5qqf - Revision history

OCA at 10:10, 14 February 2024

OCA — Wed, 14 Feb 2024 10:10:49 GMT

←Older revision		Revision as of 10:10, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='5qqf' size='340' side='right'caption='[[5qqf]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='5qqf' size='340' side='right'caption='[[5qqf]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qqf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QQF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qqf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QQF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=EDO:1,2-ETHANEDIOL'~~>~~EDO</scene>, <scene name='pdbligand=N5V:N~~-~~ethyl-N-1~~,~~3-thiazol-~~2~~-ylurea'>N5V</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http~~:~~//en.wikipedia.org/wiki/Non~~-~~specific_serine/threonine_protein_kinase Non~~-~~specific serine/threonine protein kinase]~~, ~~with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.7.11.1 2.7.11.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=N5V:N-ethyl-N-1,3-thiazol-2-ylurea'>N5V</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqf OCA], [~~http~~://pdbe.org/5qqf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qqf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qqf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqf OCA], [https://pdbe.org/5qqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qqf RCSB], [https://www.ebi.ac.uk/pdbsum/5qqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqf ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RAC1_HUMAN RAC1_HUMAN]] Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> [[~~http://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN~~]] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.<ref>PMID:10023074</ref>	+	[https://www.uniprot.org/uniprot/RAC1_HUMAN RAC1_HUMAN] Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref>
		+
		+	==See Also==
		+	*[[Rac 3D structures\|Rac 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Arrowsmith CH]]
-	~~[[Category: Antunez, C Jimenez]]~~	+	[[Category: Bountra C]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Brennan PE]]
-	[[Category: Bountra, C]]	+	[[Category: Douangamath A]]
-	[[Category: Brennan~~, P E~~]]	+	[[Category: Edwards A]]
-	[[Category: ~~Delft, F von~~]]	+	[[Category: Gray JL]]
-	[[Category: ~~Douangamath,~~ A]]	+	[[Category: Jimenez Antunez C]]
-	[[Category: ~~Edwards, A~~]]	+	[[Category: Krojer T]]
-	[[Category: ~~Gray, J L~~]]	+	[[Category: Talon R]]
-	[[Category: Krojer, T]]	+	[[Category: Von Delft F]]
-	[[Category: Talon, R]]	+
-	[[Category: ~~Hydrolase-transferase complex]]~~	+
-	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~	+
-	~~[[Category: Xchemexplorer~~]]	+

OCA at 07:35, 18 December 2019

OCA — Wed, 18 Dec 2019 07:35:53 GMT

←Older revision		Revision as of 07:35, 18 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qqf ~~is ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-004-412-710==
-		+	<StructureSection load='5qqf' size='340' side='right'caption='[[5qqf]], [[Resolution\|resolution]] 2.26Å' scene=''>
-	~~Authors~~: ~~Gray, J~~.L.~~, Krojer, T~~.~~, Talon, R~~.~~, Douangamath, A~~., ~~Jimenez Antunez~~, C., ~~Bountra, C~~., ~~Arrowsmith, C~~.H., ~~Edwards~~, A., ~~Brennan, P~~.E., ~~von Delft, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qqf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QQF FirstGlance]. <br>
-	~~Description~~: ~~PanDDA analysis group deposition~~ --~~Crystal Structure~~ of ~~Kalirin/~~Rac1 in ~~complex~~ with ~~MolPort~~-~~004~~-~~412~~-~~710~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=N5V:N-ethyl-N-1,3-thiazol-2-ylurea'>N5V</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	[[Category: ~~Jimenez~~ Antunez, C]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqf OCA], [http://pdbe.org/5qqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qqf RCSB], [http://www.ebi.ac.uk/pdbsum/5qqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqf ProSAT]</span></td></tr>
-	[[Category: Arrowsmith, C.H]]	+	</table>
-	[[Category: ~~Talon~~, R]]	+	== Disease ==
-	[[Category: ~~Gray~~, ~~J.L~~]]	+	[[http://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.
-	[[Category: ~~Brennan~~, ~~P.E~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAC1_HUMAN RAC1_HUMAN]] Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> [[http://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN]] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.<ref>PMID:10023074</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Antunez, C Jimenez]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Brennan, P E]]
		+	[[Category: Delft, F von]]
		+	[[Category: Douangamath, A]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
-	[[Category: ~~Douangamath~~, A]]	+	[[Category: Gray, J L]]
	[[Category: Krojer, T]]		[[Category: Krojer, T]]
-	[[Category: ~~Von Delft~~, F]]	+	[[Category: Talon, R]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Hydrolase-transferase complex]]
		+	[[Category: Sgc - diamond i04-1 fragment screening]]
		+	[[Category: Xchemexplorer]]

OCA: Protected "5qqf" [edit=sysop:move=sysop]

OCA — Tue, 21 May 2019 05:32:59 GMT

Protected "5qqf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 21 May 2019

OCA: New page: '''Unreleased structure''' The entry 5qqf is ON HOLD Authors: Gray, J.L., Krojer, T., Talon, R., Douangamath, A., Jimenez Antunez, C., Bountra, C., Arrowsmith, C.H., Edwards, A., Brenna...

OCA — Tue, 21 May 2019 05:32:57 GMT

New page: '''Unreleased structure''' The entry 5qqf is ON HOLD Authors: Gray, J.L., Krojer, T., Talon, R., Douangamath, A., Jimenez Antunez, C., Bountra, C., Arrowsmith, C.H., Edwards, A., Brenna...

New page

'''Unreleased structure'''

The entry 5qqf is ON HOLD

Authors: Gray, J.L., Krojer, T., Talon, R., Douangamath, A., Jimenez Antunez, C., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P.E., von Delft, F.

Description: PanDDA analysis group deposition --Crystal Structure of Kalirin/Rac1 in complex with MolPort-004-412-710
[[Category: Unreleased Structures]]
[[Category: Jimenez Antunez, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Talon, R]]
[[Category: Gray, J.L]]
[[Category: Brennan, P.E]]
[[Category: Edwards, A]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]