5s88 - Revision history

OCA at 14:16, 6 March 2024

OCA — Wed, 06 Mar 2024 14:16:34 GMT

←Older revision		Revision as of 14:16, 6 March 2024
Line 1:		Line 1:

	==XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010954a==		==XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010954a==
-	<StructureSection load='5s88' size='340' side='right'caption='[[5s88]]' scene=''>	+	<StructureSection load='5s88' size='340' side='right'caption='[[5s88]], [[Resolution\|resolution]] 1.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5S88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5S88 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5s88]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5S88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5S88 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5s88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5s88 OCA], [https://pdbe.org/5s88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5s88 RCSB], [https://www.ebi.ac.uk/pdbsum/5s88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5s88 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.31Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LU8:4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine'>LU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XKS:azetidin-3-ol'>XKS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5s88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5s88 OCA], [https://pdbe.org/5s88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5s88 RCSB], [https://www.ebi.ac.uk/pdbsum/5s88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5s88 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Adamson RJ]]		[[Category: Adamson RJ]]

OCA at 07:28, 25 June 2021

OCA — Fri, 25 Jun 2021 07:28:04 GMT

←Older revision		Revision as of 07:28, 25 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 5s88 ~~is ON HOLD~~	+	==XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010954a==
-		+	<StructureSection load='5s88' size='340' side='right'caption='[[5s88]]' scene=''>
-	~~Authors~~: ~~Williams, E~~.P.~~, Adamson, R~~.J.~~, Smil, D~~.~~, Krojer, T~~., ~~Burgess~~-~~Brown~~, N., ~~von Delft, F~~., ~~Bountra, C~~., ~~Bullock, A~~.N.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5S88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5S88 FirstGlance]. <br>
-	~~Description: XChem group deposition --Crystal Structure of human ACVR1 in complex with FM010954a~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5s88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5s88 OCA], [https://pdbe.org/5s88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5s88 RCSB], [https://www.ebi.ac.uk/pdbsum/5s88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5s88 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Adamson~~, R.J~~]]	+	__TOC__
-	[[Category: ~~Krojer, T~~]]	+	</StructureSection>
-	[[Category: ~~Smil, D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Adamson RJ]]
-	[[Category: ~~Williams, E.P~~]]	+	[[Category: Bountra C]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Bullock AN]]
-	[[Category: ~~Burgess-Brown, N~~]]	+	[[Category: Burgess-Brown N]]
-	[[Category: ~~Bullock, A.N~~]]	+	[[Category: Krojer T]]
		+	[[Category: Smil D]]
		+	[[Category: Williams EP]]
		+	[[Category: Von Delft F]]

OCA: Protected "5s88" [edit=sysop:move=sysop]

OCA — Thu, 24 Dec 2020 07:29:46 GMT

Protected "5s88" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:29, 24 December 2020

OCA: New page: '''Unreleased structure''' The entry 5s88 is ON HOLD Authors: Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N. Descript...

OCA — Thu, 24 Dec 2020 07:29:45 GMT

New page: '''Unreleased structure''' The entry 5s88 is ON HOLD Authors: Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N. Descript...

New page

'''Unreleased structure'''

The entry 5s88 is ON HOLD

Authors: Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N.

Description: XChem group deposition --Crystal Structure of human ACVR1 in complex with FM010954a
[[Category: Unreleased Structures]]
[[Category: Adamson, R.J]]
[[Category: Krojer, T]]
[[Category: Smil, D]]
[[Category: Von Delft, F]]
[[Category: Williams, E.P]]
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N]]
[[Category: Bullock, A.N]]