5t96 - Revision history

OCA at 12:56, 4 October 2023

OCA — Wed, 04 Oct 2023 12:56:47 GMT

←Older revision		Revision as of 12:56, 4 October 2023
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	<StructureSection load='5t96' size='340' side='right'caption='[[5t96]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5t96' size='340' side='right'caption='[[5t96]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5t96]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Isav Isav~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T96 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5T96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5t96]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmon_isavirus Salmon isavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T96 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=79J:4-O-ACETYL-5-(ACETYLAMINO)-3,5-DIDEOXY-L-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>79J</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5t9y\|5t9y]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=79J:4-O-ACETYL-5-(ACETYLAMINO)-3,5-DIDEOXY-L-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>79J</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=55987 ISAV])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t96 OCA], [https://pdbe.org/5t96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t96 RCSB], [https://www.ebi.ac.uk/pdbsum/5t96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t96 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t96 OCA], [~~http~~://pdbe.org/5t96 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5t96 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5t96 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5t96 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9J0Y0_9ORTO Q9J0Y0_9ORTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Isav]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cook, J D~~]]	+	[[Category: Salmon isavirus]]
-	[[Category: ~~Lee, J E~~]]	+	[[Category: Cook JD]]
-	[[Category: ~~Sultana, A~~]]	+	[[Category: Lee JE]]
-	[[Category: ~~4-0-acetylsialic acid]]~~	+	[[Category: Sultana A]]
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Infectious salmon anemia virus]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Viral receptor-complex~~]]	+

OCA at 11:27, 16 September 2020

OCA — Wed, 16 Sep 2020 11:27:08 GMT

←Older revision		Revision as of 11:27, 16 September 2020
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	==Crystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complex==		==Crystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complex==
-	<StructureSection load='5t96' size='340' side='right' caption='[[5t96]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5t96' size='340' side='right'caption='[[5t96]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5t96]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T96 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5T96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5t96]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Isav Isav]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T96 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5T96 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=79J:4-O-ACETYL-5-(ACETYLAMINO)-3,5-DIDEOXY-L-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>79J</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=79J:4-O-ACETYL-5-(ACETYLAMINO)-3,5-DIDEOXY-L-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>79J</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5t9y\|5t9y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5t9y\|5t9y]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t96 OCA], [http://pdbe.org/5t96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t96 RCSB], [http://www.ebi.ac.uk/pdbsum/5t96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t96 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=55987 ISAV])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t96 OCA], [http://pdbe.org/5t96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t96 RCSB], [http://www.ebi.ac.uk/pdbsum/5t96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t96 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5t96" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5t96" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin-esterase 3D structures\|Hemagglutinin-esterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Isav]]
		+	[[Category: Large Structures]]
	[[Category: Cook, J D]]		[[Category: Cook, J D]]
	[[Category: Lee, J E]]		[[Category: Lee, J E]]
Line 29:		Line 35:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Infectious salmon anemia virus]]		[[Category: Infectious salmon anemia virus]]
-	[[Category: Isav]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Viral receptor-complex]]		[[Category: Viral receptor-complex]]

OCA at 06:52, 5 April 2017

OCA — Wed, 05 Apr 2017 06:52:41 GMT

←Older revision		Revision as of 06:52, 5 April 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t96 OCA], [http://pdbe.org/5t96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t96 RCSB], [http://www.ebi.ac.uk/pdbsum/5t96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t96 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t96 OCA], [http://pdbe.org/5t96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t96 RCSB], [http://www.ebi.ac.uk/pdbsum/5t96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t96 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Orthomyxoviruses are an important family of RNA viruses, which include the various influenza viruses. Despite global efforts to eradicate orthomyxoviral pathogens, these infections remain pervasive. One such orthomyxovirus, infectious salmon anemia virus (ISAV), spreads easily throughout farmed and wild salmonids, constituting a significant economic burden. ISAV entry requires the interplay of the virion-attached hemagglutinin-esterase and fusion glycoproteins. Preventing infections will rely on improved understanding of ISAV entry. Here, we present the crystal structures of ISAV hemagglutinin-esterase unbound and complexed with receptor. Several distinctive features observed in ISAV HE are not seen in any other viral glycoprotein. The structures reveal a unique mode of receptor binding that is dependent on the oligomeric assembly of hemagglutinin-esterase. Importantly, ISAV hemagglutinin-esterase receptor engagement does not initiate conformational rearrangements, suggesting a distinct viral entry mechanism. This work improves our understanding of ISAV pathogenesis and expands our knowledge on the overall diversity of viral glycoprotein-mediated entry mechanisms. Finally, it provides an atomic-resolution model of the primary neutralizing antigen critical for vaccine development.
		+
		+	Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment.,Cook JD, Sultana A, Lee JE Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201617993. doi:, 10.1073/pnas.1617993114. PMID:28320973<ref>PMID:28320973</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5t96" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:44, 22 March 2017

OCA — Wed, 22 Mar 2017 16:44:58 GMT

←Older revision		Revision as of 16:44, 22 March 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5t96 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complex==
-		+	<StructureSection load='5t96' size='340' side='right' caption='[[5t96]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5t96]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T96 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=79J:4-O-ACETYL-5-(ACETYLAMINO)-3,5-DIDEOXY-L-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>79J</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5t9y\|5t9y]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t96 OCA], [http://pdbe.org/5t96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t96 RCSB], [http://www.ebi.ac.uk/pdbsum/5t96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t96 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cook, J D]]
		+	[[Category: Lee, J E]]
		+	[[Category: Sultana, A]]
		+	[[Category: 4-0-acetylsialic acid]]
		+	[[Category: Coiled-coil]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Hydrolase]]
		+	[[Category: Infectious salmon anemia virus]]
		+	[[Category: Isav]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral receptor-complex]]

OCA at 17:20, 9 December 2016

OCA — Fri, 09 Dec 2016 17:20:07 GMT

←Older revision		Revision as of 17:20, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5t96 is ON HOLD	+	The entry 5t96 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 16:30, 2 November 2016

OCA — Wed, 02 Nov 2016 16:30:51 GMT

←Older revision		Revision as of 16:30, 2 November 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5t96 is ON HOLD ~~until Paper Publication~~	+	The entry 5t96 is ON HOLD

	Authors:		Authors:

OCA at 15:34, 19 October 2016

OCA — Wed, 19 Oct 2016 15:34:14 GMT

←Older revision		Revision as of 15:34, 19 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5t96 is ON HOLD	+	The entry 5t96 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5t96" [edit=sysop:move=sysop]

OCA — Wed, 21 Sep 2016 12:22:23 GMT

Protected "5t96" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:22, 21 September 2016

OCA: New page: '''Unreleased structure''' The entry 5t96 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Sep 2016 12:22:22 GMT

New page: '''Unreleased structure''' The entry 5t96 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5t96 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]