5qr8 - Revision history

OCA at 11:25, 21 February 2024

OCA — Wed, 21 Feb 2024 11:25:13 GMT

←Older revision		Revision as of 11:25, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='5qr8' size='340' side='right'caption='[[5qr8]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5qr8' size='340' side='right'caption='[[5qr8]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qr8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QR8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QR8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NVD:N-{[4-(dimethylamino)phenyl]methyl}-4H-1,2,4-triazol-4-amine'>NVD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NVD:N-{[4-(dimethylamino)phenyl]methyl}-4H-1,2,4-triazol-4-amine'>NVD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qr8 OCA], [~~http~~://pdbe.org/5qr8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qr8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qr8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qr8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qr8 OCA], [https://pdbe.org/5qr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qr8 RCSB], [https://www.ebi.ac.uk/pdbsum/5qr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qr8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>	+	[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~5-aminolevulinate synthase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bailey, H]]	+	[[Category: Bailey H]]
-	[[Category: Bezerra~~, G A~~]]	+	[[Category: Bezerra GA]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Brandao-Neto, J]]	+	[[Category: Brandao-Neto J]]
-	[[Category: Brennan~~, P E]]~~	+	[[Category: Brennan PE]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Douangamath A]]
-	[[Category: Douangamath, A]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Foster W]]
-	[[Category: Foster, W]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Nicola BB]]
-	[[Category: Nicola~~, B B~~]]	+	[[Category: Shrestha L]]
-	[[Category: Shrestha, L]]	+	[[Category: Talon R]]
-	[[Category: Talon, R]]	+	[[Category: Yue WW]]
-	[[Category: Yue~~, W W~~]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Pandda]]~~	+
-	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Xchemexplorer~~]]	+

OCA at 05:44, 7 August 2019

OCA — Wed, 07 Aug 2019 05:44:44 GMT

←Older revision		Revision as of 05:44, 7 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qr8 ~~is ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z57258487==
-		+	<StructureSection load='5qr8' size='340' side='right'caption='[[5qr8]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~Authors~~: ~~Bezerra, G~~.A.~~, Foster, W~~.~~, Bailey, H~~.~~, Shrestha, L~~.~~, Krojer, T~~.~~, Talon, R~~.~~, Brandao~~-~~Neto, J~~.~~, Douangamath, A~~., ~~Nicola~~, B.B., ~~von Delft, F~~., ~~Arrowsmith, C~~.H., ~~Edwards, A~~., ~~Bountra, C~~., ~~Brennan, P~~.E., ~~Yue, W~~.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qr8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QR8 FirstGlance]. <br>
-	~~Description~~: ~~PanDDA analysis group deposition~~ -~~-Crystal Structure~~ of ~~human ALAS2A~~ in ~~complex with Z57258487~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NVD:N-{[4-(dimethylamino)phenyl]methyl}-4H-1,2,4-triazol-4-amine'>NVD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	[[Category: ~~Foster, W~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qr8 OCA], [http://pdbe.org/5qr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qr8 RCSB], [http://www.ebi.ac.uk/pdbsum/5qr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qr8 ProSAT]</span></td></tr>
-	[[Category: Arrowsmith, C.H]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 5-aminolevulinate synthase]]
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bailey, H]]
		+	[[Category: Bezerra, G A]]
		+	[[Category: Bountra, C]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]
-	~~[[Category: Talon, R]]~~	+	[[Category: Brennan, P E]]
-	[[Category: Brennan, P.E]]	+	[[Category: Delft, F von]]
-	[[Category: ~~Shrestha~~, L]]	+	[[Category: Douangamath, A]]
-	[[Category: ~~Bezerra~~, G.A]]	+
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
-	[[Category: ~~Nicola~~, ~~B.B]]~~	+	[[Category: Foster, W]]
-	~~[[Category: Douangamath, A~~]]	+
	[[Category: Krojer, T]]		[[Category: Krojer, T]]
-	[[Category: ~~Yue~~, ~~W.W~~]]	+	[[Category: Nicola, B B]]
-	[[Category: ~~Von Delft~~, F]]	+	[[Category: Shrestha, L]]
-	[[Category: ~~Bailey~~, H]]	+	[[Category: Talon, R]]
-	[[Category: ~~Bountra~~, C]]	+	[[Category: Yue, W W]]
		+	[[Category: Pandda]]
		+	[[Category: Sgc - diamond i04-1 fragment screening]]
		+	[[Category: Transferase]]
		+	[[Category: Xchemexplorer]]

OCA at 03:54, 10 July 2019

OCA — Wed, 10 Jul 2019 03:54:59 GMT

←Older revision		Revision as of 03:54, 10 July 2019
Line 3:		Line 3:
	The entry 5qr8 is ON HOLD		The entry 5qr8 is ON HOLD

-	Authors: Bezerra, G.A., Foster, W., Shrestha L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.	+	Authors: Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.

	Description: PanDDA analysis group deposition --Crystal Structure of human ALAS2A in complex with Z57258487		Description: PanDDA analysis group deposition --Crystal Structure of human ALAS2A in complex with Z57258487
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Foster, W]]		[[Category: Foster, W]]
-	[[Category: Shrestha L]]
	[[Category: Arrowsmith, C.H]]		[[Category: Arrowsmith, C.H]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]
	[[Category: Talon, R]]		[[Category: Talon, R]]
	[[Category: Brennan, P.E]]		[[Category: Brennan, P.E]]
		+	[[Category: Shrestha, L]]
	[[Category: Bezerra, G.A]]		[[Category: Bezerra, G.A]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
Line 20:		Line 20:
	[[Category: Yue, W.W]]		[[Category: Yue, W.W]]
	[[Category: Von Delft, F]]		[[Category: Von Delft, F]]
		+	[[Category: Bailey, H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA: Protected "5qr8" [edit=sysop:move=sysop]

OCA — Wed, 29 May 2019 04:10:10 GMT

Protected "5qr8" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 29 May 2019

OCA: New page: '''Unreleased structure''' The entry 5qr8 is ON HOLD Authors: Bezerra, G.A., Foster, W., Shrestha L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, ...

OCA — Wed, 29 May 2019 04:10:08 GMT

New page: '''Unreleased structure''' The entry 5qr8 is ON HOLD Authors: Bezerra, G.A., Foster, W., Shrestha L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, ...

New page

'''Unreleased structure'''

The entry 5qr8 is ON HOLD

Authors: Bezerra, G.A., Foster, W., Shrestha L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.

Description: PanDDA analysis group deposition --Crystal Structure of human ALAS2A in complex with Z57258487
[[Category: Unreleased Structures]]
[[Category: Foster, W]]
[[Category: Shrestha L]]
[[Category: Arrowsmith, C.H]]
[[Category: Brandao-Neto, J]]
[[Category: Talon, R]]
[[Category: Brennan, P.E]]
[[Category: Bezerra, G.A]]
[[Category: Edwards, A]]
[[Category: Nicola, B.B]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Yue, W.W]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]