5sd6 - Revision history

OCA at 15:30, 6 March 2024

OCA — Wed, 06 Mar 2024 15:30:51 GMT

←Older revision		Revision as of 15:30, 6 March 2024
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	<StructureSection load='5sd6' size='340' side='right'caption='[[5sd6]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='5sd6' size='340' side='right'caption='[[5sd6]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5sd6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5sd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SD6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HXV:6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine'>HXV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HXV:6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine'>HXV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sd6 OCA], [https://pdbe.org/5sd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sd6 RCSB], [https://www.ebi.ac.uk/pdbsum/5sd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sd6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sd6 OCA], [https://pdbe.org/5sd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sd6 RCSB], [https://www.ebi.ac.uk/pdbsum/5sd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sd6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrofolate reductase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Structural genomic]]
-	[[Category: Dhfr]]
-	[[Category: Folate]]
-	[[Category: Homo sapien]]
-	[[Category: Nadp]]
-	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
-	[[Category: Ssgcid]]

OCA at 07:21, 2 March 2022

OCA — Wed, 02 Mar 2022 07:21:25 GMT

←Older revision		Revision as of 07:21, 2 March 2022
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	==Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892==		==Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892==
-	<StructureSection load='5sd6' size='340' side='right'caption='[[5sd6]]' scene=''>	+	<StructureSection load='5sd6' size='340' side='right'caption='[[5sd6]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SD6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5sd6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SD6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sd6 OCA], [https://pdbe.org/5sd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sd6 RCSB], [https://www.ebi.ac.uk/pdbsum/5sd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sd6 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HXV:6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine'>HXV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sd6 OCA], [https://pdbe.org/5sd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sd6 RCSB], [https://www.ebi.ac.uk/pdbsum/5sd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sd6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dihydrofolate reductase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Structural genomic]]
		+	[[Category: Dhfr]]
		+	[[Category: Folate]]
		+	[[Category: Homo sapien]]
		+	[[Category: Nadp]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Ssgcid]]

OCA at 07:20, 9 February 2022

OCA — Wed, 09 Feb 2022 07:20:53 GMT

←Older revision		Revision as of 07:20, 9 February 2022
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-	'''Unreleased structure'''

-	~~The entry 5sd6 is ON HOLD~~	+	==Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892==
-		+	<StructureSection load='5sd6' size='340' side='right'caption='[[5sd6]]' scene=''>
-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SD6 FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sd6 OCA], [https://pdbe.org/5sd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sd6 RCSB], [https://www.ebi.ac.uk/pdbsum/5sd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sd6 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Seattle Structural Genomics Center For Infectious Disease (Ssgcid)~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]

OCA at 05:12, 27 January 2022

OCA — Thu, 27 Jan 2022 05:12:08 GMT

←Older revision		Revision as of 05:12, 27 January 2022
Line 5:		Line 5:
	Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

-	Description: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor ~~'EBSI100009'~~	+	Description: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]		[[Category: Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]

OCA: Protected "5sd6" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 11:34:23 GMT

Protected "5sd6" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:34, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 5sd6 is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure of Dihydrofolate Reducta...

OCA — Wed, 29 Dec 2021 11:34:22 GMT

New page: '''Unreleased structure''' The entry 5sd6 is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal Structure of Dihydrofolate Reducta...

New page

'''Unreleased structure'''

The entry 5sd6 is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor 'EBSI100009'
[[Category: Unreleased Structures]]
[[Category: Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]