5qj3 - Revision history

OCA at 08:56, 7 February 2024

OCA — Wed, 07 Feb 2024 08:56:15 GMT

←Older revision		Revision as of 08:56, 7 February 2024
Line 1:		Line 1:

-	====	+	==CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-24 AKA 7-({4-CHLORO-3'-FLUORO-[1,1'- BIPHENYL]-3-YL}METHOXY)-3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN- 5-AMINE==
-	<StructureSection load='5qj3' size='340' side='right'caption='[[5qj3]]' scene=''>	+	<StructureSection load='5qj3' size='340' side='right'caption='[[5qj3]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qj3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QJ3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj3 OCA], [https://pdbe.org/5qj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qj3 RCSB], [https://www.ebi.ac.uk/pdbsum/5qj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj3 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.76Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JXP:7-[(4-chloro-3-fluoro[1,1-biphenyl]-3-yl)methoxy]-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine'>JXP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj3 OCA], [https://pdbe.org/5qj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qj3 RCSB], [https://www.ebi.ac.uk/pdbsum/5qj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[https://omim.org/entry/254600 254600]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
		+
		+	==See Also==
		+	*[[Myeloperoxidase\|Myeloperoxidase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Khan JA]]

OCA at 10:11, 18 March 2021

OCA — Thu, 18 Mar 2021 10:11:38 GMT

←Older revision		Revision as of 10:11, 18 March 2021
Line 3:		Line 3:
	<StructureSection load='5qj3' size='340' side='right'caption='[[5qj3]]' scene=''>		<StructureSection load='5qj3' size='340' side='right'caption='[[5qj3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5qj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj3 OCA], [~~http~~://pdbe.org/5qj3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qj3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qj3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj3 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj3 OCA], [https://pdbe.org/5qj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qj3 RCSB], [https://www.ebi.ac.uk/pdbsum/5qj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj3 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 11:10, 16 September 2020

OCA — Wed, 16 Sep 2020 11:10:58 GMT

←Older revision		Revision as of 11:10, 16 September 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qj3 ~~is ON HOLD~~	+	====
-		+	<StructureSection load='5qj3' size='340' side='right'caption='[[5qj3]]' scene=''>
-	~~Authors~~: ~~Khan, J~~.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-24 AKA 7-({4-CHLORO-3~~'~~-FLUORO-~~[1,1'-~~BIPHENYL~~]~~-3-YL}METHOXY)-3H-~~[1,~~2,3~~]~~TRIAZOLO~~[4,5-B]~~PYRIDIN-5-AMINE~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5qj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj3 OCA], [http://pdbe.org/5qj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qj3 RCSB], [http://www.ebi.ac.uk/pdbsum/5qj3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj3 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Khan, J.A~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "5qj3" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2018 06:08:17 GMT

Protected "5qj3" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:08, 3 October 2018

OCA: New page: '''Unreleased structure''' The entry 5qj3 is ON HOLD Authors: Khan, J.A. Description: CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-24 AKA 7-({4-CHLORO-3'-...

OCA — Wed, 03 Oct 2018 06:08:16 GMT

New page: '''Unreleased structure''' The entry 5qj3 is ON HOLD Authors: Khan, J.A. Description: CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-24 AKA 7-({4-CHLORO-3'-...

New page

'''Unreleased structure'''

The entry 5qj3 is ON HOLD

Authors: Khan, J.A.

Description: CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-24 AKA 7-({4-CHLORO-3'-FLUORO-[1,1'-BIPHENYL]-3-YL}METHOXY)-3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE
[[Category: Unreleased Structures]]
[[Category: Khan, J.A]]