5qcg - Revision history

OCA at 14:10, 1 February 2024

OCA — Thu, 01 Feb 2024 14:10:42 GMT

←Older revision		Revision as of 14:10, 1 February 2024
Line 1:		Line 1:

	==Crystal structure of human Cathepsin-S with bound ligand==		==Crystal structure of human Cathepsin-S with bound ligand==
-	<StructureSection load='5qcg' size='340' side='right'caption='[[5qcg]]' scene=''>	+	<StructureSection load='5qcg' size='340' side='right'caption='[[5qcg]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qcg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QCG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcg OCA], [https://pdbe.org/5qcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qcg RCSB], [https://www.ebi.ac.uk/pdbsum/5qcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJJ:N-benzyl-1-{2-chloro-5-[2-(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethyl]phenyl}methanamine'>BJJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcg OCA], [https://pdbe.org/5qcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qcg RCSB], [https://www.ebi.ac.uk/pdbsum/5qcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

	==See Also==		==See Also==
Line 11:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ameriks MK]]		[[Category: Ameriks MK]]

OCA at 14:06, 17 November 2021

OCA — Wed, 17 Nov 2021 14:06:13 GMT

←Older revision		Revision as of 14:06, 17 November 2021
Line 1:		Line 1:

	==Crystal structure of human Cathepsin-S with bound ligand==		==Crystal structure of human Cathepsin-S with bound ligand==
-	<StructureSection load='5qcg' size='340' side='right' caption='[[5qcg]]~~, [[Resolution\|resolution]] 2.70Å~~' scene=''>	+	<StructureSection load='5qcg' size='340' side='right'caption='[[5qcg]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[5qcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QCG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BJJ:N-benzyl-1-{2-chloro-5-[2-(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethyl]phenyl}methanamine'>BJJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcg OCA], [https://pdbe.org/5qcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qcg RCSB], [https://www.ebi.ac.uk/pdbsum/5qcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcg ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcg OCA], [~~http~~://pdbe.org/5qcg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qcg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qcg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcg ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

	==See Also==		==See Also==
-	*[[Cathepsin\|Cathepsin]]	+	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cathepsin S]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Human~~]]	+	[[Category: Ameriks MK]]
-	[[Category: Ameriks~~, M K~~]]	+	[[Category: Bembenek SD]]
-	[[Category: Bembenek~~, S D~~]]	+	[[Category: Burley SK]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Mirzadegan T]]
-	[[Category: Mirzadegan, T]]	+	[[Category: Shao C]]
-	[[Category: Shao, C]]	+	[[Category: Yang H]]
-	[[Category: Yang, H]]	+
-	~~[[Category: Cathepsin s]]~~	+
-	~~[[Category: D3r]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ligand docking~~]]	+

OCA at 06:13, 6 June 2018

OCA — Wed, 06 Jun 2018 06:13:41 GMT

←Older revision		Revision as of 06:13, 6 June 2018
Line 1:		Line 1:

	==Crystal structure of human Cathepsin-S with bound ligand==		==Crystal structure of human Cathepsin-S with bound ligand==
-	<StructureSection load='5qcg' size='340' side='right' caption='[[5qcg]], [[Resolution\|resolution]] 2.69Å' scene=''>	+	<StructureSection load='5qcg' size='340' side='right' caption='[[5qcg]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5qcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5qcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCG FirstGlance]. <br>
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.		[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
		+
		+	==See Also==
		+	*[[Cathepsin\|Cathepsin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:19, 22 February 2018

OCA — Thu, 22 Feb 2018 08:19:58 GMT

←Older revision		Revision as of 08:19, 22 February 2018
Line 3:		Line 3:
	<StructureSection load='5qcg' size='340' side='right' caption='[[5qcg]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='5qcg' size='340' side='right' caption='[[5qcg]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qcg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BJJ:N-benzyl-1-{2-chloro-5-[2-(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethyl]phenyl}methanamine'>BJJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BJJ:N-benzyl-1-{2-chloro-5-[2-(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethyl]phenyl}methanamine'>BJJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcg OCA], [http://pdbe.org/5qcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qcg RCSB], [http://www.ebi.ac.uk/pdbsum/5qcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcg OCA], [http://pdbe.org/5qcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qcg RCSB], [http://www.ebi.ac.uk/pdbsum/5qcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcg ProSAT]</span></td></tr>
Line 13:		Line 14:
	</StructureSection>		</StructureSection>
	[[Category: Cathepsin S]]		[[Category: Cathepsin S]]
		+	[[Category: Human]]
	[[Category: Ameriks, M K]]		[[Category: Ameriks, M K]]
	[[Category: Bembenek, S D]]		[[Category: Bembenek, S D]]

OCA at 06:15, 20 December 2017

OCA — Wed, 20 Dec 2017 06:15:04 GMT

←Older revision		Revision as of 06:15, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qcg is ~~ON HOLD~~	+	==Crystal structure of human Cathepsin-S with bound ligand==
-		+	<StructureSection load='5qcg' size='340' side='right' caption='[[5qcg]], [[Resolution\|resolution]] 2.69Å' scene=''>
-	~~Authors~~: ~~Yang~~, H., ~~Shao~~, C., ~~Burley~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qcg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCG FirstGlance]. <br>
-	~~Description~~: ~~Ligand binding~~ to Cathepsin S	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BJJ:N-benzyl-1-{2-chloro-5-[2-(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethyl]phenyl}methanamine'>BJJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
-	[[Category: Burley, S]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcg OCA], [http://pdbe.org/5qcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qcg RCSB], [http://www.ebi.ac.uk/pdbsum/5qcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cathepsin S]]
		+	[[Category: Ameriks, M K]]
		+	[[Category: Bembenek, S D]]
		+	[[Category: Burley, S K]]
		+	[[Category: Mirzadegan, T]]
		+	[[Category: Shao, C]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
-	[[Category: ~~Shao, C~~]]	+	[[Category: Cathepsin s]]
		+	[[Category: D3r]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ligand docking]]

OCA: Protected "5qcg" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 13:20:03 GMT

Protected "5qcg" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:20, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5qcg is ON HOLD Authors: Yang, H., Shao, C., Burley, S. Description: Ligand binding to Cathepsin S Category: Unreleased Structures [[Category: ...

OCA — Wed, 27 Sep 2017 13:20:02 GMT

New page: '''Unreleased structure''' The entry 5qcg is ON HOLD Authors: Yang, H., Shao, C., Burley, S. Description: Ligand binding to Cathepsin S Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 5qcg is ON HOLD

Authors: Yang, H., Shao, C., Burley, S.

Description: Ligand binding to Cathepsin S
[[Category: Unreleased Structures]]
[[Category: Burley, S]]
[[Category: Yang, H]]
[[Category: Shao, C]]