OCA at 13:49, 1 March 2024

OCA — Fri, 01 Mar 2024 13:49:52 GMT

←Older revision		Revision as of 13:49, 1 March 2024
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	==PanDDA analysis group deposition -- Crystal Structure of Zika virus NS3 Helicase in complex with Z198194396==		==PanDDA analysis group deposition -- Crystal Structure of Zika virus NS3 Helicase in complex with Z198194396==
-	<StructureSection load='5rhi' size='340' side='right'caption='[[5rhi]]' scene=''>	+	<StructureSection load='5rhi' size='340' side='right'caption='[[5rhi]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5RHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5rhi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RHI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5rhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhi OCA], [~~http~~://pdbe.org/5rhi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5rhi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5rhi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5rhi ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K2M:4-(furan-2-carbonyl)piperazine-1-carboxamide'>K2M</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhi OCA], [https://pdbe.org/5rhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rhi RCSB], [https://www.ebi.ac.uk/pdbsum/5rhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rhi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763] prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763] Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763] Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763] Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732] Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
		+	*[[Nonstructural protein 3D structures\|Nonstructural protein 3D structures]]
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Zika virus]]
	[[Category: Godoy AS]]		[[Category: Godoy AS]]
	[[Category: Mesquita NCMR]]		[[Category: Mesquita NCMR]]
	[[Category: Oliva G]]		[[Category: Oliva G]]

OCA at 06:21, 10 June 2020

OCA — Wed, 10 Jun 2020 06:21:32 GMT

←Older revision		Revision as of 06:21, 10 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5rhi is ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of Zika virus NS3 Helicase in complex with Z198194396==
-		+	<StructureSection load='5rhi' size='340' side='right'caption='[[5rhi]]' scene=''>
-	~~Authors: Godoy, A.S., Mesquita, N.C.M.R., Oliva, G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5RHI FirstGlance]. <br>
-	~~Description:~~ PanDDA analysis group deposition --Crystal Structure of Zika virus NS3 Helicase in complex with Z198194396	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5rhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhi OCA], [http://pdbe.org/5rhi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5rhi RCSB], [http://www.ebi.ac.uk/pdbsum/5rhi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5rhi ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Mesquita~~, N.C.M.R]]	+	__TOC__
-	[[Category: Godoy~~, A.S~~]]	+	</StructureSection>
-	[[Category: Oliva, G]]	+	[[Category: Large Structures]]
		+	[[Category: Godoy AS]]
		+	[[Category: Mesquita NCMR]]
		+	[[Category: Oliva G]]

OCA: Protected "5rhi" [edit=sysop:move=sysop]

OCA — Wed, 03 Jun 2020 05:04:30 GMT

Protected "5rhi" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 3 June 2020

OCA: New page: '''Unreleased structure''' The entry 5rhi is ON HOLD Authors: Godoy, A.S., Mesquita, N.C.M.R., Oliva, G. Description: PanDDA analysis group deposition --Crystal Structure of Zika virus...

OCA — Wed, 03 Jun 2020 05:04:29 GMT

New page: '''Unreleased structure''' The entry 5rhi is ON HOLD Authors: Godoy, A.S., Mesquita, N.C.M.R., Oliva, G. Description: PanDDA analysis group deposition --Crystal Structure of Zika virus...

New page

'''Unreleased structure'''

The entry 5rhi is ON HOLD

Authors: Godoy, A.S., Mesquita, N.C.M.R., Oliva, G.

Description: PanDDA analysis group deposition --Crystal Structure of Zika virus NS3 Helicase in complex with Z198194396
[[Category: Unreleased Structures]]
[[Category: Mesquita, N.C.M.R]]
[[Category: Godoy, A.S]]
[[Category: Oliva, G]]

5rhi - Revision history

OCA at 13:49, 1 March 2024

OCA at 06:21, 10 June 2020

OCA: Protected "5rhi" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 5rhi is ON HOLD Authors: Godoy, A.S., Mesquita, N.C.M.R., Oliva, G. Description: PanDDA analysis group deposition --Crystal Structure of Zika virus...