OCA at 09:35, 14 February 2024

OCA — Wed, 14 Feb 2024 09:35:44 GMT

←Older revision		Revision as of 09:35, 14 February 2024
Line 1:		Line 1:

	==INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z17497990==		==INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z17497990==
-	<StructureSection load='5rwg' size='340' side='right'caption='[[5rwg]]' scene=''>	+	<StructureSection load='5rwg' size='340' side='right'caption='[[5rwg]], [[Resolution\|resolution]] 1.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RWG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5RWG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5rwg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RWG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5rwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rwg OCA], [~~http~~://pdbe.org/5rwg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5rwg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5rwg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5rwg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.46Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=S07:2-(2,4-dimethylphenoxy)-1-morpholin-4-yl-ethanone'>S07</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rwg OCA], [https://pdbe.org/5rwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rwg RCSB], [https://www.ebi.ac.uk/pdbsum/5rwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rwg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SHIP1_HUMAN SHIP1_HUMAN] Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.<ref>PMID:12421919</ref> <ref>PMID:16682172</ref>
		+
		+	==See Also==
		+	*[[3D structures of inositol polyphosphate 5-phosphatase OCRL\|3D structures of inositol polyphosphate 5-phosphatase OCRL]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith CH]]		[[Category: Arrowsmith CH]]

OCA: Protected "5rwg" [edit=sysop:move=sysop]

OCA — Wed, 11 Nov 2020 07:51:57 GMT

Protected "5rwg" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:51, 11 November 2020

OCA: New page: ==INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z17497990==
OCA — Wed, 11 Nov 2020 07:51:55 GMT

New page: ==INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z17497990== <StructureSection load='5rwg' size='340' side='right'...

New page

==INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z17497990==
<StructureSection load='5rwg' size='340' side='right'caption='[[5rwg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RWG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5RWG FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5rwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rwg OCA], [http://pdbe.org/5rwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5rwg RCSB], [http://www.ebi.ac.uk/pdbsum/5rwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5rwg ProSAT]</span></td></tr>
</table>
TOC
</StructureSection>
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Bradshaw WJ]]
[[Category: Edwards AM]]
[[Category: Gileadi O]]
[[Category: Newman JA]]
[[Category: Von Delft F]]

5rwg - Revision history

OCA at 09:35, 14 February 2024

OCA: Protected "5rwg" [edit=sysop:move=sysop]