision as of 12:10, 22 November 2023
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	<SX load='5nvs' size='340' side='right' viewer='molstar' caption='[[5nvs]], [[Resolution\|resolution]] 8.40Å' scene=''>		<SX load='5nvs' size='340' side='right' viewer='molstar' caption='[[5nvs]], [[Resolution\|resolution]] 8.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nvs]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5NVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nvs]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NVS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=UNK:UNKNOWN'>UNK</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8.4Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5nvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvs OCA], [~~http~~://pdbe.org/5nvs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nvs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nvs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvs OCA], [https://pdbe.org/5nvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nvs RCSB], [https://www.ebi.ac.uk/pdbsum/5nvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carter~~, A P~~]]	+	[[Category: Carter AP]]
-	[[Category: Foster~~, H E~~]]	+	[[Category: Foster HE]]
-	[[Category: Zhang, K]]	+	[[Category: Zhang K]]
-	~~[[Category: Dynein]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Tail complex~~]]	+

OCA at 21:20, 10 April 2020

OCA — Fri, 10 Apr 2020 21:20:11 GMT

←Older revision		Revision as of 21:20, 10 April 2020
Line 3:		Line 3:
	<SX load='5nvs' size='340' side='right' viewer='molstar' caption='[[5nvs]], [[Resolution\|resolution]] 8.40Å' scene=''>		<SX load='5nvs' size='340' side='right' viewer='molstar' caption='[[5nvs]], [[Resolution\|resolution]] 8.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nvs]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nvs]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NVS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvs OCA], [http://pdbe.org/5nvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvs RCSB], [http://www.ebi.ac.uk/pdbsum/5nvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvs OCA], [http://pdbe.org/5nvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvs RCSB], [http://www.ebi.ac.uk/pdbsum/5nvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:19, 6 March 2020

OCA — Fri, 06 Mar 2020 19:19:24 GMT

←Older revision		Revision as of 19:19, 6 March 2020
Line 1:		Line 1:

	==Human cytoplasmic dynein-1 tail in the twisted N-terminus state==		==Human cytoplasmic dynein-1 tail in the twisted N-terminus state==
-	<~~StructureSection~~ load='5nvs' size='340' side='right' caption='[[5nvs]], [[Resolution\|resolution]] 8.40Å' scene=''>	+	<SX load='5nvs' size='340' side='right' viewer='molstar' caption='[[5nvs]], [[Resolution\|resolution]] 8.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nvs]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nvs]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvs OCA], [http://pdbe.org/5nvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvs RCSB], [http://www.ebi.ac.uk/pdbsum/5nvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvs OCA], [http://pdbe.org/5nvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvs RCSB], [http://www.ebi.ac.uk/pdbsum/5nvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvs ProSAT]</span></td></tr>
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	</div>		</div>
	<div class="pdbe-citations 5nvs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5nvs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dynein 3D structures\|Dynein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Carter, A P]]		[[Category: Carter, A P]]
	[[Category: Foster, H E]]		[[Category: Foster, H E]]

OCA at 04:14, 30 August 2017

OCA — Wed, 30 Aug 2017 04:14:57 GMT

←Older revision		Revision as of 04:14, 30 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5nvs is ~~ON HOLD~~	+	==Human cytoplasmic dynein-1 tail in the twisted N-terminus state==
		+	<StructureSection load='5nvs' size='340' side='right' caption='[[5nvs]], [[Resolution\|resolution]] 8.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5nvs]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVS FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvs OCA], [http://pdbe.org/5nvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvs RCSB], [http://www.ebi.ac.uk/pdbsum/5nvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvs ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we present a cryoelectron microscopy structure of the complete 1.4-megadalton human dynein-1 complex in an inhibited state known as the phi-particle. We reveal the 3D structure of the cargo binding dynein tail and show how self-dimerization of the motor domains locks them in a conformation with low microtubule affinity. Disrupting motor dimerization with structure-based mutagenesis drives dynein-1 into an open form with higher affinity for both microtubules and dynactin. We find the open form is also inhibited for movement and that dynactin relieves this by reorienting the motor domains to interact correctly with microtubules. Our model explains how dynactin binding to the dynein-1 tail directly stimulates its motor activity.

-	~~Authors: Zhang~~, K., Foster, ~~H.E~~, ~~Carter~~, A.P.	+	Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.,Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP Cell. 2017 Jun 15;169(7):1303-1314.e18. doi: 10.1016/j.cell.2017.05.025. Epub, 2017 Jun 8. PMID:28602352<ref>PMID:28602352</ref>

-	~~Description: Human cytoplasmic dynein-1 tail in~~ the ~~twisted N~~-~~terminus state~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5nvs" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carter, A P]]
		+	[[Category: Foster, H E]]
	[[Category: Zhang, K]]		[[Category: Zhang, K]]
-	[[Category: ~~Foster, H.E, Carter, A.P~~]]	+	[[Category: Dynein]]
		+	[[Category: Motor protein]]
		+	[[Category: Tail complex]]

OCA: Protected "5nvs" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2017 09:28:27 GMT

Protected "5nvs" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:28, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5nvs is ON HOLD Authors: Zhang, K., Foster, H.E, Carter, A.P. Description: Human cytoplasmic dynein-1 tail in the twisted N-terminus state [[Catego...

OCA — Wed, 10 May 2017 09:28:26 GMT

New page: '''Unreleased structure''' The entry 5nvs is ON HOLD Authors: Zhang, K., Foster, H.E, Carter, A.P. Description: Human cytoplasmic dynein-1 tail in the twisted N-terminus state [[Catego...

New page

'''Unreleased structure'''

The entry 5nvs is ON HOLD

Authors: Zhang, K., Foster, H.E, Carter, A.P.

Description: Human cytoplasmic dynein-1 tail in the twisted N-terminus state
[[Category: Unreleased Structures]]
[[Category: Zhang, K]]
[[Category: Foster, H.E, Carter, A.P]]