5ojl - Revision history

OCA at 16:52, 13 December 2023

OCA — Wed, 13 Dec 2023 16:52:12 GMT

←Older revision		Revision as of 16:52, 13 December 2023
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	<StructureSection load='5ojl' size='340' side='right'caption='[[5ojl]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='5ojl' size='340' side='right'caption='[[5ojl]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ojl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5OJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ojl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OJL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9X5:5-methyl-7~{H}-benzo[d][2]benzazepine'>9X5</scene>, <scene name='pdbligand=TXP:1,4,5,6-TETRAHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE+PHOSPHATE'>TXP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ojl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojl OCA], [~~http~~://pdbe.org/5ojl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ojl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ojl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojl ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9X5:5-methyl-7~{H}-benzo[d][2]benzazepine'>9X5</scene>, <scene name='pdbligand=TXP:1,4,5,6-TETRAHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE+PHOSPHATE'>TXP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ojl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojl OCA], [https://pdbe.org/5ojl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ojl RCSB], [https://www.ebi.ac.uk/pdbsum/5ojl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q0CCT3_ASPTN Q0CCT3_ASPTN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aspergillus terreus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Grogan, G]]	+	[[Category: Grogan G]]
-	[[Category: Sharma, M]]	+	[[Category: Sharma M]]
-	~~[[Category: Imine reductase]]~~	+
-	~~[[Category: Nadph]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Reductive aminase~~]]	+

OCA at 12:23, 26 August 2020

OCA — Wed, 26 Aug 2020 12:23:51 GMT

←Older revision		Revision as of 12:23, 26 August 2020
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	==Imine Reductase from Aspergillus terreus in complex with NADPH4 and dibenz[c,e]azepine==		==Imine Reductase from Aspergillus terreus in complex with NADPH4 and dibenz[c,e]azepine==
-	<StructureSection load='5ojl' size='340' side='right' caption='[[5ojl]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='5ojl' size='340' side='right'caption='[[5ojl]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ojl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ojl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OJL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9X5:5-methyl-7~{H}-benzo[d][2]benzazepine'>9X5</scene>, <scene name='pdbligand=TXP:1,4,5,6-TETRAHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE+PHOSPHATE'>TXP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9X5:5-methyl-7~{H}-benzo[d][2]benzazepine'>9X5</scene>, <scene name='pdbligand=TXP:1,4,5,6-TETRAHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE+PHOSPHATE'>TXP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ojl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojl OCA], [http://pdbe.org/5ojl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ojl RCSB], [http://www.ebi.ac.uk/pdbsum/5ojl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ojl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojl OCA], [http://pdbe.org/5ojl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ojl RCSB], [http://www.ebi.ac.uk/pdbsum/5ojl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Grogan, G]]		[[Category: Grogan, G]]
	[[Category: Sharma, M]]		[[Category: Sharma, M]]

OCA at 05:27, 30 May 2018

OCA — Wed, 30 May 2018 05:27:20 GMT

←Older revision		Revision as of 05:27, 30 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ojl is ~~ON HOLD until Paper~~ Publication	+	==Imine Reductase from Aspergillus terreus in complex with NADPH4 and dibenz[c,e]azepine==
		+	<StructureSection load='5ojl' size='340' side='right' caption='[[5ojl]], [[Resolution\|resolution]] 1.56Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ojl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OJL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9X5:5-methyl-7~{H}-benzo[d][2]benzazepine'>9X5</scene>, <scene name='pdbligand=TXP:1,4,5,6-TETRAHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE+PHOSPHATE'>TXP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ojl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ojl OCA], [http://pdbe.org/5ojl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ojl RCSB], [http://www.ebi.ac.uk/pdbsum/5ojl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ojl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Biocatalytic retrosynthetic analysis of dibenz[c,e]azepines has highlighted the use of imine reductase (IRED) and omega-transaminase (omega-TA) biocatalysts to establish the key stereocentres of these molecules. Several enantiocomplementary IREDs were identified for the synthesis of (R)- and (S)-5-methyl-6,7-dihydro-5H-dibenz[c,e]azepine with excellent enantioselectivity, by reduction of the parent imines. Crystallographic evidence suggests that IREDs may be able to bind one conformer of the imine substrate such that, upon reduction, the major product conformer is generated directly. omega-TA biocatalysts were also successfully employed for the production of enantiopure 1-(2-bromophenyl)ethan-1-amine, thus enabling an orthogonal route for the installation of chirality into dibenz[c,e]azepine framework.

-	~~Authors: Sharma~~, M., ~~Grogan~~, G.	+	Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines.,France SP, Aleku GA, Sharma M, Mangas-Sanchez J, Howard RM, Steflik J, Kumar R, Adams RW, Slabu I, Crook R, Grogan G, Wallace TW, Turner NJ Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15589-15593. doi:, 10.1002/anie.201708453. Epub 2017 Nov 7. PMID:29024400<ref>PMID:29024400</ref>

-	~~Description: Imine Reductase from Aspergillus terreus in complex with NADPH4 and dibenz[c~~,~~e]azepine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Sharma, M]]~~	+	<div class="pdbe-citations 5ojl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Grogan, G]]		[[Category: Grogan, G]]
		+	[[Category: Sharma, M]]
		+	[[Category: Imine reductase]]
		+	[[Category: Nadph]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Reductive aminase]]

OCA: Protected "5ojl" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 12:30:29 GMT

Protected "5ojl" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:30, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5ojl is ON HOLD until Paper Publication Authors: Sharma, M., Grogan, G. Description: Imine Reductase from Aspergillus terreus in complex with NADPH...

OCA — Wed, 27 Sep 2017 12:30:28 GMT

New page: '''Unreleased structure''' The entry 5ojl is ON HOLD until Paper Publication Authors: Sharma, M., Grogan, G. Description: Imine Reductase from Aspergillus terreus in complex with NADPH...

New page

'''Unreleased structure'''

The entry 5ojl is ON HOLD until Paper Publication

Authors: Sharma, M., Grogan, G.

Description: Imine Reductase from Aspergillus terreus in complex with NADPH4 and dibenz[c,e]azepine
[[Category: Unreleased Structures]]
[[Category: Sharma, M]]
[[Category: Grogan, G]]