5nxx - Revision history

OCA at 12:15, 22 November 2023

OCA — Wed, 22 Nov 2023 12:15:39 GMT

←Older revision		Revision as of 12:15, 22 November 2023
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	<StructureSection load='5nxx' size='340' side='right'caption='[[5nxx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5nxx' size='340' side='right'caption='[[5nxx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nxx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5NXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NXX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=3Q7:(trimethylarsonio)acetate'>3Q7</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[2b4l\|2b4l]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3Q7:(trimethylarsonio)acetate'>3Q7</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxx OCA], [~~http~~://pdbe.org/5nxx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5nxx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5nxx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxx OCA], [https://pdbe.org/5nxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nxx RCSB], [https://www.ebi.ac.uk/pdbsum/5nxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/OPUAC_BACSU OPUAC_BACSU] Involved in a multicomponent binding-protein-dependent transport system for glycine betaine.<ref>PMID:7622480</ref> <ref>PMID:8752321</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5nxx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5nxx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ABC transporter 3D structures\|ABC transporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bremer, E]]	+	[[Category: Bremer E]]
-	[[Category: Hofmann, T]]	+	[[Category: Hofmann T]]
-	[[Category: Schmitt, L]]	+	[[Category: Schmitt L]]
-	[[Category: Smits, S]]	+	[[Category: Smits S]]
-	~~[[Category: B. subtili]]~~	+
-	~~[[Category: Substrate binding protein arseen]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 12:14, 26 August 2020

OCA — Wed, 26 Aug 2020 12:14:02 GMT

←Older revision		Revision as of 12:14, 26 August 2020
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	==Crystal structure of OpuAC from B. subtilis in complex with Arsenobetaine==		==Crystal structure of OpuAC from B. subtilis in complex with Arsenobetaine==
-	<StructureSection load='5nxx' size='340' side='right' caption='[[5nxx]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5nxx' size='340' side='right'caption='[[5nxx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5nxx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5nxx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Q7:(trimethylarsonio)acetate'>3Q7</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3Q7:(trimethylarsonio)acetate'>3Q7</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b4l\|2b4l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b4l\|2b4l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxx OCA], [http://pdbe.org/5nxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxx RCSB], [http://www.ebi.ac.uk/pdbsum/5nxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxx OCA], [http://pdbe.org/5nxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxx RCSB], [http://www.ebi.ac.uk/pdbsum/5nxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bremer, E]]		[[Category: Bremer, E]]
	[[Category: Hofmann, T]]		[[Category: Hofmann, T]]

OCA at 06:29, 28 March 2018

OCA — Wed, 28 Mar 2018 06:29:32 GMT

←Older revision		Revision as of 06:29, 28 March 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5nxx is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of OpuAC from B. subtilis in complex with Arsenobetaine==
		+	<StructureSection load='5nxx' size='340' side='right' caption='[[5nxx]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5nxx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NXX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Q7:(trimethylarsonio)acetate'>3Q7</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b4l\|2b4l]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxx OCA], [http://pdbe.org/5nxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxx RCSB], [http://www.ebi.ac.uk/pdbsum/5nxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxx ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Arsenic, a highly cytotoxic and cancerogenic metalloid, is brought into the biosphere through geochemical sources and anthropogenic activities. A global biogeochemical arsenic biotransformation cycle exists in which inorganic arsenic species are transformed into organoarsenicals, which are subsequently mineralized again into inorganic arsenic compounds. Microorganisms contribute to this biotransformation process greatly and one of the organoarsenicals synthesized and degraded in this cycle is arsenobetaine. Its nitrogen-containing homologue glycine betaine is probably the most frequently used compatible solute on Earth. Arsenobetaine is found in marine and terrestrial habitats and even in deep-sea hydrothermal vent ecosystems. Despite its ubiquitous occurrence, the biological function of arsenobetaine has not been comprehensively addressed. Using Bacillus subtilis as a well-understood platform for the study of microbial osmostress adjustment systems, we ascribe here to arsenobetaine both a protective function against high osmolarity and a cytoprotective role against extremes in low and high growth temperatures. We define a biosynthetic route for arsenobetaine from the precursor arsenocholine that relies on enzymes and genetic regulatory circuits for glycine betaine formation from choline, identify the uptake systems for arsenobetaine and arsenocholine, and describe crystal structures of ligand-binding proteins from the OpuA and OpuB ABC transporters complexed with either arsenobetaine or arsenocholine.

-	~~Authors~~: ~~Hofmann~~, T., ~~Bremer~~, E., ~~Schmitt~~, L., ~~Smits, S~~.	+	Arsenobetaine: an ecophysiologically important organoarsenical confers cytoprotection against osmotic stress and growth temperature extremes.,Hoffmann T, Warmbold B, Smits SHJ, Tschapek B, Ronzheimer S, Bashir A, Chen C, Rolbetzki A, Pittelkow M, Jebbar M, Seubert A, Schmitt L, Bremer E Environ Microbiol. 2018 Jan;20(1):305-323. doi: 10.1111/1462-2920.13999. Epub, 2017 Dec 7. PMID:29159878<ref>PMID:29159878</ref>

-	~~Description: Crystal structure~~ of ~~OpuAC from B~~. ~~subtilis in complex with Arsenobetaine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5nxx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bremer, E]]		[[Category: Bremer, E]]
-	[[Category: Smits, S]]
-	[[Category: Schmitt, L]]
	[[Category: Hofmann, T]]		[[Category: Hofmann, T]]
		+	[[Category: Schmitt, L]]
		+	[[Category: Smits, S]]
		+	[[Category: B. subtili]]
		+	[[Category: Substrate binding protein arseen]]
		+	[[Category: Transport protein]]

OCA at 11:51, 27 September 2017

OCA — Wed, 27 Sep 2017 11:51:04 GMT

←Older revision		Revision as of 11:51, 27 September 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5nxx is ON HOLD	+	The entry 5nxx is ON HOLD until Paper Publication

	Authors: Hofmann, T., Bremer, E., Schmitt, L., Smits, S.		Authors: Hofmann, T., Bremer, E., Schmitt, L., Smits, S.

OCA: Protected "5nxx" [edit=sysop:move=sysop]

OCA — Wed, 17 May 2017 12:24:44 GMT

Protected "5nxx" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:24, 17 May 2017

OCA: New page: '''Unreleased structure''' The entry 5nxx is ON HOLD Authors: Hofmann, T., Bremer, E., Schmitt, L., Smits, S. Description: Crystal structure of OpuAC from B. subtilis in complex with A...

OCA — Wed, 17 May 2017 12:24:43 GMT

New page: '''Unreleased structure''' The entry 5nxx is ON HOLD Authors: Hofmann, T., Bremer, E., Schmitt, L., Smits, S. Description: Crystal structure of OpuAC from B. subtilis in complex with A...

New page

'''Unreleased structure'''

The entry 5nxx is ON HOLD

Authors: Hofmann, T., Bremer, E., Schmitt, L., Smits, S.

Description: Crystal structure of OpuAC from B. subtilis in complex with Arsenobetaine
[[Category: Unreleased Structures]]
[[Category: Bremer, E]]
[[Category: Smits, S]]
[[Category: Schmitt, L]]
[[Category: Hofmann, T]]