5oqr - Revision history

OCA at 16:58, 13 December 2023

OCA — Wed, 13 Dec 2023 16:58:25 GMT

←Older revision		Revision as of 16:58, 13 December 2023
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	<StructureSection load='5oqr' size='340' side='right'caption='[[5oqr]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='5oqr' size='340' side='right'caption='[[5oqr]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oqr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OQR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5OQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oqr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OQR FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5oqn\|5oqn]]~~, [[~~5oqo~~\|~~5oqo]], [[5oqp\|5oqp]], [[5oqq\|5oqq~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.61Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5oqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oqr OCA], [~~http~~://pdbe.org/5oqr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5oqr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5oqr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5oqr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oqr OCA], [https://pdbe.org/5oqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oqr RCSB], [https://www.ebi.ac.uk/pdbsum/5oqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CND3_SCHPO CND3_SCHPO]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.<ref>PMID:10485849</ref> [[http://www.uniprot.org/uniprot/CND2_SCHPO CND2_SCHPO]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase in processes such as DNA repair.<ref>PMID:10485849</ref> <ref>PMID:12000964</ref>	+	[https://www.uniprot.org/uniprot/CND3_SCHPO CND3_SCHPO] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.<ref>PMID:10485849</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Haering, C H~~]]	+	[[Category: Schizosaccharomyces pombe 972h-]]
-	[[Category: ~~Hassler, M~~]]	+	[[Category: Haering CH]]
-	[[Category: ~~Kschonsak,~~ M]]	+	[[Category: Hassler M]]
-	[[Category: ~~Cell cycle]]~~	+	[[Category: Kschonsak M]]
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Heat repeat]]~~	+
-	~~[[Category: Kleisin]]~~	+
-	~~[[Category: Smc complex~~]]	+

OCA at 07:30, 2 September 2020

OCA — Wed, 02 Sep 2020 07:30:41 GMT

←Older revision		Revision as of 07:30, 2 September 2020
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	==Crystal structure of the S. pombe condensin Cnd3-Cnd2 subcomplex==		==Crystal structure of the S. pombe condensin Cnd3-Cnd2 subcomplex==
-	<StructureSection load='5oqr' size='340' side='right' caption='[[5oqr]], [[Resolution\|resolution]] 2.61Å' scene=''>	+	<StructureSection load='5oqr' size='340' side='right'caption='[[5oqr]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oqr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OQR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oqr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OQR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OQR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5oqn\|5oqn]], [[5oqo\|5oqo]], [[5oqp\|5oqp]], [[5oqq\|5oqq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5oqn\|5oqn]], [[5oqo\|5oqo]], [[5oqp\|5oqp]], [[5oqq\|5oqq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5oqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oqr OCA], [http://pdbe.org/5oqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oqr RCSB], [http://www.ebi.ac.uk/pdbsum/5oqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oqr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5oqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oqr OCA], [http://pdbe.org/5oqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oqr RCSB], [http://www.ebi.ac.uk/pdbsum/5oqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5oqr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5oqr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Condensin\|Condensin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Haering, C H]]		[[Category: Haering, C H]]
	[[Category: Hassler, M]]		[[Category: Hassler, M]]

OCA at 07:08, 18 October 2017

OCA — Wed, 18 Oct 2017 07:08:23 GMT

←Older revision		Revision as of 07:08, 18 October 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5oqr is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of the S. pombe condensin Cnd3-Cnd2 subcomplex==
		+	<StructureSection load='5oqr' size='340' side='right' caption='[[5oqr]], [[Resolution\|resolution]] 2.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5oqr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OQR FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5oqn\|5oqn]], [[5oqo\|5oqo]], [[5oqp\|5oqp]], [[5oqq\|5oqq]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oqr OCA], [http://pdbe.org/5oqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oqr RCSB], [http://www.ebi.ac.uk/pdbsum/5oqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oqr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CND3_SCHPO CND3_SCHPO]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.<ref>PMID:10485849</ref> [[http://www.uniprot.org/uniprot/CND2_SCHPO CND2_SCHPO]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase in processes such as DNA repair.<ref>PMID:10485849</ref> <ref>PMID:12000964</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby ensure the successful segregation of replicated genomes. Insights into how condensin complexes bind to chromosomes and alter their topology are essential for understanding the molecular principles behind the large-scale chromatin rearrangements that take place during cell divisions. Here, we identify a direct DNA-binding site in the eukaryotic condensin complex, which is formed by its Ycg1Cnd3 HEAT-repeat and Brn1Cnd2 kleisin subunits. DNA co-crystal structures reveal a conserved, positively charged groove that accommodates the DNA double helix. A peptide loop of the kleisin subunit encircles the bound DNA and, like a safety belt, prevents its dissociation. Firm closure of the kleisin loop around DNA is essential for the association of condensin complexes with chromosomes and their DNA-stimulated ATPase activity. Our data suggest a sophisticated molecular basis for anchoring condensin complexes to chromosomes that enables the formation of large-sized chromatin loops.

-	~~Authors: Kschonsak~~, M., ~~Hassler~~, M., Haering~~, C~~.H.	+	Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.,Kschonsak M, Merkel F, Bisht S, Metz J, Rybin V, Hassler M, Haering CH Cell. 2017 Oct 4. pii: S0092-8674(17)31057-7. doi: 10.1016/j.cell.2017.09.008. PMID:28988770<ref>PMID:28988770</ref>

-	~~Description: Crystal structure~~ of the S. ~~pombe condensin Cnd3-Cnd2 subcomplex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Kschonsak~~, M]]	+	<div class="pdbe-citations 5oqr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Haering, C H]]
	[[Category: Hassler, M]]		[[Category: Hassler, M]]
-	[[Category: ~~Haering~~, ~~C.H~~]]	+	[[Category: Kschonsak, M]]
		+	[[Category: Cell cycle]]
		+	[[Category: Dna-binding]]
		+	[[Category: Heat repeat]]
		+	[[Category: Kleisin]]
		+	[[Category: Smc complex]]

OCA: Protected "5oqr" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 12:44:00 GMT

Protected "5oqr" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:44, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5oqr is ON HOLD until Paper Publication Authors: Kschonsak, M., Hassler, M., Haering, C.H. Description: Crystal structure of the S. pombe condensin...

OCA — Wed, 27 Sep 2017 12:43:59 GMT

New page: '''Unreleased structure''' The entry 5oqr is ON HOLD until Paper Publication Authors: Kschonsak, M., Hassler, M., Haering, C.H. Description: Crystal structure of the S. pombe condensin...

New page

'''Unreleased structure'''

The entry 5oqr is ON HOLD until Paper Publication

Authors: Kschonsak, M., Hassler, M., Haering, C.H.

Description: Crystal structure of the S. pombe condensin Cnd3-Cnd2 subcomplex
[[Category: Unreleased Structures]]
[[Category: Kschonsak, M]]
[[Category: Hassler, M]]
[[Category: Haering, C.H]]