5r4y - Revision history

OCA at 11:35, 21 February 2024

OCA — Wed, 21 Feb 2024 11:35:47 GMT

←Older revision		Revision as of 11:35, 21 February 2024
Line 1:		Line 1:

	==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a==		==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a==
-	<StructureSection load='5r4y' size='340' side='right'caption='[[5r4y]]' scene=''>	+	<StructureSection load='5r4y' size='340' side='right'caption='[[5r4y]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5R4Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5r4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R4Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5r4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4y OCA], [~~http~~://pdbe.org/5r4y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5r4y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5r4y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4y ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.84Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GX4:cyclopropyl-[4-(4-fluorophenyl)piperazin-1-yl]methanone'>GX4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4y OCA], [https://pdbe.org/5r4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r4y RCSB], [https://www.ebi.ac.uk/pdbsum/5r4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+
		+	==See Also==
		+	*[[ATPase family AAA domain-containing protein\|ATPase family AAA domain-containing protein]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Aimon A]]		[[Category: Aimon A]]

OCA at 05:22, 13 May 2020

OCA — Wed, 13 May 2020 05:22:20 GMT

←Older revision		Revision as of 05:22, 13 May 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 5r4y ~~is ON HOLD~~	+	==XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a==
-		+	<StructureSection load='5r4y' size='340' side='right'caption='[[5r4y]]' scene=''>
-	~~Authors~~: ~~Talon, R~~.~~, Krojer, T~~.~~, Fairhead, M~~.~~, Sethi, R~~.~~, Bradley, A~~.R.~~, Aimon, A~~.~~, Collins, P~~.~~, Brandao-Neto, J~~., ~~Douangamath, A~~.~~, Wright, N~~.~~, MacLean, E~~., ~~Renjie, Z~~., ~~Dias, A~~.~~, Brennan, P~~.E., ~~Bountra, C~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.~~, von Delft, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R4Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5R4Y FirstGlance]. <br>
-	~~Description: XChem fragment screen --CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5r4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r4y OCA], [http://pdbe.org/5r4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5r4y RCSB], [http://www.ebi.ac.uk/pdbsum/5r4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5r4y ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Aimon, A]]	+	__TOC__
-	[[Category: ~~Collins, P~~]]	+	</StructureSection>
-	[[Category: ~~Arrowsmith,~~ C.H]]	+	[[Category: Large Structures]]
-	[[Category: ~~Brandao-Neto, J~~]]	+	[[Category: Aimon A]]
-	[[Category: ~~Fairhead, M~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Bountra C]]
-	[[Category: ~~Renjie, Z~~]]	+	[[Category: Bradley AR]]
-	[[Category: ~~Wright, N~~]]	+	[[Category: Brandao-Neto J]]
-	[[Category: ~~Bradley,~~ A.R]]	+	[[Category: Brennan PE]]
-	[[Category: ~~Talon, R~~]]	+	[[Category: Collins P]]
-	[[Category: ~~Brennan, P.E~~]]	+	[[Category: Dias A]]
-	[[Category: ~~Edwards, A~~]]	+	[[Category: Douangamath A]]
-	[[Category: ~~Maclean,~~ E]]	+	[[Category: Edwards A]]
-	[[Category: ~~Douangamath, A~~]]	+	[[Category: Fairhead M]]
-	[[Category: ~~Krojer, T~~]]	+	[[Category: Krojer T]]
-	[[Category: ~~Dias, A~~]]	+	[[Category: MacLean E]]
-	[[Category: ~~Sethi,~~ R]]	+	[[Category: Sethi R]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Talon R]]
		+	[[Category: Wright N]]
		+	[[Category: Zhang R]]
		+	[[Category: Von Delft F]]

OCA: Protected "5r4y" [edit=sysop:move=sysop]

OCA — Wed, 11 Mar 2020 05:46:02 GMT

Protected "5r4y" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:46, 11 March 2020

OCA: New page: '''Unreleased structure''' The entry 5r4y is ON HOLD Authors: Talon, R., Krojer, T., Fairhead, M., Sethi, R., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., W...

OCA — Wed, 11 Mar 2020 05:46:00 GMT

New page: '''Unreleased structure''' The entry 5r4y is ON HOLD Authors: Talon, R., Krojer, T., Fairhead, M., Sethi, R., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., W...

New page

'''Unreleased structure'''

The entry 5r4y is ON HOLD

Authors: Talon, R., Krojer, T., Fairhead, M., Sethi, R., Bradley, A.R., Aimon, A., Collins, P., Brandao-Neto, J., Douangamath, A., Wright, N., MacLean, E., Renjie, Z., Dias, A., Brennan, P.E., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.

Description: XChem fragment screen --CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in complex with N13612a
[[Category: Unreleased Structures]]
[[Category: Aimon, A]]
[[Category: Collins, P]]
[[Category: Arrowsmith, C.H]]
[[Category: Brandao-Neto, J]]
[[Category: Fairhead, M]]
[[Category: Von Delft, F]]
[[Category: Renjie, Z]]
[[Category: Wright, N]]
[[Category: Bradley, A.R]]
[[Category: Talon, R]]
[[Category: Brennan, P.E]]
[[Category: Edwards, A]]
[[Category: Maclean, E]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Dias, A]]
[[Category: Sethi, R]]
[[Category: Bountra, C]]