OCA at 07:01, 3 April 2024

OCA — Wed, 03 Apr 2024 07:01:14 GMT

←Older revision		Revision as of 07:01, 3 April 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 5sj8 is ~~ON HOLD until 2024~~-02-01	+	==Crystal Structure of human phosphodiesterase 10 in complex with 12-methoxy-5-methyl-3-propyl-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene-7-carbonitrile==
-		+	<StructureSection load='5sj8' size='340' side='right'caption='[[5sj8]], [[Resolution\|resolution]] 2.49Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5sj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SJ8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=JYA:(10S)-2-methoxy-7-methyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine-6-carbonitrile'>JYA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sj8 OCA], [https://pdbe.org/5sj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sj8 RCSB], [https://www.ebi.ac.uk/pdbsum/5sj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sj8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Benz J]]
		+	[[Category: Flohr A]]
		+	[[Category: Joseph C]]
		+	[[Category: Rudolph MG]]

OCA at 05:59, 22 June 2022

OCA — Wed, 22 Jun 2022 05:59:33 GMT

←Older revision		Revision as of 05:59, 22 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5sj8 is ON HOLD until ~~Feb 01~~ 2024	+	The entry 5sj8 is ON HOLD until 2024-02-01

	Authors:		Authors:

OCA at 06:18, 23 February 2022

OCA — Wed, 23 Feb 2022 06:18:52 GMT

←Older revision		Revision as of 06:18, 23 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5sj8 is ON HOLD	+	The entry 5sj8 is ON HOLD until Feb 01 2024

	Authors:		Authors:

OCA: Protected "5sj8" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2022 05:58:38 GMT

Protected "5sj8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 9 February 2022

OCA: New page: '''Unreleased structure''' The entry 5sj8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 09 Feb 2022 05:58:37 GMT

New page: '''Unreleased structure''' The entry 5sj8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5sj8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

5sj8 - Revision history

OCA at 07:01, 3 April 2024

OCA at 05:59, 22 June 2022

OCA at 06:18, 23 February 2022

OCA: Protected "5sj8" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 5sj8 is ON HOLD Authors: Description: Category: Unreleased Structures