5qgh - Revision history

OCA at 09:53, 15 November 2023

OCA — Wed, 15 Nov 2023 09:53:56 GMT

←Older revision		Revision as of 09:53, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='5qgh' size='340' side='right'caption='[[5qgh]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='5qgh' size='340' side='right'caption='[[5qgh]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qgh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QGH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QGH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H2D:(2R)-N-(1,2-oxazol-3-yl)-2-phenylbutanamide'>H2D~~</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO~~</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H2D:(2R)-N-(1,2-oxazol-3-yl)-2-phenylbutanamide'>H2D</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qgh OCA], [~~http~~://pdbe.org/5qgh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qgh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qgh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qgh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qgh OCA], [https://pdbe.org/5qgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qgh RCSB], [https://www.ebi.ac.uk/pdbsum/5qgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qgh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN]] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).	+	[https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aimon, A]]	+	[[Category: Aimon A]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Bradley~~, A R~~]]	+	[[Category: Bradley AR]]
-	[[Category: Brandao-Neto, J]]	+	[[Category: Brandao-Neto J]]
-	[[Category: Brennan~~, P E~~]]	+	[[Category: Brennan PE]]
-	[[Category: Collins, P]]	+	[[Category: Collins P]]
-	[[Category: ~~Delft, F von~~]]	+	[[Category: Diaz Saez L]]
-	[[Category: Douangamath, A]]	+	[[Category: Douangamath A]]
-	[[Category: Edwards, A]]	+	[[Category: Edwards A]]
-	[[Category: Elkins, J]]	+	[[Category: Elkins J]]
-	[[Category: Fairhead, M]]	+	[[Category: Fairhead M]]
-	[[Category: Huber, K]]	+	[[Category: Huber K]]
-	[[Category: Krojer, T]]	+	[[Category: Krojer T]]
-	[[Category: London, N]]	+	[[Category: London N]]
-	[[Category: Nelson, A]]	+	[[Category: Nelson A]]
-	[[Category: Ruda~~, G F]]~~	+	[[Category: Ruda GF]]
-	~~[[Category: Saez, L Diaz~~]]	+	[[Category: Spencer J]]
-	[[Category: Spencer, J]]	+	[[Category: Srikannathasan V]]
-	[[Category: Srikannathasan, V]]	+	[[Category: Szommer T]]
-	[[Category: Szommer, T]]	+	[[Category: Talon R]]
-	[[Category: Talon, R]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Hydrolase]]~~	+
-	~~[[Category: Nudix domain]]~~	+
-	~~[[Category: Pandda]]~~	+
-	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~	+
-	~~[[Category: Xchemexplorer~~]]	+

OCA at 06:26, 27 March 2019

OCA — Wed, 27 Mar 2019 06:26:14 GMT

←Older revision		Revision as of 06:26, 27 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qgh ~~is ON HOLD~~	+	==PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with FMOPL000420a==
-		+	<StructureSection load='5qgh' size='340' side='right'caption='[[5qgh]], [[Resolution\|resolution]] 1.82Å' scene=''>
-	~~Authors~~: ~~Krojer, T~~.~~, Talon, R~~.~~, Fairhead, M~~.~~, Diaz Saez, L~~.~~, Bradley, A~~.R.~~, Aimon, A~~.~~, Collins, P., Brandao~~-~~Neto, J~~., ~~Douangamath~~, A., ~~Ruda~~, G.F.~~, Szommer, T~~.~~, Srikannathasan, V~~., ~~Elkins, J~~.~~, Spencer, J~~.~~, London, N~~., ~~Nelson, A~~., ~~Brennan, P~~.E.~~, Huber, K~~., ~~Bountra, C~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.~~, von Delft, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qgh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QGH FirstGlance]. <br>
-	~~Description~~: ~~PanDDA analysis group deposition~~ of ~~models~~ with ~~modelled events (e~~.g. ~~bound ligands~~) --~~Crystal Structure of NUDT7~~ in ~~complex with FMOPL000420a~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H2D:(2R)-N-(1,2-oxazol-3-yl)-2-phenylbutanamide'>H2D</scene></td></tr>
-	~~[[Category: Unreleased Structures]]~~	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	[[Category: ~~Spencer, J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qgh OCA], [http://pdbe.org/5qgh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qgh RCSB], [http://www.ebi.ac.uk/pdbsum/5qgh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qgh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN]] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aimon, A]]		[[Category: Aimon, A]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Bradley, A R]]
		+	[[Category: Brandao-Neto, J]]
		+	[[Category: Brennan, P E]]
		+	[[Category: Collins, P]]
		+	[[Category: Delft, F von]]
		+	[[Category: Douangamath, A]]
		+	[[Category: Edwards, A]]
	[[Category: Elkins, J]]		[[Category: Elkins, J]]
-	[[Category: ~~Collins~~, P]]	+	[[Category: Fairhead, M]]
	[[Category: Huber, K]]		[[Category: Huber, K]]
-	[[Category: Ruda, G.F]]
-	[[Category: Arrowsmith, C.H]]
-	[[Category: Brandao-Neto, J]]
-	[[Category: Diaz Saez, L]]
-	[[Category: Fairhead, M]]
-	[[Category: Von Delft, F]]
-	[[Category: Bradley, A.R]]
-	[[Category: Talon, R]]
-	[[Category: Brennan, P.E]]
-	[[Category: Edwards, A]]
-	[[Category: Douangamath, A]]
-	[[Category: Szommer, T]]
	[[Category: Krojer, T]]		[[Category: Krojer, T]]
		+	[[Category: London, N]]
		+	[[Category: Nelson, A]]
		+	[[Category: Ruda, G F]]
		+	[[Category: Saez, L Diaz]]
		+	[[Category: Spencer, J]]
	[[Category: Srikannathasan, V]]		[[Category: Srikannathasan, V]]
-	[[Category: ~~Bountra~~, C]]	+	[[Category: Szommer, T]]
-	[[Category: ~~Nelson~~, A]]	+	[[Category: Talon, R]]
-	[[Category: ~~London, N~~]]	+	[[Category: Hydrolase]]
		+	[[Category: Nudix domain]]
		+	[[Category: Pandda]]
		+	[[Category: Sgc - diamond i04-1 fragment screening]]
		+	[[Category: Xchemexplorer]]

OCA at 05:01, 31 October 2018

OCA — Wed, 31 Oct 2018 05:01:53 GMT

←Older revision		Revision as of 05:01, 31 October 2018
Line 3:		Line 3:
	The entry 5qgh is ON HOLD		The entry 5qgh is ON HOLD

-	Authors: Krojer, T., Talon, R., Fairhead, M., Diaz Saez, L., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., Spencer, J., London, N., Nelson, A., Brennan, P.E., Huber, K., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.	+	Authors: Krojer, T., Talon, R., Fairhead, M., Diaz Saez, L., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., Ruda, G.F., Szommer, T., Srikannathasan, V., Elkins, J., Spencer, J., London, N., Nelson, A., Brennan, P.E., Huber, K., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

	Description: PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) --Crystal Structure of NUDT7 in complex with FMOPL000420a		Description: PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) --Crystal Structure of NUDT7 in complex with FMOPL000420a
Line 9:		Line 9:
	[[Category: Spencer, J]]		[[Category: Spencer, J]]
	[[Category: Aimon, A]]		[[Category: Aimon, A]]
		+	[[Category: Elkins, J]]
	[[Category: Collins, P]]		[[Category: Collins, P]]
	[[Category: Huber, K]]		[[Category: Huber, K]]
		+	[[Category: Ruda, G.F]]
	[[Category: Arrowsmith, C.H]]		[[Category: Arrowsmith, C.H]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]
Line 21:		Line 23:
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Douangamath, A]]		[[Category: Douangamath, A]]
		+	[[Category: Szommer, T]]
	[[Category: Krojer, T]]		[[Category: Krojer, T]]
		+	[[Category: Srikannathasan, V]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
	[[Category: Nelson, A]]		[[Category: Nelson, A]]
	[[Category: London, N]]		[[Category: London, N]]

OCA: Protected "5qgh" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2018 05:42:41 GMT

Protected "5qgh" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 5qgh is ON HOLD Authors: Krojer, T., Talon, R., Fairhead, M., Diaz Saez, L., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A...

OCA — Wed, 23 May 2018 05:42:39 GMT

New page: '''Unreleased structure''' The entry 5qgh is ON HOLD Authors: Krojer, T., Talon, R., Fairhead, M., Diaz Saez, L., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A...

New page

'''Unreleased structure'''

The entry 5qgh is ON HOLD

Authors: Krojer, T., Talon, R., Fairhead, M., Diaz Saez, L., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., Spencer, J., London, N., Nelson, A., Brennan, P.E., Huber, K., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

Description: PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) --Crystal Structure of NUDT7 in complex with FMOPL000420a
[[Category: Unreleased Structures]]
[[Category: Spencer, J]]
[[Category: Aimon, A]]
[[Category: Collins, P]]
[[Category: Huber, K]]
[[Category: Arrowsmith, C.H]]
[[Category: Brandao-Neto, J]]
[[Category: Diaz Saez, L]]
[[Category: Fairhead, M]]
[[Category: Von Delft, F]]
[[Category: Bradley, A.R]]
[[Category: Talon, R]]
[[Category: Brennan, P.E]]
[[Category: Edwards, A]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Bountra, C]]
[[Category: Nelson, A]]
[[Category: London, N]]