5qit - Revision history

OCA at 08:55, 7 February 2024

OCA — Wed, 07 Feb 2024 08:55:58 GMT

←Older revision		Revision as of 08:55, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='5qit' size='340' side='right'caption='[[5qit]], [[Resolution\|resolution]] 1.46Å' scene=''>		<StructureSection load='5qit' size='340' side='right'caption='[[5qit]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qit]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QIT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QIT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J5J:N-[(E)-(3-methylphenyl)methylidene]acetamide'>J5J</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.46Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J5J:N-[(E)-(3-methylphenyl)methylidene]acetamide'>J5J</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qit OCA], [~~http~~://pdbe.org/5qit PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qit RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qit PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qit ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qit OCA], [https://pdbe.org/5qit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qit RCSB], [https://www.ebi.ac.uk/pdbsum/5qit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qit ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>	+	[https://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>
		+
		+	==See Also==
		+	*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ubiquitinyl hydrolase 1]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Bradley AR]]
-	[[Category: Bradley~~, A R~~]]	+	[[Category: Brandao-Neto J]]
-	[[Category: Brandao-Neto, J]]	+	[[Category: Collins P]]
-	[[Category: Collins, P]]	+	[[Category: Douangamath A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Douangamath, A]]	+	[[Category: Krojer T]]
-	[[Category: Edwards, A]]	+	[[Category: London N]]
-	[[Category: Krojer, T]]	+	[[Category: Resnick E]]
-	[[Category: London, N]]	+	[[Category: Sethi R]]
-	[[Category: Resnick, E]]	+	[[Category: Talon R]]
-	[[Category: Sethi, R]]	+	[[Category: Von Delft F]]
-	[[Category: Talon, R]]	+
-	[[Category: ~~Deubiquitinating enzyme otub2]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Protease otub2]]~~	+
-	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~	+
-	~~[[Category: Xchemexplorer~~]]	+

OCA at 07:34, 18 December 2019

OCA — Wed, 18 Dec 2019 07:34:48 GMT

←Older revision		Revision as of 07:34, 18 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qit ~~is ON HOLD~~	+	==Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102821==
-		+	<StructureSection load='5qit' size='340' side='right'caption='[[5qit]], [[Resolution\|resolution]] 1.46Å' scene=''>
-	~~Authors~~: ~~Sethi, R~~.~~, Douangamath, A~~., ~~Resnick~~, E., ~~Bradley, A~~.R., ~~Collins, P~~.~~, Brandao~~-~~Neto, J~~.~~, Talon, R~~.~~, Krojer, T~~.~~, Bountra, C~~., ~~Arrowsmith, C~~.H., ~~Edwards~~, A., ~~London, N~~., ~~von Delft, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qit]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QIT FirstGlance]. <br>
-	~~Description~~: ~~Covalent fragment group deposition~~ --~~Crystal Structure of OUTB2 in complex~~ with ~~PCM~~-~~0102821~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J5J:N-[(E)-(3-methylphenyl)methylidene]acetamide'>J5J</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qit OCA], [http://pdbe.org/5qit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qit RCSB], [http://www.ebi.ac.uk/pdbsum/5qit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qit ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ubiquitinyl hydrolase 1]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Bradley, A R]]
		+	[[Category: Brandao-Neto, J]]
	[[Category: Collins, P]]		[[Category: Collins, P]]
-	[[Category: ~~Bradley~~, ~~A.R~~]]	+	[[Category: Delft, F von]]
-	[[Category: ~~Arrowsmith~~, ~~C.H]]~~	+	[[Category: Douangamath, A]]
-	~~[[Category: Talon, R]]~~	+
-	~~[[Category: Brandao-Neto, J~~]]	+
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
-	[[Category: Douangamath, A]]
	[[Category: Krojer, T]]		[[Category: Krojer, T]]
		+	[[Category: London, N]]
	[[Category: Resnick, E]]		[[Category: Resnick, E]]
-	[[Category: Von Delft, F]]
	[[Category: Sethi, R]]		[[Category: Sethi, R]]
-	[[Category: ~~Bountra~~, C]]	+	[[Category: Talon, R]]
-	[[Category: ~~London, N~~]]	+	[[Category: Deubiquitinating enzyme otub2]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Protease otub2]]
		+	[[Category: Sgc - diamond i04-1 fragment screening]]
		+	[[Category: Xchemexplorer]]

OCA: Protected "5qit" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2018 04:31:13 GMT

Protected "5qit" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:31, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 5qit is ON HOLD Authors: Sethi, R., Douangamath, A., Resnick, E., Bradley, A.R., Collins, P., Brandao-Neto, J., Talon, R., Krojer, T., Bountra, C., ...

OCA — Wed, 22 Aug 2018 04:31:11 GMT

New page: '''Unreleased structure''' The entry 5qit is ON HOLD Authors: Sethi, R., Douangamath, A., Resnick, E., Bradley, A.R., Collins, P., Brandao-Neto, J., Talon, R., Krojer, T., Bountra, C., ...

New page

'''Unreleased structure'''

The entry 5qit is ON HOLD

Authors: Sethi, R., Douangamath, A., Resnick, E., Bradley, A.R., Collins, P., Brandao-Neto, J., Talon, R., Krojer, T., Bountra, C., Arrowsmith, C.H., Edwards, A., London, N., von Delft, F.

Description: Covalent fragment group deposition --Crystal Structure of OUTB2 in complex with PCM-0102821
[[Category: Unreleased Structures]]
[[Category: Collins, P]]
[[Category: Bradley, A.R]]
[[Category: Arrowsmith, C.H]]
[[Category: Talon, R]]
[[Category: Brandao-Neto, J]]
[[Category: Edwards, A]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Resnick, E]]
[[Category: Von Delft, F]]
[[Category: Sethi, R]]
[[Category: Bountra, C]]
[[Category: London, N]]