5qsb - Revision history

OCA at 11:26, 21 February 2024

OCA — Wed, 21 Feb 2024 11:26:27 GMT

←Older revision		Revision as of 11:26, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='5qsb' size='340' side='right'caption='[[5qsb]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='5qsb' size='340' side='right'caption='[[5qsb]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qsb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QSB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QSB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QSB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O0M:1-{[4-(propan-2-yl)phenyl]methyl}piperidin-4-ol'>O0M</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qsb OCA], [~~http~~://pdbe.org/5qsb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qsb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qsb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qsb ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O0M:1-{[4-(propan-2-yl)phenyl]methyl}piperidin-4-ol'>O0M</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qsb OCA], [https://pdbe.org/5qsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qsb RCSB], [https://www.ebi.ac.uk/pdbsum/5qsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qsb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]	+	[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
		+
		+	==See Also==
		+	*[[Brachyury\|Brachyury]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Burgess-Brown~~, N A]]~~	+	[[Category: Burgess-Brown NA]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Gavard AE]]
-	[[Category: Gavard~~, A E~~]]	+	[[Category: Gileadi O]]
-	[[Category: Gileadi, O]]	+	[[Category: Newman JA]]
-	[[Category: Newman~~, J A~~]]	+	[[Category: Sherestha L]]
-	[[Category: Sherestha, L]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Pandda]]~~	+
-	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Xchemexplorer~~]]	+

OCA at 05:46, 21 August 2019

OCA — Wed, 21 Aug 2019 05:46:01 GMT

←Older revision		Revision as of 05:46, 21 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qsb is ~~ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2856434874==
-		+	<StructureSection load='5qsb' size='340' side='right'caption='[[5qsb]], [[Resolution\|resolution]] 1.82Å' scene=''>
-	~~Authors~~: ~~Newman~~, J.A., ~~Gavard~~, A.E., ~~Sherestha~~, L., Burgess-Brown, N.A~~., von~~ Delft, F~~., Arrowsmith, C.H.,~~ Edwards, A~~., Bountra, C.~~, Gileadi, O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qsb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QSB FirstGlance]. <br>
-	~~Description: PanDDA analysis group deposition --Crystal Structure of human Brachyury G177D variant in complex with Z2856434874~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O0M:1-{[4-(propan-2-yl)phenyl]methyl}piperidin-4-ol'>O0M</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qsb OCA], [http://pdbe.org/5qsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qsb RCSB], [http://www.ebi.ac.uk/pdbsum/5qsb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qsb ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Burgess-Brown, N A]]
		+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A]]
		+	[[Category: Gavard, A E]]
		+	[[Category: Gileadi, O]]
		+	[[Category: Newman, J A]]
	[[Category: Sherestha, L]]		[[Category: Sherestha, L]]
-	[[Category: ~~Arrowsmith, C.H~~]]	+	[[Category: Pandda]]
-	[[Category: ~~Gileadi, O]]~~	+	[[Category: Sgc - diamond i04-1 fragment screening]]
-	~~[[Category: Newman, J.A]]~~	+	[[Category: Transcription]]
-	~~[[Category: Edwards, A]]~~	+	[[Category: Xchemexplorer]]
-	~~[[Category: Burgess~~-~~Brown, N.A]]~~	+
-	~~[[Category: Gavard, A.E~~]]	+
-	[[Category: ~~Von Delft, F~~]]	+
-	[[Category: ~~Bountra, C~~]]	+

OCA: Protected "5qsb" [edit=sysop:move=sysop]

OCA — Wed, 05 Jun 2019 20:50:56 GMT

Protected "5qsb" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:50, 5 June 2019

OCA: New page: '''Unreleased structure''' The entry 5qsb is ON HOLD Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., ...

OCA — Wed, 05 Jun 2019 20:50:55 GMT

New page: '''Unreleased structure''' The entry 5qsb is ON HOLD Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., ...

New page

'''Unreleased structure'''

The entry 5qsb is ON HOLD

Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

Description: PanDDA analysis group deposition --Crystal Structure of human Brachyury G177D variant in complex with Z2856434874
[[Category: Unreleased Structures]]
[[Category: Sherestha, L]]
[[Category: Arrowsmith, C.H]]
[[Category: Gileadi, O]]
[[Category: Newman, J.A]]
[[Category: Edwards, A]]
[[Category: Burgess-Brown, N.A]]
[[Category: Gavard, A.E]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]