5ooo - Revision history

OCA at 16:56, 13 December 2023

OCA — Wed, 13 Dec 2023 16:56:31 GMT

←Older revision		Revision as of 16:56, 13 December 2023
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	<StructureSection load='5ooo' size='340' side='right'caption='[[5ooo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5ooo' size='340' side='right'caption='[[5ooo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ooo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5OOO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ooo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rift_Valley_fever_virus Rift Valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OOO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ooo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ooo OCA], [~~http~~://pdbe.org/5ooo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ooo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ooo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ooo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ooo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ooo OCA], [https://pdbe.org/5ooo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ooo RCSB], [https://www.ebi.ac.uk/pdbsum/5ooo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ooo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NSS_RVFVZ NSS_RVFVZ] Inhibits host general transcription by inhibiting host basal transcription factor TFIIH.<ref>PMID:21543505</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Barski, M S~~]]	+	[[Category: Rift Valley fever virus]]
-	[[Category: ~~Potter, J A~~]]	+	[[Category: Barski MS]]
-	[[Category: ~~Schwarz-Linek, U~~]]	+	[[Category: Potter JA]]
-	[[Category: ~~Interferon antagonist]]~~	+	[[Category: Schwarz-Linek U]]
-	~~[[Category: Non~~-~~structural protein]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virulence factor~~]]	+

OCA at 07:30, 2 September 2020

OCA — Wed, 02 Sep 2020 07:30:05 GMT

←Older revision		Revision as of 07:30, 2 September 2020
Line 1:		Line 1:

	==Structure of the Rift Valley fever virus NSs protein core domain==		==Structure of the Rift Valley fever virus NSs protein core domain==
-	<StructureSection load='5ooo' size='340' side='right' caption='[[5ooo]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5ooo' size='340' side='right'caption='[[5ooo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ooo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OOO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ooo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OOO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ooo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ooo OCA], [http://pdbe.org/5ooo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ooo RCSB], [http://www.ebi.ac.uk/pdbsum/5ooo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ooo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ooo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ooo OCA], [http://pdbe.org/5ooo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ooo RCSB], [http://www.ebi.ac.uk/pdbsum/5ooo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ooo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Barski, M S]]		[[Category: Barski, M S]]
	[[Category: Potter, J A]]		[[Category: Potter, J A]]

OCA: Protected "5ooo" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 09:13:31 GMT

Protected "5ooo" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:13, 27 September 2017

OCA: New page: ==Structure of the Rift Valley fever virus NSs protein core domain==
OCA — Wed, 27 Sep 2017 09:13:29 GMT

New page: ==Structure of the Rift Valley fever virus NSs protein core domain== <StructureSection load='5ooo' size='340' side='right' caption='5ooo, resolution 2.20Å' scene=...

New page

==Structure of the Rift Valley fever virus NSs protein core domain==
<StructureSection load='5ooo' size='340' side='right' caption='[[5ooo]], [[Resolution|resolution]] 2.20Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ooo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OOO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ooo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ooo OCA], [http://pdbe.org/5ooo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ooo RCSB], [http://www.ebi.ac.uk/pdbsum/5ooo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ooo ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Rift Valley fever phlebovirus (RVFV) is a clinically and economically important pathogen increasingly likely to cause widespread epidemics. RVFV virulence depends on the interferon antagonist non-structural protein (NSs), which remains poorly characterized. We identified a stable core domain of RVFV NSs (residues 83-248), and solved its crystal structure, a novel all-helical fold organized into highly ordered fibrils. A hallmark of RVFV pathology is NSs filament formation in infected cell nuclei. Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting it contains all essential determinants for nuclear translocation and filament formation. Mutations of key crystal fibril interface residues in viruses encoding full-length NSs completely abrogated intranuclear filament formation in infected cells. We propose the fibrillar arrangement of the NSs core domain in crystals reveals the molecular basis of assembly of this key virulence factor in cell nuclei. Our findings have important implications for fundamental understanding of RVFV virulence.

Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments.,Barski M, Brennan B, Miller OK, Potter JA, Vijayakrishnan S, Bhella D, Naismith JH, Elliott RM, Schwarz-Linek U Elife. 2017 Sep 15;6. pii: e29236. doi: 10.7554/eLife.29236. PMID:28915104<ref>PMID:28915104</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ooo" style="background-color:#fffaf0;"></div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Barski, M S]]
[[Category: Potter, J A]]
[[Category: Schwarz-Linek, U]]
[[Category: Interferon antagonist]]
[[Category: Non-structural protein]]
[[Category: Viral protein]]
[[Category: Virulence factor]]