5o8k - Revision history

OCA at 09:36, 6 December 2023

OCA — Wed, 06 Dec 2023 09:36:51 GMT

←Older revision		Revision as of 09:36, 6 December 2023
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	<StructureSection load='5o8k' size='340' side='right'caption='[[5o8k]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5o8k' size='340' side='right'caption='[[5o8k]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5o8k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5O8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5o8k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O8K FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[http://en.wikipedia.org/wiki/DNA~~-~~directed_DNA_polymerase DNA-directed DNA polymerase]~~, ~~with EC number~~ [~~http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5o8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8k OCA], [~~http~~://pdbe.org/5o8k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5o8k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5o8k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8k OCA], [https://pdbe.org/5o8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o8k RCSB], [https://www.ebi.ac.uk/pdbsum/5o8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MD2L2_MOUSE MD2L2_MOUSE]] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (By similarity). [[http://www.uniprot.org/uniprot/REV3L_HUMAN REV3L_HUMAN]] Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.<ref>PMID:24449906</ref>	+	[https://www.uniprot.org/uniprot/MD2L2_MOUSE MD2L2_MOUSE] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (By similarity).
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA-directed DNA polymerase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Emamzadah, S]]	+	[[Category: Mus musculus]]
-	[[Category: Halazonetis, T]]	+	[[Category: Emamzadah S]]
-	[[Category: Huber, F]]	+	[[Category: Halazonetis T]]
-	[[Category: Tropia, L]]	+	[[Category: Huber F]]
-	~~[[Category: Dna polymerase zeta]]~~	+	[[Category: Tropia L]]
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Mad2l2]]~~	+
-	~~[[Category: Replication]]~~	+
-	~~[[Category: Rev7~~]]	+

OCA at 12:18, 26 August 2020

OCA — Wed, 26 Aug 2020 12:18:54 GMT

←Older revision		Revision as of 12:18, 26 August 2020
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	==Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895==		==Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895==
-	<StructureSection load='5o8k' size='340' side='right' caption='[[5o8k]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5o8k' size='340' side='right'caption='[[5o8k]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5o8k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5O8K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5o8k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5O8K FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5o8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8k OCA], [http://pdbe.org/5o8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o8k RCSB], [http://www.ebi.ac.uk/pdbsum/5o8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5o8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8k OCA], [http://pdbe.org/5o8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o8k RCSB], [http://www.ebi.ac.uk/pdbsum/5o8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Large Structures]]
	[[Category: Emamzadah, S]]		[[Category: Emamzadah, S]]
	[[Category: Halazonetis, T]]		[[Category: Halazonetis, T]]

OCA at 05:24, 27 June 2018

OCA — Wed, 27 Jun 2018 05:24:40 GMT

←Older revision		Revision as of 05:24, 27 June 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5o8k is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895==
-		+	<StructureSection load='5o8k' size='340' side='right' caption='[[5o8k]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5o8k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O8K FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8k OCA], [http://pdbe.org/5o8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o8k RCSB], [http://www.ebi.ac.uk/pdbsum/5o8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8k ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MD2L2_MOUSE MD2L2_MOUSE]] Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (By similarity). [[http://www.uniprot.org/uniprot/REV3L_HUMAN REV3L_HUMAN]] Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.<ref>PMID:24449906</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Emamzadah, S]]
		+	[[Category: Halazonetis, T]]
		+	[[Category: Huber, F]]
		+	[[Category: Tropia, L]]
		+	[[Category: Dna polymerase zeta]]
		+	[[Category: Dna replication]]
		+	[[Category: Mad2l2]]
		+	[[Category: Replication]]
		+	[[Category: Rev7]]

OCA: Protected "5o8k" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 12:09:34 GMT

Protected "5o8k" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:09, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5o8k is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 12:09:33 GMT

New page: '''Unreleased structure''' The entry 5o8k is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5o8k is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]