5oh6 - Revision history

OCA at 16:50, 13 December 2023

OCA — Wed, 13 Dec 2023 16:50:12 GMT

←Older revision		Revision as of 16:50, 13 December 2023
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	==Legionella pneumophila RidL N-terminal domain lacking beta hairpin==		==Legionella pneumophila RidL N-terminal domain lacking beta hairpin==
-	<StructureSection load='5oh6' size='340' side='right' caption='[[5oh6]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='5oh6' size='340' side='right'caption='[[5oh6]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oh6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Legionella_pneumophila_subsp.~~_pneumophila_570-co-h~~ Legionella pneumophila subsp. pneumophila ~~570-co-h~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OH6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oh6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_ATCC_43290 Legionella pneumophila subsp. pneumophila ATCC 43290]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OH6 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~lp12_2303 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=933093 Legionella pneumophila subsp. pneumophila 570-CO-H])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5oh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oh6 OCA], [~~http~~://pdbe.org/5oh6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5oh6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5oh6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5oh6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oh6 OCA], [https://pdbe.org/5oh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oh6 RCSB], [https://www.ebi.ac.uk/pdbsum/5oh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oh6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Legionella pneumophila subsp. pneumophila ~~570-co-h~~]]	+	[[Category: Large Structures]]
-	[[Category: Baerlocher, K]]	+	[[Category: Legionella pneumophila subsp. pneumophila ATCC 43290]]
-	[[Category: Hilbi, H]]	+	[[Category: Baerlocher K]]
-	[[Category: Hohl, M]]	+	[[Category: Hilbi H]]
-	[[Category: Hutter~~, C A.J~~]]	+	[[Category: Hohl M]]
-	[[Category: Letourneur, F]]	+	[[Category: Hutter CAJ]]
-	[[Category: Seeger~~, M A~~]]	+	[[Category: Letourneur F]]
-	[[Category: Steiner, B]]	+	[[Category: Seeger MA]]
-	[[Category: Swart~~, A L~~]]	+	[[Category: Steiner B]]
-	[[Category: Welin, A]]	+	[[Category: Swart AL]]
-	~~[[Category: Novel alpha helical fold]]~~	+	[[Category: Welin A]]
-	~~[[Category: Toxin~~]]	+

OCA at 07:30, 29 November 2017

OCA — Wed, 29 Nov 2017 07:30:17 GMT

←Older revision		Revision as of 07:30, 29 November 2017
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	<StructureSection load='5oh6' size='340' side='right' caption='[[5oh6]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='5oh6' size='340' side='right' caption='[[5oh6]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oh6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OH6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oh6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_570-co-h Legionella pneumophila subsp. pneumophila 570-co-h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OH6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oh6 OCA], [http://pdbe.org/5oh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oh6 RCSB], [http://www.ebi.ac.uk/pdbsum/5oh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oh6 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lp12_2303 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=933093 Legionella pneumophila subsp. pneumophila 570-CO-H])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oh6 OCA], [http://pdbe.org/5oh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oh6 RCSB], [http://www.ebi.ac.uk/pdbsum/5oh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oh6 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Legionella pneumophila can cause Legionnaires' disease and replicates intracellularly in a distinct Legionella-containing vacuole (LCV). LCV formation is a complex process that involves a plethora of type IV-secreted effector proteins. The effector RidL binds the Vps29 retromer subunit, blocks retrograde vesicle trafficking, and promotes intracellular bacterial replication. Here, we reveal that the 29-kDa N-terminal domain of RidL (RidL2-281) adopts a "foot-like" fold comprising a protruding beta-hairpin at its "heel". The deletion of the beta-hairpin, the exchange to Glu of Ile170 in the beta-hairpin, or Leu152 in Vps29 abolishes the interaction in eukaryotic cells and in vitro. RidL2-281 or RidL displace the Rab7 GTPase-activating protein (GAP) TBC1D5 from the retromer and LCVs, respectively, and TBC1D5 promotes the intracellular growth of L. pneumophila. Thus, the hydrophobic beta-hairpin of RidL is critical for binding of the L. pneumophila effector to the Vps29 retromer subunit and displacement of the regulator TBC1D5.
		+
		+	Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.,Barlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA, Hilbi H Nat Commun. 2017 Nov 16;8(1):1543. doi: 10.1038/s41467-017-01512-5. PMID:29146912<ref>PMID:29146912</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5oh6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Legionella pneumophila subsp. pneumophila 570-co-h]]
	[[Category: Baerlocher, K]]		[[Category: Baerlocher, K]]
	[[Category: Hilbi, H]]		[[Category: Hilbi, H]]

OCA at 07:39, 22 November 2017

OCA — Wed, 22 Nov 2017 07:39:10 GMT

←Older revision		Revision as of 07:39, 22 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5oh6 is ~~ON HOLD until Paper Publication~~	+	==Legionella pneumophila RidL N-terminal domain lacking beta hairpin==
-		+	<StructureSection load='5oh6' size='340' side='right' caption='[[5oh6]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5oh6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OH6 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oh6 OCA], [http://pdbe.org/5oh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oh6 RCSB], [http://www.ebi.ac.uk/pdbsum/5oh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oh6 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Baerlocher, K]]
		+	[[Category: Hilbi, H]]
		+	[[Category: Hohl, M]]
		+	[[Category: Hutter, C A.J]]
		+	[[Category: Letourneur, F]]
		+	[[Category: Seeger, M A]]
		+	[[Category: Steiner, B]]
		+	[[Category: Swart, A L]]
		+	[[Category: Welin, A]]
		+	[[Category: Novel alpha helical fold]]
		+	[[Category: Toxin]]

OCA: Protected "5oh6" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 12:25:53 GMT

Protected "5oh6" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:25, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5oh6 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 12:25:52 GMT

New page: '''Unreleased structure''' The entry 5oh6 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5oh6 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]