5sy5 - Revision history

OCA at 12:50, 4 October 2023

OCA — Wed, 04 Oct 2023 12:50:38 GMT

←Older revision		Revision as of 12:50, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5sy5' size='340' side='right'caption='[[5sy5]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='5sy5' size='340' side='right'caption='[[5sy5]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5sy5]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5SY5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5sy5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SY5 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Arnt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~, ~~Npas1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.201Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5sy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy5 OCA], [~~http~~://pdbe.org/5sy5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5sy5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5sy5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy5 OCA], [https://pdbe.org/5sy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sy5 RCSB], [https://www.ebi.ac.uk/pdbsum/5sy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). [[http://www.uniprot.org/uniprot/NPAS1_MOUSE NPAS1_MOUSE]] May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.<ref>PMID:15347806</ref> <ref>PMID:15635607</ref>	+	[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5sy5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5sy5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of hypoxia-inducible factor\|3D structures of hypoxia-inducible factor]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	[[Category: Potluri, N]]	+	[[Category: Potluri N]]
-	[[Category: Rastinejad, F]]	+	[[Category: Rastinejad F]]
-	[[Category: Su, X]]	+	[[Category: Su X]]
-	[[Category: Wu, D]]	+	[[Category: Wu D]]
-	~~[[Category: Bhlh-pas protein]]~~	+
-	~~[[Category: Heterodimeric complex]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 11:14, 16 September 2020

OCA — Wed, 16 Sep 2020 11:14:09 GMT

←Older revision		Revision as of 11:14, 16 September 2020
Line 1:		Line 1:

	==Crystal Structure of the Heterodimeric NPAS1-ARNT Complex==		==Crystal Structure of the Heterodimeric NPAS1-ARNT Complex==
-	<StructureSection load='5sy5' size='340' side='right' caption='[[5sy5]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='5sy5' size='340' side='right'caption='[[5sy5]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5sy5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5SY5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5sy5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5SY5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5sy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy5 OCA], [http://pdbe.org/5sy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sy5 RCSB], [http://www.ebi.ac.uk/pdbsum/5sy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy5 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arnt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Npas1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5sy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy5 OCA], [http://pdbe.org/5sy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sy5 RCSB], [http://www.ebi.ac.uk/pdbsum/5sy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Kim, Y]]		[[Category: Kim, Y]]
	[[Category: Potluri, N]]		[[Category: Potluri, N]]

OCA at 19:58, 9 December 2016

OCA — Fri, 09 Dec 2016 19:58:11 GMT

←Older revision		Revision as of 19:58, 9 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5sy5 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal Structure of the Heterodimeric NPAS1-ARNT Complex==
		+	<StructureSection load='5sy5' size='340' side='right' caption='[[5sy5]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5sy5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SY5 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sy5 OCA], [http://pdbe.org/5sy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sy5 RCSB], [http://www.ebi.ac.uk/pdbsum/5sy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sy5 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). [[http://www.uniprot.org/uniprot/NPAS1_MOUSE NPAS1_MOUSE]] May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.<ref>PMID:15347806</ref> <ref>PMID:15635607</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 must each heterodimerize with the aryl hydrocarbon receptor nuclear translocator (ARNT), to form functional transcription complexes capable of DNA binding and gene regulation. Here we examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. Through expanded architectural comparisons between these complexes and HIF-1alpha-ARNT, HIF-2alpha-ARNT and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and presents as an ideal class of transcription factors for direct targeting by small-molecule drugs.

-	~~Authors: Wu~~, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F.	+	NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.,Wu D, Su X, Potluri N, Kim Y, Rastinejad F Elife. 2016 Oct 26;5. pii: e18790. doi: 10.7554/eLife.18790. PMID:27782878<ref>PMID:27782878</ref>

-	~~Description: Crystal Structure~~ of the ~~Heterodimeric NPAS1-ARNT Complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Su, X]]	+	<div class="pdbe-citations 5sy5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kim, Y]]
	[[Category: Potluri, N]]		[[Category: Potluri, N]]
	[[Category: Rastinejad, F]]		[[Category: Rastinejad, F]]
		+	[[Category: Su, X]]
	[[Category: Wu, D]]		[[Category: Wu, D]]
-	[[Category: ~~Kim, Y~~]]	+	[[Category: Bhlh-pas protein]]
		+	[[Category: Heterodimeric complex]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]

OCA: Protected "5sy5" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 15:24:41 GMT

Protected "5sy5" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:24, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5sy5 is ON HOLD until Paper Publication Authors: Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F. Description: Crystal Structure of the Heterod...

OCA — Fri, 09 Sep 2016 15:24:40 GMT

New page: '''Unreleased structure''' The entry 5sy5 is ON HOLD until Paper Publication Authors: Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F. Description: Crystal Structure of the Heterod...

New page

'''Unreleased structure'''

The entry 5sy5 is ON HOLD until Paper Publication

Authors: Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F.

Description: Crystal Structure of the Heterodimeric NPAS1-ARNT Complex
[[Category: Unreleased Structures]]
[[Category: Su, X]]
[[Category: Potluri, N]]
[[Category: Rastinejad, F]]
[[Category: Wu, D]]
[[Category: Kim, Y]]