5oxp - Revision history

OCA at 01:27, 28 December 2023

OCA — Thu, 28 Dec 2023 01:27:52 GMT

←Older revision		Revision as of 01:27, 28 December 2023
Line 1:		Line 1:

	==PepTSt in occluded conformation with phosphate ion bound==		==PepTSt in occluded conformation with phosphate ion bound==
-	<StructureSection load='5oxp' size='340' side='right' caption='[[5oxp]], [[Resolution\|resolution]] 2.37Å' scene=''>	+	<StructureSection load='5oxp' size='340' side='right'caption='[[5oxp]], [[Resolution\|resolution]] 2.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oxp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strt2 Strt2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OXP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus_LMG_18311 Streptococcus thermophilus LMG 18311]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OXP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=78M:(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78M</scene>, <scene name='pdbligand=78N:(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78N</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.372Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dtpT, stu0970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264199 STRT2])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=78M:(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78M</scene>, <scene name='pdbligand=78N:(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78N</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5oxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oxp OCA], [~~http~~://pdbe.org/5oxp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5oxp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5oxp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5oxp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oxp OCA], [https://pdbe.org/5oxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oxp RCSB], [https://www.ebi.ac.uk/pdbsum/5oxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oxp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5M4H8_STRT2 Q5M4H8_STRT2]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5oxp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5oxp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Strt2~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Loew, C~~]]	+	[[Category: Streptococcus thermophilus LMG 18311]]
-	[[Category: ~~Molledo, M Martinez~~]]	+	[[Category: Loew C]]
-	[[Category: ~~Quistgaard, E~~ M]]	+	[[Category: Martinez Molledo M]]
-	[[Category: ~~Alpha-helical membrane protein]]~~	+	[[Category: Quistgaard EM]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Mfs fold]]~~	+
-	~~[[Category: Peptide transporter]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:29, 18 April 2018

OCA — Wed, 18 Apr 2018 06:29:53 GMT

←Older revision		Revision as of 06:29, 18 April 2018
Line 3:		Line 3:
	<StructureSection load='5oxp' size='340' side='right' caption='[[5oxp]], [[Resolution\|resolution]] 2.37Å' scene=''>		<StructureSection load='5oxp' size='340' side='right' caption='[[5oxp]], [[Resolution\|resolution]] 2.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oxp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OXP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oxp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strt2 Strt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OXP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=78M:(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78M</scene>, <scene name='pdbligand=78N:(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78N</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=78M:(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78M</scene>, <scene name='pdbligand=78N:(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78N</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dtpT, stu0970 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264199 STRT2])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oxp OCA], [http://pdbe.org/5oxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oxp RCSB], [http://www.ebi.ac.uk/pdbsum/5oxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oxp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oxp OCA], [http://pdbe.org/5oxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oxp RCSB], [http://www.ebi.ac.uk/pdbsum/5oxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oxp ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proton-dependent oligopeptide transporters (POTs) are important for uptake of dietary di- and tripeptides in many organisms, and in humans are also involved in drug absorption. These transporters accept a wide range of substrates, but the structural basis for how different peptide side chains are accommodated has so far remained obscure. Twenty-eight peptides were screened for binding to PepTSt from Streptococcus thermophilus, and structures were determined of PepTSt in complex with four physicochemically diverse dipeptides, which bind with millimolar affinity: Ala-Leu, Phe-Ala, Ala-Gln, and Asp-Glu. The structures show that PepTSt can adapt to different peptide side chains through movement of binding site residues and water molecules, and that a good fit can be further aided by adjustment of the position of the peptide itself. Finally, structures were also determined in complex with adventitiously bound HEPES, polyethylene glycol, and phosphate molecules, which further underline the adaptability of the binding site.
		+
		+	Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter.,Martinez Molledo M, Quistgaard EM, Flayhan A, Pieprzyk J, Low C Structure. 2018 Mar 6;26(3):467-476.e4. doi: 10.1016/j.str.2018.01.005. Epub 2018, Feb 8. PMID:29429879<ref>PMID:29429879</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5oxp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Strt2]]
	[[Category: Loew, C]]		[[Category: Loew, C]]
	[[Category: Molledo, M Martinez]]		[[Category: Molledo, M Martinez]]

OCA at 07:13, 22 February 2018

OCA — Thu, 22 Feb 2018 07:13:20 GMT

←Older revision		Revision as of 07:13, 22 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5oxp ~~is ON HOLD until Paper Publication~~	+	==PepTSt in occluded conformation with phosphate ion bound==
-		+	<StructureSection load='5oxp' size='340' side='right' caption='[[5oxp]], [[Resolution\|resolution]] 2.37Å' scene=''>
-	~~Authors~~: ~~Martinez Molledo, M~~.~~, Quistgaard, E~~.M.~~, Loew, C~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5oxp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OXP FirstGlance]. <br>
-	~~Description~~: ~~PepTSt in occluded conformation with phosphate ion bound~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=78M:(2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78M</scene>, <scene name='pdbligand=78N:(2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE'>78N</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oxp OCA], [http://pdbe.org/5oxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oxp RCSB], [http://www.ebi.ac.uk/pdbsum/5oxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oxp ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Martinez Molledo~~, M]]	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Loew, C]]		[[Category: Loew, C]]
-	[[Category: Quistgaard, E.M]]	+	[[Category: Molledo, M Martinez]]
		+	[[Category: Quistgaard, E M]]
		+	[[Category: Alpha-helical membrane protein]]
		+	[[Category: Membrane protein]]
		+	[[Category: Mfs fold]]
		+	[[Category: Peptide transporter]]
		+	[[Category: Transport protein]]

OCA at 07:58, 4 October 2017

OCA — Wed, 04 Oct 2017 07:58:42 GMT

←Older revision		Revision as of 07:58, 4 October 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5oxp is ON HOLD	+	The entry 5oxp is ON HOLD until Paper Publication

	Authors: Martinez Molledo, M., Quistgaard, E.M., Loew, C.		Authors: Martinez Molledo, M., Quistgaard, E.M., Loew, C.
Line 7:		Line 7:
	Description: PepTSt in occluded conformation with phosphate ion bound		Description: PepTSt in occluded conformation with phosphate ion bound
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Martinez Molledo, M]]
	[[Category: Loew, C]]		[[Category: Loew, C]]
	[[Category: Quistgaard, E.M]]		[[Category: Quistgaard, E.M]]
-	[[Category: Martinez Molledo, M]]

OCA: Protected "5oxp" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 12:58:35 GMT

Protected "5oxp" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:58, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5oxp is ON HOLD Authors: Martinez Molledo, M., Quistgaard, E.M., Loew, C. Description: PepTSt in occluded conformation with phosphate ion bound [[C...

OCA — Wed, 27 Sep 2017 12:58:34 GMT

New page: '''Unreleased structure''' The entry 5oxp is ON HOLD Authors: Martinez Molledo, M., Quistgaard, E.M., Loew, C. Description: PepTSt in occluded conformation with phosphate ion bound [[C...

New page

'''Unreleased structure'''

The entry 5oxp is ON HOLD

Authors: Martinez Molledo, M., Quistgaard, E.M., Loew, C.

Description: PepTSt in occluded conformation with phosphate ion bound
[[Category: Unreleased Structures]]
[[Category: Loew, C]]
[[Category: Quistgaard, E.M]]
[[Category: Martinez Molledo, M]]