5o9k - Revision history

OCA at 09:37, 6 December 2023

OCA — Wed, 06 Dec 2023 09:37:42 GMT

←Older revision		Revision as of 09:37, 6 December 2023
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	<StructureSection load='5o9k' size='340' side='right'caption='[[5o9k]], [[Resolution\|resolution]] 4.01Å' scene=''>		<StructureSection load='5o9k' size='340' side='right'caption='[[5o9k]], [[Resolution\|resolution]] 4.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5o9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5O9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5o9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O9K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.014Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9k OCA], [~~http~~://pdbe.org/5o9k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5o9k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5o9k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9k ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9k OCA], [https://pdbe.org/5o9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o9k RCSB], [https://www.ebi.ac.uk/pdbsum/5o9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TCTP_MOUSE TCTP_MOUSE]] Involved in calcium binding and microtubule stabilization.	+	[https://www.uniprot.org/uniprot/TCTP_MOUSE TCTP_MOUSE] Involved in calcium binding and microtubule stabilization.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Davies~~, A M~~]]	+	[[Category: Mus musculus]]
-	[[Category: Dore~~, K A~~]]	+	[[Category: Davies AM]]
-	[[Category: Gould~~, H J~~]]	+	[[Category: Dore KA]]
-	[[Category: Kashiwakura, J]]	+	[[Category: Gould HJ]]
-	[[Category: Kawakami, T]]	+	[[Category: Kashiwakura J]]
-	[[Category: McDonnell~~, J M~~]]	+	[[Category: Kawakami T]]
-	[[Category: Sutton~~, B J]]~~	+	[[Category: McDonnell JM]]
-	~~[[Category: Allergy]]~~	+	[[Category: Sutton BJ]]
-	~~[[Category: Fortilin]]~~	+
-	~~[[Category: Histamine releasing factor]]~~	+
-	~~[[Category: Hrf]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin e]]~~	+
-	~~[[Category: P21]]~~	+
-	~~[[Category: P23]]~~	+
-	~~[[Category: Tctp~~]]	+

OCA at 12:19, 26 August 2020

OCA — Wed, 26 Aug 2020 12:19:11 GMT

←Older revision		Revision as of 12:19, 26 August 2020
Line 1:		Line 1:

	==Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP)==		==Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP)==
-	<StructureSection load='5o9k' size='340' side='right' caption='[[5o9k]], [[Resolution\|resolution]] 4.01Å' scene=''>	+	<StructureSection load='5o9k' size='340' side='right'caption='[[5o9k]], [[Resolution\|resolution]] 4.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5o9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5O9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5o9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5O9K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9k OCA], [http://pdbe.org/5o9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o9k RCSB], [http://www.ebi.ac.uk/pdbsum/5o9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9k OCA], [http://pdbe.org/5o9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o9k RCSB], [http://www.ebi.ac.uk/pdbsum/5o9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Davies, A M]]		[[Category: Davies, A M]]
	[[Category: Dore, K A]]		[[Category: Dore, K A]]

OCA at 06:12, 20 December 2017

OCA — Wed, 20 Dec 2017 06:12:09 GMT

←Older revision		Revision as of 06:12, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5o9k is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP)==
		+	<StructureSection load='5o9k' size='340' side='right' caption='[[5o9k]], [[Resolution\|resolution]] 4.01Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5o9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O9K FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o9k OCA], [http://pdbe.org/5o9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o9k RCSB], [http://www.ebi.ac.uk/pdbsum/5o9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o9k ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TCTP_MOUSE TCTP_MOUSE]] Involved in calcium binding and microtubule stabilization.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In allergic disease, mast cell activation is conventionally triggered by allergen-mediated cross-linking of receptor-bound IgE on the cell surface. In addition to its diverse range of intracellular roles in apoptosis, cell proliferation and cancer, Histamine-Releasing Factor (HRF) also activates mast cells and basophils. A subset of IgE antibodies bind HRF through their Fab regions, and two IgE binding sites on HRF have been mapped. HRF can form dimers, and a disulphide-linked dimer is critical for activity. The current model for the activity of HRF in mast cell activation involves cross-linking of receptor-bound IgE by dimeric HRF, mediated by HRF/Fab interactions. HRF crystal and solution structures have provided little insight into either the formation of disulphide-linked HRF dimers or the ability of HRF to activate mast cells. We report the first crystal structure of murine HRF (mHRF) to 4.0A resolution, revealing a conserved fold. We also solved the structure of human HRF (hHRF) in two new crystal forms, one at the highest resolution (1.4A) yet reported. The high resolution hHRF structure reveals a disulphide-linked dimer, in which the two molecules are closely associated, and provides a model for the role of both human and murine HRF in mast cell activation.

-	~~Authors~~:	+	Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.,Dore KA, Kashiwakura JI, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM Mol Immunol. 2018 Jan;93:216-222. doi: 10.1016/j.molimm.2017.11.022. Epub 2017, Dec 5. PMID:29216544<ref>PMID:29216544</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5o9k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Davies, A M]]
		+	[[Category: Dore, K A]]
		+	[[Category: Gould, H J]]
		+	[[Category: Kashiwakura, J]]
		+	[[Category: Kawakami, T]]
		+	[[Category: McDonnell, J M]]
		+	[[Category: Sutton, B J]]
		+	[[Category: Allergy]]
		+	[[Category: Fortilin]]
		+	[[Category: Histamine releasing factor]]
		+	[[Category: Hrf]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin e]]
		+	[[Category: P21]]
		+	[[Category: P23]]
		+	[[Category: Tctp]]

OCA: Protected "5o9k" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 12:11:20 GMT

Protected "5o9k" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:11, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5o9k is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 12:11:19 GMT

New page: '''Unreleased structure''' The entry 5o9k is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5o9k is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]