5nxc - Revision history

OCA at 12:14, 22 November 2023

OCA — Wed, 22 Nov 2023 12:14:21 GMT

←Older revision		Revision as of 12:14, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5nxc' size='340' side='right'caption='[[5nxc]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='5nxc' size='340' side='right'caption='[[5nxc]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nxc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5NXC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NXC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DB:(2~{R})-2-AZANYL-2-CYCLOHEXYL-~{N}-[2-(1-METHYLPYRAZOL-4-YL)-9-OXIDANYLIDENE-3,10,11-TRIAZATRICYCLO[6.4.1.0^{4,13}]TRIDECA-1,4,6,8(13),11-PENTAEN-6-YL]ETHANAMIDE'>9DB</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIMK1, LIMK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DB:(2~{R})-2-AZANYL-2-CYCLOHEXYL-~{N}-[2-(1-METHYLPYRAZOL-4-YL)-9-OXIDANYLIDENE-3,10,11-TRIAZATRICYCLO[6.4.1.0^{4,13}]TRIDECA-1,4,6,8(13),11-PENTAEN-6-YL]ETHANAMIDE'>9DB</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxc OCA], [https://pdbe.org/5nxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nxc RCSB], [https://www.ebi.ac.uk/pdbsum/5nxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5nxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxc OCA], [~~http~~://pdbe.org/5nxc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nxc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nxc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN]] Williams syndrome. Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.	+	[https://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN] Williams syndrome. Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN]] Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.<ref>PMID:10196227</ref> <ref>PMID:10436159</ref> <ref>PMID:11832213</ref> <ref>PMID:12807904</ref> <ref>PMID:15660133</ref> <ref>PMID:16230460</ref> <ref>PMID:18028908</ref>	+	[https://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN] Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.<ref>PMID:10196227</ref> <ref>PMID:10436159</ref> <ref>PMID:11832213</ref> <ref>PMID:12807904</ref> <ref>PMID:15660133</ref> <ref>PMID:16230460</ref> <ref>PMID:18028908</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Bullock AN]]
-	[[Category: Bullock~~, A N~~]]	+	[[Category: Bushell S]]
-	[[Category: Bushell, S]]	+	[[Category: Carpenter EP]]
-	[[Category: Carpenter~~, E P]]~~	+	[[Category: Edwards AM]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Knapp S]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Mathea S]]
-	[[Category: Knapp, S]]	+	[[Category: Pike ACW]]
-	[[Category: Mathea, S]]	+	[[Category: Salah E]]
-	[[Category: Pike~~, A C.W~~]]	+	[[Category: Von Delft F]]
-	[[Category: Salah, E]]	+
-	[[Category: ~~Kinase actin cytoskeleton inhibitor]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:13, 26 August 2020

OCA — Wed, 26 Aug 2020 12:13:43 GMT

←Older revision		Revision as of 12:13, 26 August 2020
Line 1:		Line 1:

	==LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736==		==LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736==
-	<StructureSection load='5nxc' size='340' side='right' caption='[[5nxc]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='5nxc' size='340' side='right'caption='[[5nxc]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nxc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NXC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nxc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NXC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9DB:(2~{R})-2-AZANYL-2-CYCLOHEXYL-~{N}-[2-(1-METHYLPYRAZOL-4-YL)-9-OXIDANYLIDENE-3,10,11-TRIAZATRICYCLO[6.4.1.0^{4,13}]TRIDECA-1,4,6,8(13),11-PENTAEN-6-YL]ETHANAMIDE'>9DB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DB:(2~{R})-2-AZANYL-2-CYCLOHEXYL-~{N}-[2-(1-METHYLPYRAZOL-4-YL)-9-OXIDANYLIDENE-3,10,11-TRIAZATRICYCLO[6.4.1.0^{4,13}]TRIDECA-1,4,6,8(13),11-PENTAEN-6-YL]ETHANAMIDE'>9DB</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIMK1, LIMK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxc OCA], [http://pdbe.org/5nxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxc RCSB], [http://www.ebi.ac.uk/pdbsum/5nxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxc OCA], [http://pdbe.org/5nxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxc RCSB], [http://www.ebi.ac.uk/pdbsum/5nxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxc ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 13:47, 24 May 2017

OCA — Wed, 24 May 2017 13:47:28 GMT

←Older revision		Revision as of 13:47, 24 May 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5nxc ~~is ON HOLD~~	+	==LIM Domain Kinase 1 (LIMK1) In Complex With PF-00477736==
-		+	<StructureSection load='5nxc' size='340' side='right' caption='[[5nxc]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~Authors~~: ~~Mathea, S~~.~~, Salah, E~~., ~~Pike~~, A.C.W., ~~Bushell~~, S., ~~Carpenter~~, E.P., ~~von Delft, F~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.M., ~~Bountra, C~~., ~~Bullock~~, A.N., ~~Knapp, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5nxc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NXC FirstGlance]. <br>
-	~~Description: LIM Domain Kinase (LIMK1) In Complex With PF-00477736~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9DB:(2~{R})-2-AZANYL-2-CYCLOHEXYL-~{N}-[2-(1-METHYLPYRAZOL-4-YL)-9-OXIDANYLIDENE-3,10,11-TRIAZATRICYCLO[6.4.1.0^{4,13}]TRIDECA-1,4,6,8(13),11-PENTAEN-6-YL]ETHANAMIDE'>9DB</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	[[~~Category~~: ~~Mathea, S~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxc OCA], [http://pdbe.org/5nxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxc RCSB], [http://www.ebi.ac.uk/pdbsum/5nxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxc ProSAT]</span></td></tr>
-	[[Category: ~~Pike, A.C.W~~]]	+	</table>
-	[[Category: Arrowsmith, C.H]]	+	== Disease ==
-	[[Category: ~~Von Delft~~, F]]	+	[[http://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN]] Williams syndrome. Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
-	[[Category: Bullock, A.N]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN]] Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.<ref>PMID:10196227</ref> <ref>PMID:10436159</ref> <ref>PMID:11832213</ref> <ref>PMID:12807904</ref> <ref>PMID:15660133</ref> <ref>PMID:16230460</ref> <ref>PMID:18028908</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Bullock, A N]]
	[[Category: Bushell, S]]		[[Category: Bushell, S]]
		+	[[Category: Carpenter, E P]]
		+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A M]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]
-	[[Category: ~~Edwards~~, A.M]]	+	[[Category: Mathea, S]]
		+	[[Category: Pike, A C.W]]
	[[Category: Salah, E]]		[[Category: Salah, E]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Kinase actin cytoskeleton inhibitor]]
-	[[Category: ~~Carpenter, E.P~~]]	+	[[Category: Transferase]]

OCA: Protected "5nxc" [edit=sysop:move=sysop]

OCA — Wed, 17 May 2017 12:23:32 GMT

Protected "5nxc" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:23, 17 May 2017

OCA: New page: '''Unreleased structure''' The entry 5nxc is ON HOLD Authors: Mathea, S., Salah, E., Pike, A.C.W., Bushell, S., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra,...

OCA — Wed, 17 May 2017 12:23:31 GMT

New page: '''Unreleased structure''' The entry 5nxc is ON HOLD Authors: Mathea, S., Salah, E., Pike, A.C.W., Bushell, S., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra,...

New page

'''Unreleased structure'''

The entry 5nxc is ON HOLD

Authors: Mathea, S., Salah, E., Pike, A.C.W., Bushell, S., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Knapp, S.

Description: LIM Domain Kinase (LIMK1) In Complex With PF-00477736
[[Category: Unreleased Structures]]
[[Category: Mathea, S]]
[[Category: Pike, A.C.W]]
[[Category: Arrowsmith, C.H]]
[[Category: Von Delft, F]]
[[Category: Bullock, A.N]]
[[Category: Bushell, S]]
[[Category: Knapp, S]]
[[Category: Edwards, A.M]]
[[Category: Salah, E]]
[[Category: Bountra, C]]
[[Category: Carpenter, E.P]]