5qxr - Revision history

OCA at 11:28, 21 February 2024

OCA — Wed, 21 Feb 2024 11:28:50 GMT

←Older revision		Revision as of 11:28, 21 February 2024
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	<StructureSection load='5qxr' size='340' side='right'caption='[[5qxr]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='5qxr' size='340' side='right'caption='[[5qxr]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qxr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5QXR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QXR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RHY:1-[(4aS,7aS,9S)-3,4,7,7a,8,9-hexahydro-4a,9-epoxypyrrolo[3,4 4,5]cyclohepta[1,2-d]imidazol-6(5H)-yl]ethan-1-one'>RHY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.66Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RHY:1-[(4aS,7aS,9S)-3,4,7,7a,8,9-hexahydro-4a,9-epoxypyrrolo[3,4 4,5]cyclohepta[1,2-d]imidazol-6(5H)-yl]ethan-1-one'>RHY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5qxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxr OCA], [~~http~~://pdbe.org/5qxr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qxr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qxr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxr OCA], [https://pdbe.org/5qxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qxr RCSB], [https://www.ebi.ac.uk/pdbsum/5qxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>	+	[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+
		+	==See Also==
		+	*[[ATPase family AAA domain-containing protein\|ATPase family AAA domain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenosinetriphosphatase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Collins, P]]	+	[[Category: Collins P]]
-	[[Category: Edwards, A]]	+	[[Category: Edwards A]]
-	[[Category: Fowley, D]]	+	[[Category: Fowley D]]
-	[[Category: Nelson, A]]	+	[[Category: Nelson A]]
-	[[Category: Snee, M]]	+	[[Category: Snee M]]
-	[[Category: Talon, R]]	+	[[Category: Talon R]]
-	[[Category: Von-Delft, F]]	+	[[Category: Von-Delft F]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Pandda]]~~	+
-	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~	+
-	~~[[Category: Xchemexplorer~~]]	+

OCA at 06:45, 8 April 2020

OCA — Wed, 08 Apr 2020 06:45:15 GMT

←Older revision		Revision as of 06:45, 8 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qxr ~~is ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with DF849==
-		+	<StructureSection load='5qxr' size='340' side='right'caption='[[5qxr]], [[Resolution\|resolution]] 1.66Å' scene=''>
-	~~Authors~~: ~~Snee, M~~., ~~Talon~~, R., ~~Fowley~~, D., ~~Collins~~, P., ~~Nelson~~, A., ~~Arrowsmith~~, C.H., ~~Bountra~~, C., ~~Edwards~~, A., ~~Von-Delft~~, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qxr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5QXR FirstGlance]. <br>
-	~~Description~~: ~~PanDDA analysis group deposition --Crystal Structure~~ of ~~ATAD2~~ in ~~complex with DF849~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RHY:1-[(4aS,7aS,9S)-3,4,7,7a,8,9-hexahydro-4a,9-epoxypyrrolo[3,4 4,5]cyclohepta[1,2-d]imidazol-6(5H)-yl]ethan-1-one'>RHY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5qxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxr OCA], [http://pdbe.org/5qxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qxr RCSB], [http://www.ebi.ac.uk/pdbsum/5qxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adenosinetriphosphatase]]
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Collins, P]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
-	[[Category: ~~Collins~~, P]]	+	[[Category: Fowley, D]]
		+	[[Category: Nelson, A]]
	[[Category: Snee, M]]		[[Category: Snee, M]]
-	[[Category: Bountra, C]]
-	[[Category: Arrowsmith, C.H]]
-	[[Category: Nelson, A]]
-	[[Category: Fowley, D]]
	[[Category: Talon, R]]		[[Category: Talon, R]]
	[[Category: Von-Delft, F]]		[[Category: Von-Delft, F]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Pandda]]
		+	[[Category: Sgc - diamond i04-1 fragment screening]]
		+	[[Category: Xchemexplorer]]

OCA: Protected "5qxr" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2020 04:55:58 GMT

Protected "5qxr" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 19 February 2020

OCA: New page: '''Unreleased structure''' The entry 5qxr is ON HOLD Authors: Snee, M., Talon, R., Fowley, D., Collins, P., Nelson, A., Arrowsmith, C.H., Bountra, C., Edwards, A., Von-Delft, F. Descri...

OCA — Wed, 19 Feb 2020 04:55:57 GMT

New page: '''Unreleased structure''' The entry 5qxr is ON HOLD Authors: Snee, M., Talon, R., Fowley, D., Collins, P., Nelson, A., Arrowsmith, C.H., Bountra, C., Edwards, A., Von-Delft, F. Descri...

New page

'''Unreleased structure'''

The entry 5qxr is ON HOLD

Authors: Snee, M., Talon, R., Fowley, D., Collins, P., Nelson, A., Arrowsmith, C.H., Bountra, C., Edwards, A., Von-Delft, F.

Description: PanDDA analysis group deposition --Crystal Structure of ATAD2 in complex with DF849
[[Category: Unreleased Structures]]
[[Category: Edwards, A]]
[[Category: Collins, P]]
[[Category: Snee, M]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Nelson, A]]
[[Category: Fowley, D]]
[[Category: Talon, R]]
[[Category: Von-Delft, F]]