5oen - Revision history

OCA at 16:46, 13 December 2023

OCA — Wed, 13 Dec 2023 16:46:59 GMT

←Older revision		Revision as of 16:46, 13 December 2023
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	<StructureSection load='5oen' size='340' side='right'caption='[[5oen]], [[Resolution\|resolution]] 2.92Å' scene=''>		<StructureSection load='5oen' size='340' side='right'caption='[[5oen]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5OEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OEN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5oen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oen OCA], [~~http~~://pdbe.org/5oen PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5oen RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5oen PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5oen ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.919Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oen OCA], [https://pdbe.org/5oen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oen RCSB], [https://www.ebi.ac.uk/pdbsum/5oen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IRF9_MOUSE IRF9_MOUSE]] Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.	+	[https://www.uniprot.org/uniprot/IRF9_MOUSE IRF9_MOUSE] Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Panne, D~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Rengachari, S~~]]	+	[[Category: Panne D]]
-	[[Category: ~~Irf9]]~~	+	[[Category: Rengachari S]]
-	~~[[Category: Stat2]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 12:22, 26 August 2020

OCA — Wed, 26 Aug 2020 12:22:27 GMT

←Older revision		Revision as of 12:22, 26 August 2020
Line 1:		Line 1:

	==Crystal Structure of STAT2 in complex with IRF9==		==Crystal Structure of STAT2 in complex with IRF9==
-	<StructureSection load='5oen' size='340' side='right' caption='[[5oen]], [[Resolution\|resolution]] 2.92Å' scene=''>	+	<StructureSection load='5oen' size='340' side='right'caption='[[5oen]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OEN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5oen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oen OCA], [http://pdbe.org/5oen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oen RCSB], [http://www.ebi.ac.uk/pdbsum/5oen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oen ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5oen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oen OCA], [http://pdbe.org/5oen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oen RCSB], [http://www.ebi.ac.uk/pdbsum/5oen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5oen" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5oen" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interferon regulatory factor\|Interferon regulatory factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Panne, D]]		[[Category: Panne, D]]
	[[Category: Rengachari, S]]		[[Category: Rengachari, S]]

OCA at 18:23, 24 January 2018

OCA — Wed, 24 Jan 2018 18:23:08 GMT

←Older revision		Revision as of 18:23, 24 January 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5oen is ~~ON HOLD~~	+	==Crystal Structure of STAT2 in complex with IRF9==
		+	<StructureSection load='5oen' size='340' side='right' caption='[[5oen]], [[Resolution\|resolution]] 2.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5oen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OEN FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oen OCA], [http://pdbe.org/5oen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oen RCSB], [http://www.ebi.ac.uk/pdbsum/5oen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oen ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IRF9_MOUSE IRF9_MOUSE]] Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytokine signaling through the JAK/STAT pathway controls multiple cellular responses including growth, survival, differentiation, and pathogen resistance. An expansion in the gene regulatory repertoire controlled by JAK/STAT signaling occurs through the interaction of STATs with IRF transcription factors to form ISGF3, a complex that contains STAT1, STAT2, and IRF9 and regulates expression of IFN-stimulated genes. ISGF3 function depends on selective interaction between IRF9, through its IRF-association domain (IAD), with the coiled-coil domain (CCD) of STAT2. Here, we report the crystal structures of the IRF9-IAD alone and in a complex with STAT2-CCD. Despite similarity in the overall structure among respective paralogs, the surface features of the IRF9-IAD and STAT2-CCD have diverged to enable specific interaction between these family members. We derive a model for the ISGF3 complex bound to an ISRE DNA element and demonstrate that the observed interface between STAT2 and IRF9 is required for ISGF3 function in cells.

-	~~Authors~~:	+	Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function.,Rengachari S, Groiss S, Devos JM, Caron E, Grandvaux N, Panne D Proc Natl Acad Sci U S A. 2018 Jan 9. pii: 1718426115. doi:, 10.1073/pnas.1718426115. PMID:29317535<ref>PMID:29317535</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5oen" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Panne, D]]
		+	[[Category: Rengachari, S]]
		+	[[Category: Irf9]]
		+	[[Category: Stat2]]
		+	[[Category: Transcription]]

OCA: Protected "5oen" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 12:20:46 GMT

Protected "5oen" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:20, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5oen is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 12:20:45 GMT

New page: '''Unreleased structure''' The entry 5oen is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5oen is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]