5pnt - Revision history

OCA at 09:50, 22 May 2024

OCA — Wed, 22 May 2024 09:50:43 GMT

←Older revision		Revision as of 09:50, 22 May 2024
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 5pnt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5pnt" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:52, 9 August 2023

OCA — Wed, 09 Aug 2023 06:52:01 GMT

←Older revision		Revision as of 06:52, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='5pnt' size='340' side='right'caption='[[5pnt]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5pnt' size='340' side='right'caption='[[5pnt]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5PNT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PNT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MES:~~2~~-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [~~http~~://pdbe.org/5pnt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5pnt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5pnt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [https://pdbe.org/5pnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [https://www.ebi.ac.uk/pdbsum/5pnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pnt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.	+	[https://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acid phosphatase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin, D]]	+	[[Category: Lin D]]
-	[[Category: Stauffacher, C]]	+	[[Category: Stauffacher C]]
-	[[Category: Vanetten, R]]	+	[[Category: Vanetten R]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Tyrosine phosphatase~~]]	+

OCA at 07:47, 2 September 2020

OCA — Wed, 02 Sep 2020 07:47:31 GMT

←Older revision		Revision as of 07:47, 2 September 2020
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY==		==CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY==
-	<StructureSection load='5pnt' size='340' side='right' caption='[[5pnt]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5pnt' size='340' side='right'caption='[[5pnt]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5PNT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5PNT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://pdbe.org/5pnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://pdbe.org/5pnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pnt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/5pnt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/5pnt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 5pnt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5pnt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 38:
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lin, D]]		[[Category: Lin, D]]
	[[Category: Stauffacher, C]]		[[Category: Stauffacher, C]]
	[[Category: Vanetten, R]]		[[Category: Vanetten, R]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
		+	[[Category: Acetylation]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Tyrosine phosphatase]]		[[Category: Tyrosine phosphatase]]

OCA at 08:18, 8 February 2016

OCA — Mon, 08 Feb 2016 08:18:26 GMT

←Older revision		Revision as of 08:18, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='5pnt' size='340' side='right' caption='[[5pnt]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5pnt' size='340' side='right' caption='[[5pnt]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PNT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PNT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://pdbe.org/5pnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5pnt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5pnt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Lin, D]]		[[Category: Lin, D]]
	[[Category: Stauffacher, C]]		[[Category: Stauffacher, C]]

OCA at 21:55, 24 December 2014

OCA — Wed, 24 Dec 2014 21:55:16 GMT

←Older revision		Revision as of 21:55, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PNT FirstGlance]. <br>		<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PNT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Lin, D.]]	+	[[Category: Lin, D]]
-	[[Category: Stauffacher, C.]]	+	[[Category: Stauffacher, C]]
-	[[Category: Vanetten, R.]]	+	[[Category: Vanetten, R]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Tyrosine phosphatase]]		[[Category: Tyrosine phosphatase]]

OCA: Protected "5pnt" [edit=sysop:move=sysop]

OCA — Thu, 05 Jun 2014 08:18:00 GMT

Protected "5pnt" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:18, 5 June 2014

OCA at 08:17, 5 June 2014

OCA — Thu, 05 Jun 2014 08:17:59 GMT

←Older revision		Revision as of 08:17, 5 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY==
-	[[~~Image~~:5pnt.~~png\|left~~\|200px]]	+	<StructureSection load='5pnt' size='340' side='right' caption='[[5pnt]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5pnt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PNT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/5pnt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The low molecular weight phosphotyrosine phosphatases (PTPases) constitute a distinctive class of phosphotyrosine phosphatases that is widely distributed among vertebrate and invertebrate organisms. In vertebrates, two isoenzymes of these low molecular weight PTPases are commonly expressed. The two human isoenzymes, HCPTPA and HCPTPB, differ in an alternatively spliced sequence (residues 40-73) referred to as the variable loop, resulting in isoenzymes that have different substrate specificities and inhibitor/activator responses. We present here the x-ray crystallographic structure of a human low molecular weight PTPase solved by molecular replacement to 2.2 A. The structure of human low molecular weight PTPase is compared with a structure representing the other isoenzyme in this PTPase class, in each case with a sulfonate inhibitor bound to the active site. Possible aromatic residue interactions with the phosphotyrosine substrate are proposed from an examination of the binding site of the inhibitors. Differences are observed in the variable loop region, which forms one wall and the floor of a long crevice leading from the active-site loop. A set of residues lying along this crevice (amino acids 49, 50, and 53) is suggested to be responsible for differences in substrate specificity in these two enzymes.

-	~~<!--~~	+	Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity.,Zhang M, Stauffacher CV, Lin D, Van Etten RL J Biol Chem. 1998 Aug 21;273(34):21714-20. PMID:9705307<ref>PMID:9705307</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_5pnt"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_5pnt\| PDB=5pnt \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_9705307}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 9705307 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_9705307}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~5PNT is a 1 chain structure of sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:9705307<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 30:		Line 35:
	[[Category: Vanetten, R.]]		[[Category: Vanetten, R.]]
	[[Category: Zhang, M.]]		[[Category: Zhang, M.]]
-	[[Category: Acetylation]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Tyrosine phosphatase]]		[[Category: Tyrosine phosphatase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:31:00 2009''

OCA at 18:31, 16 February 2009

OCA — Mon, 16 Feb 2009 18:31:01 GMT

←Older revision		Revision as of 18:31, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	5PNT is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA].	+	5PNT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PNT OCA].

	==Reference==		==Reference==
-	Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity., Zhang M, Stauffacher CV, Lin D, Van Etten RL, J Biol Chem. 1998 Aug 21;273(34):21714-20. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9705307 9705307]~~	+	<ref group="xtra">PMID:9705307</ref><references group="xtra"/>
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Lin, D.]]		[[Category: Lin, D.]]
	[[Category: Stauffacher, C.]]		[[Category: Stauffacher, C.]]
Line 35:		Line 34:
	[[Category: Tyrosine phosphatase]]		[[Category: Tyrosine phosphatase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 14~~:08:~~54 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:31:00 2009''

OCA at 11:08, 3 July 2008

OCA — Thu, 03 Jul 2008 11:08:55 GMT

←Older revision		Revision as of 11:08, 3 July 2008
Line 1:		Line 1:
-	[[Image:5pnt.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:5pnt.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_5pnt\| PDB=5pnt \| SCENE= }}		{{STRUCTURE_5pnt\| PDB=5pnt \| SCENE= }}

-	~~'''~~CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY~~'''~~	+	===CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY===


-	~~==Overview==~~	+	<!--
-	The low molecular weight phosphotyrosine phosphatases (PTPases) constitute a distinctive class of phosphotyrosine phosphatases that is widely distributed among vertebrate and invertebrate organisms. In vertebrates, ~~two isoenzymes of these low molecular weight PTPases are commonly expressed. The two human isoenzymes~~, ~~HCPTPA and HCPTPB, differ in an alternatively spliced sequence~~ (~~residues 40-73) referred to~~ as ~~the variable loop, resulting in isoenzymes that have different substrate specificities and inhibitor~~/~~activator responses~~. ~~We present here the x-ray crystallographic structure of a human low molecular weight PTPase solved by molecular replacement to 2~~.~~2 A. The structure of human low molecular weight PTPase~~ is ~~compared with a structure representing~~ the ~~other isoenzyme in this PTPase class, in each case with a sulfonate inhibitor bound to the active site~~. Possible aromatic residue interactions with the phosphotyrosine substrate are proposed from an examination of the binding site of the inhibitors. Differences are observed in the variable loop region, which forms one wall and the floor of a long crevice leading from the active-~~site loop. A set of residues lying along this crevice (amino acids 49, 50, and 53) is suggested to be responsible for differences in substrate specificity in these two enzymes.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_9705307}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9705307 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_9705307}}

	==About this Structure==		==About this Structure==
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Tyrosine phosphatase]]		[[Category: Tyrosine phosphatase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:37:01 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:08:54 2008''

OCA at 19:37, 4 May 2008

OCA — Sun, 04 May 2008 19:37:01 GMT

←Older revision		Revision as of 19:37, 4 May 2008
Line 1:		Line 1:
	[[Image:5pnt.gif\|left\|200px]]		[[Image:5pnt.gif\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 5pnt \|SIZE=350\|CAPTION= <scene name='initialview01'>5pnt</scene>~~, ~~resolution 2~~.~~2Å~~	+	The line below this paragraph, containing "STRUCTURE_5pnt", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <~~scene ~~name='pdbligand=MES:2-(N-MORPHOLINO~~)~~-ETHANESULFONIC+ACID'>MES</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY= <span class='plainlinks'>[http://en~~.~~wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span~~>	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	\|~~DOMAIN~~=	+	{{STRUCTURE_5pnt\| PDB=5pnt \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pnt OCA], [http://www.ebi.ac.uk/pdbsum/5pnt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5pnt RCSB]</span>	+
-	}}	+

	'''CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY'''		'''CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY'''
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	[[Category: Vanetten, R.]]		[[Category: Vanetten, R.]]
	[[Category: Zhang, M.]]		[[Category: Zhang, M.]]
-	[[Category: ~~acetylation~~]]	+	[[Category: Acetylation]]
-	[[Category: ~~hydrolase~~]]	+	[[Category: Hydrolase]]
-	[[Category: ~~tyrosine~~ phosphatase]]	+	[[Category: Tyrosine phosphatase]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:37:01 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:42:03 2008''	+