5sfe - Revision history

OCA at 06:58, 3 April 2024

OCA — Wed, 03 Apr 2024 06:58:15 GMT

←Older revision		Revision as of 06:58, 3 April 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5sfe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SFE FirstGlance]. <br>		<table><tr><td colspan='2'>[[5sfe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SFE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=WP3:N~5~-[(2P,4S)-2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-N~4~,N~4~,1-trimethyl-1H-pyrazole-4,5-dicarboxamide'>WP3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=WP3:N~5~-[(2P,4S)-2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-N~4~,N~4~,1-trimethyl-1H-pyrazole-4,5-dicarboxamide'>WP3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sfe OCA], [https://pdbe.org/5sfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sfe RCSB], [https://www.ebi.ac.uk/pdbsum/5sfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sfe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sfe OCA], [https://pdbe.org/5sfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sfe RCSB], [https://www.ebi.ac.uk/pdbsum/5sfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sfe ProSAT]</span></td></tr>
	</table>		</table>

OCA at 19:18, 19 October 2022

OCA — Wed, 19 Oct 2022 19:18:11 GMT

←Older revision		Revision as of 19:18, 19 October 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 5sfe is ~~ON HOLD until 2024~~-01-21	+	==Crystal Structure of human phosphodiesterase 10 in complex with 3-N-[2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-4-N,4-N,2-trimethylpyrazole-3,4-dicarboxamide==
-		+	<StructureSection load='5sfe' size='340' side='right'caption='[[5sfe]], [[Resolution\|resolution]] 1.86Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5sfe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SFE FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=WP3:N~5~-[(2P,4S)-2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-N~4~,N~4~,1-trimethyl-1H-pyrazole-4,5-dicarboxamide'>WP3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sfe OCA], [https://pdbe.org/5sfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sfe RCSB], [https://www.ebi.ac.uk/pdbsum/5sfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sfe ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Benz J]]
		+	[[Category: Gobbi L]]
		+	[[Category: Joseph C]]
		+	[[Category: Rudolph MG]]
		+	[[Category: Schlatter D]]

OCA at 05:54, 22 June 2022

OCA — Wed, 22 Jun 2022 05:54:52 GMT

←Older revision		Revision as of 05:54, 22 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5sfe is ON HOLD until ~~Jan 21~~ 2024	+	The entry 5sfe is ON HOLD until 2024-01-21

	Authors:		Authors:

OCA at 05:53, 9 February 2022

OCA — Wed, 09 Feb 2022 05:53:03 GMT

←Older revision		Revision as of 05:53, 9 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5sfe is ON HOLD	+	The entry 5sfe is ON HOLD until Jan 21 2024

	Authors:		Authors:

OCA: Protected "5sfe" [edit=sysop:move=sysop]

OCA — Wed, 02 Feb 2022 05:21:21 GMT

Protected "5sfe" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:21, 2 February 2022

OCA: New page: '''Unreleased structure''' The entry 5sfe is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Feb 2022 05:21:20 GMT

New page: '''Unreleased structure''' The entry 5sfe is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5sfe is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]