5szq - Revision history

OCA at 12:52, 4 October 2023

OCA — Wed, 04 Oct 2023 12:52:09 GMT

←Older revision		Revision as of 12:52, 4 October 2023
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	<StructureSection load='5szq' size='340' side='right'caption='[[5szq]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='5szq' size='340' side='right'caption='[[5szq]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5szq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SZQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5SZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5szq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SZQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.608Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5szr\|5szr]], [[5szp\|5szp]], [[5szo\|5szo]], [[5szn\|5szn]], [[5szm\|5szm]], [[5szl\|5szl]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pcdhga4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5szq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5szq OCA], [https://pdbe.org/5szq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5szq RCSB], [https://www.ebi.ac.uk/pdbsum/5szq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5szq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5szq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5szq OCA], [~~http~~://pdbe.org/5szq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5szq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5szq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5szq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCDG4_MOUSE PCDG4_MOUSE]] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity).[UniProtKB:Q9Y5H4]	+	[https://www.uniprot.org/uniprot/PCDG4_MOUSE PCDG4_MOUSE] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity).[UniProtKB:Q9Y5H4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bahna, F]]	+	[[Category: Bahna F]]
-	[[Category: Goodman~~, K M~~]]	+	[[Category: Goodman KM]]
-	[[Category: Honig, B]]	+	[[Category: Honig B]]
-	[[Category: Mannepalli, S]]	+	[[Category: Mannepalli S]]
-	[[Category: Shapiro, L]]	+	[[Category: Shapiro L]]
-	~~[[Category: Cell adhesion~~]]	+

OCA at 11:15, 16 September 2020

OCA — Wed, 16 Sep 2020 11:15:44 GMT

←Older revision		Revision as of 11:15, 16 September 2020
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	==Protocadherin Gamma A4 extracellular cadherin domains 3-6==		==Protocadherin Gamma A4 extracellular cadherin domains 3-6==
-	<StructureSection load='5szq' size='340' side='right' caption='[[5szq]], [[Resolution\|resolution]] 2.61Å' scene=''>	+	<StructureSection load='5szq' size='340' side='right'caption='[[5szq]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5szq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SZQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5SZQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5szq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SZQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5SZQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5szr\|5szr]], [[5szp\|5szp]], [[5szo\|5szo]], [[5szn\|5szn]], [[5szm\|5szm]], [[5szl\|5szl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5szr\|5szr]], [[5szp\|5szp]], [[5szo\|5szo]], [[5szn\|5szn]], [[5szm\|5szm]], [[5szl\|5szl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5szq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5szq OCA], [http://pdbe.org/5szq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5szq RCSB], [http://www.ebi.ac.uk/pdbsum/5szq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5szq ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pcdhga4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5szq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5szq OCA], [http://pdbe.org/5szq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5szq RCSB], [http://www.ebi.ac.uk/pdbsum/5szq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5szq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Bahna, F]]		[[Category: Bahna, F]]
	[[Category: Goodman, K M]]		[[Category: Goodman, K M]]

OCA at 20:09, 9 December 2016

OCA — Fri, 09 Dec 2016 20:09:42 GMT

←Older revision		Revision as of 20:09, 9 December 2016
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PCDG4_MOUSE PCDG4_MOUSE]] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity).[UniProtKB:Q9Y5H4]		[[http://www.uniprot.org/uniprot/PCDG4_MOUSE PCDG4_MOUSE]] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity).[UniProtKB:Q9Y5H4]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Stochastic cell-surface expression of alpha-, beta-, and gamma-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie neuronal self-recognition. Here we report crystal structures of ectodomain fragments comprising cell-cell recognition regions of mouse gamma-Pcdhs gammaA1, gammaA8, gammaB2, and gammaB7 revealing trans-homodimers, and of C-terminal ectodomain fragments from gamma-Pcdhs gammaA4 and gammaB2, which depict cis-interacting regions in monomeric form. Together these structures span the entire gamma-Pcdh ectodomain. The trans-dimer structures reveal determinants of gamma-Pcdh isoform-specific homophilic recognition. We identified and structurally mapped cis-dimerization mutations to the C-terminal ectodomain structures. Biophysical studies showed that Pcdh ectodomains from gammaB-subfamily isoforms formed cis dimers, whereas gammaA isoforms did not, but both gammaA and gammaB isoforms could interact in cis with alpha-Pcdhs. Together, these data show how interaction specificity is distributed over all domains of the gamma-Pcdh trans interface, and suggest that subfamily- or isoform-specific cis-interactions may play a role in the Pcdh-mediated neuronal self-recognition code.
		+
		+	gamma-Protocadherin structural diversity and functional implications.,Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsen G, Rittenhouse C, Maniatis T, Honig B, Shapiro L Elife. 2016 Oct 26;5. pii: e20930. doi: 10.7554/eLife.20930. PMID:27782885<ref>PMID:27782885</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5szq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:32, 2 November 2016

OCA — Wed, 02 Nov 2016 18:32:09 GMT

←Older revision		Revision as of 18:32, 2 November 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5szq is ~~ON HOLD until Paper Publication~~	+	==Protocadherin Gamma A4 extracellular cadherin domains 3-6==
-		+	<StructureSection load='5szq' size='340' side='right' caption='[[5szq]], [[Resolution\|resolution]] 2.61Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5szq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SZQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5szr\|5szr]], [[5szp\|5szp]], [[5szo\|5szo]], [[5szn\|5szn]], [[5szm\|5szm]], [[5szl\|5szl]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5szq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5szq OCA], [http://pdbe.org/5szq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5szq RCSB], [http://www.ebi.ac.uk/pdbsum/5szq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5szq ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCDG4_MOUSE PCDG4_MOUSE]] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity).[UniProtKB:Q9Y5H4]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bahna, F]]
		+	[[Category: Goodman, K M]]
		+	[[Category: Honig, B]]
		+	[[Category: Mannepalli, S]]
		+	[[Category: Shapiro, L]]
		+	[[Category: Cell adhesion]]

OCA at 12:04, 21 September 2016

OCA — Wed, 21 Sep 2016 12:04:09 GMT

←Older revision		Revision as of 12:04, 21 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5szq is ON HOLD	+	The entry 5szq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5szq" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 15:27:52 GMT

Protected "5szq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:27, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5szq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 09 Sep 2016 15:27:51 GMT

New page: '''Unreleased structure''' The entry 5szq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5szq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]