5sxv - Revision history

OCA at 12:50, 4 October 2023

OCA — Wed, 04 Oct 2023 12:50:33 GMT

←Older revision		Revision as of 12:50, 4 October 2023
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	<StructureSection load='5sxv' size='340' side='right'caption='[[5sxv]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='5sxv' size='340' side='right'caption='[[5sxv]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5sxv]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var.~~ chrysanthemi~~" (burkholder et al. 1953) dye 1969~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5SXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5sxv]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_chrysanthemi Dickeya chrysanthemi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SXV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=BRJ:2~~-~~BROMOETHANOL'>BRJ</scene>~~, ~~<scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5sxu\|5sxu]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRJ:2-BROMOETHANOL'>BRJ</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5sxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sxv OCA], [~~http~~://pdbe.org/5sxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5sxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5sxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5sxv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sxv OCA], [https://pdbe.org/5sxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sxv RCSB], [https://www.ebi.ac.uk/pdbsum/5sxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sxv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ELIC_DICCH ELIC_DICCH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dickeya chrysanthemi]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Q]]	+	[[Category: Chen Q]]
-	[[Category: Cohen, A]]	+	[[Category: Cohen A]]
-	[[Category: Kinde, M]]	+	[[Category: Kinde M]]
-	[[Category: Tang, P]]	+	[[Category: Tang P]]
-	[[Category: Xu, Y]]	+	[[Category: Xu Y]]
-	~~[[Category: Anesthetic]]~~	+
-	~~[[Category: Elic]]~~	+
-	~~[[Category: Ethanol]]~~	+
-	~~[[Category: Resting state]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 12:25, 25 December 2019

OCA — Wed, 25 Dec 2019 12:25:32 GMT

←Older revision		Revision as of 12:25, 25 December 2019
Line 1:		Line 1:

	==X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state==		==X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state==
-	<StructureSection load='5sxv' size='340' side='right' caption='[[5sxv]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='5sxv' size='340' side='right'caption='[[5sxv]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5sxv]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var. chrysanthemi" (burkholder et al. 1953) dye 1969]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[5sxv]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var. chrysanthemi" (burkholder et al. 1953) dye 1969]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SXV FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5sxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5sxv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, Q]]		[[Category: Chen, Q]]
	[[Category: Cohen, A]]		[[Category: Cohen, A]]

OCA at 10:12, 22 November 2017

OCA — Wed, 22 Nov 2017 10:12:47 GMT

←Older revision		Revision as of 10:12, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='5sxv' size='340' side='right' caption='[[5sxv]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='5sxv' size='340' side='right' caption='[[5sxv]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5sxv]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5sxv]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/"erwinia_carotovora_var._chrysanthemi"_(burkholder_et_al._1953)_dye_1969 "erwinia carotovora var. chrysanthemi" (burkholder et al. 1953) dye 1969]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRJ:2-BROMOETHANOL'>BRJ</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRJ:2-BROMOETHANOL'>BRJ</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5sxu\|5sxu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5sxu\|5sxu]]</td></tr>

OCA at 08:59, 16 November 2017

OCA — Thu, 16 Nov 2017 08:59:48 GMT

←Older revision		Revision as of 08:59, 16 November 2017
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5sxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5sxv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:49, 13 September 2017

OCA — Wed, 13 Sep 2017 10:49:34 GMT

←Older revision		Revision as of 10:49, 13 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5sxv is ~~ON HOLD until Paper~~ Publication	+	==X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state==
		+	<StructureSection load='5sxv' size='340' side='right' caption='[[5sxv]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5sxv]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SXV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRJ:2-BROMOETHANOL'>BRJ</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5sxu\|5sxu]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sxv OCA], [http://pdbe.org/5sxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sxv RCSB], [http://www.ebi.ac.uk/pdbsum/5sxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sxv ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structural basis for alcohol modulation of neuronal pentameric ligand-gated ion channels (pLGICs) remains elusive. We determined an inhibitory mechanism of alcohol on the pLGIC Erwinia chrysanthemi (ELIC) through direct binding to the pore. X-ray structures of ELIC co-crystallized with 2-bromoethanol, in both the absence and presence of agonist, reveal 2-bromoethanol binding in the pore near T237(6') and the extracellular domain (ECD) of each subunit at three different locations. Binding to the ECD does not appear to contribute to the inhibitory action of 2-bromoethanol and ethanol as indicated by the same functional responses of wild-type ELIC and mutants. In contrast, the ELIC-alpha1beta3GABAAR chimera, replacing the ELIC transmembrane domain (TMD) with the TMD of alpha1beta3GABAAR, is potentiated by 2-bromoethanol and ethanol. The results suggest a dominant role of the TMD in modulating alcohol effects. The X-ray structures and functional measurements support a pore-blocking mechanism for inhibitory action of short-chain alcohols.

-	~~Authors: Chen~~, Q., ~~Kinde~~, M., ~~Cohen~~, A., Xu, Y., Tang, P.	+	Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.,Chen Q, Wells MM, Tillman TS, Kinde MN, Cohen A, Xu Y, Tang P Structure. 2017 Jan 3;25(1):180-187. doi: 10.1016/j.str.2016.11.007. Epub 2016, Dec 1. PMID:27916519<ref>PMID:27916519</ref>

-	~~Description: X-ray structure~~ of 2-~~bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5sxv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels\|Ion channels]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, Q]]
	[[Category: Cohen, A]]		[[Category: Cohen, A]]
		+	[[Category: Kinde, M]]
	[[Category: Tang, P]]		[[Category: Tang, P]]
	[[Category: Xu, Y]]		[[Category: Xu, Y]]
-	[[Category: ~~Kinde, M~~]]	+	[[Category: Anesthetic]]
-	[[Category: ~~Chen, Q~~]]	+	[[Category: Elic]]
		+	[[Category: Ethanol]]
		+	[[Category: Resting state]]
		+	[[Category: Transport protein]]

OCA at 13:17, 9 March 2017

OCA — Thu, 09 Mar 2017 13:17:24 GMT

←Older revision		Revision as of 13:17, 9 March 2017
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	Description: X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state		Description: X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Cohen, A]]
	[[Category: Tang, P]]		[[Category: Tang, P]]
	[[Category: Xu, Y]]		[[Category: Xu, Y]]
-	[[Category: Cohen, A]]
	[[Category: Kinde, M]]		[[Category: Kinde, M]]
	[[Category: Chen, Q]]		[[Category: Chen, Q]]

OCA: Protected "5sxv" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 15:23:50 GMT

Protected "5sxv" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:23, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5sxv is ON HOLD until Paper Publication Authors: Chen, Q., Kinde, M., Cohen, A., Xu, Y., Tang, P. Description: X-ray structure of 2-bromoethanol bo...

OCA — Fri, 09 Sep 2016 15:23:48 GMT

New page: '''Unreleased structure''' The entry 5sxv is ON HOLD until Paper Publication Authors: Chen, Q., Kinde, M., Cohen, A., Xu, Y., Tang, P. Description: X-ray structure of 2-bromoethanol bo...

New page

'''Unreleased structure'''

The entry 5sxv is ON HOLD until Paper Publication

Authors: Chen, Q., Kinde, M., Cohen, A., Xu, Y., Tang, P.

Description: X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state
[[Category: Unreleased Structures]]
[[Category: Tang, P]]
[[Category: Xu, Y]]
[[Category: Cohen, A]]
[[Category: Kinde, M]]
[[Category: Chen, Q]]