5te5 - Revision history

OCA at 12:58, 4 October 2023

OCA — Wed, 04 Oct 2023 12:58:32 GMT

←Older revision		Revision as of 12:58, 4 October 2023
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	<StructureSection load='5te5' size='340' side='right'caption='[[5te5]], [[Resolution\|resolution]] 4.01Å' scene=''>		<StructureSection load='5te5' size='340' side='right'caption='[[5te5]], [[Resolution\|resolution]] 4.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5te5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TE5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TE5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5te5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TE5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7AB:(2E)-{(4E)-4-[(3E)-4-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)BUT-3-EN-2-YLIDENE]CYCLOHEX-2-EN-1-YLIDENE}ACETALDEHYDE'>7AB</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.01Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7AB:(2E)-{(4E)-4-[(3E)-4-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)BUT-3-EN-2-YLIDENE]CYCLOHEX-2-EN-1-YLIDENE}ACETALDEHYDE'>7AB</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5te3\|5te3]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5te5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5te5 OCA], [https://pdbe.org/5te5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5te5 RCSB], [https://www.ebi.ac.uk/pdbsum/5te5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5te5 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5te5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5te5 OCA], [~~http~~://pdbe.org/5te5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5te5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5te5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5te5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>	+	[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Banerjee, S]]	+	[[Category: Banerjee S]]
-	[[Category: Gulati, S]]	+	[[Category: Gulati S]]
-	[[Category: Katayama, K]]	+	[[Category: Katayama K]]
-	[[Category: Kiser~~, P D~~]]	+	[[Category: Kiser PD]]
-	[[Category: Palczewski, K]]	+	[[Category: Palczewski K]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 11:30, 16 September 2020

OCA — Wed, 16 Sep 2020 11:30:52 GMT

←Older revision		Revision as of 11:30, 16 September 2020
Line 1:		Line 1:

	==Crystal structure of Bos taurus opsin regenerated with 6-carbon ring retinal chromophore==		==Crystal structure of Bos taurus opsin regenerated with 6-carbon ring retinal chromophore==
-	<StructureSection load='5te5' size='340' side='right' caption='[[5te5]], [[Resolution\|resolution]] 4.01Å' scene=''>	+	<StructureSection load='5te5' size='340' side='right'caption='[[5te5]], [[Resolution\|resolution]] 4.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5te5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TE5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TE5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5te5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TE5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TE5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7AB:(2E)-{(4E)-4-[(3E)-4-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)BUT-3-EN-2-YLIDENE]CYCLOHEX-2-EN-1-YLIDENE}ACETALDEHYDE'>7AB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7AB:(2E)-{(4E)-4-[(3E)-4-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)BUT-3-EN-2-YLIDENE]CYCLOHEX-2-EN-1-YLIDENE}ACETALDEHYDE'>7AB</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5te3\|5te3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5te3\|5te3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5te5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5te5 OCA], [http://pdbe.org/5te5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5te5 RCSB], [http://www.ebi.ac.uk/pdbsum/5te5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5te5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5te5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5te5 OCA], [http://pdbe.org/5te5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5te5 RCSB], [http://www.ebi.ac.uk/pdbsum/5te5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5te5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5te5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5te5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rhodopsin 3D structures\|Rhodopsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Banerjee, S]]		[[Category: Banerjee, S]]
	[[Category: Gulati, S]]		[[Category: Gulati, S]]

OCA at 06:52, 29 March 2017

OCA — Wed, 29 Mar 2017 06:52:12 GMT

←Older revision		Revision as of 06:52, 29 March 2017
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>		[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vertebrate rhodopsin (Rh) contains 11-cis-retinal as a chromophore to convert light energy into visual signals. On absorption of light, 11-cis-retinal is isomerized to all-trans-retinal, constituting a one-way reaction that activates transducin (Gt) followed by chromophore release. Here we report that bovine Rh, regenerated instead with a six-carbon-ring retinal chromophore featuring a C11=C12 double bond locked in its cis conformation (Rh6mr), employs an atypical isomerization mechanism by converting 11-cis to an 11,13-dicis configuration for prolonged Gt activation. Time-dependent UV-vis spectroscopy, HPLC, and molecular mechanics analyses revealed an atypical thermal reisomerization of the 11,13-dicis to the 11-cis configuration on a slow timescale, which enables Rh6mr to function in a photocyclic manner similar to that of microbial Rhs. With this photocyclic behavior, Rh6mr repeatedly recruits and activates Gt in response to light stimuli, making it an excellent candidate for optogenetic tools based on retinal analog-bound vertebrate Rhs. Overall, these comprehensive structure-function studies unveil a unique photocyclic mechanism of Rh activation by an 11-cis-to-11,13-dicis isomerization.
		+
		+	Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.,Gulati S, Jastrzebska B, Banerjee S, Placeres AL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K Proc Natl Acad Sci U S A. 2017 Mar 13. pii: 201617446. doi:, 10.1073/pnas.1617446114. PMID:28289214<ref>PMID:28289214</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5te5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:46, 15 March 2017

OCA — Wed, 15 Mar 2017 21:46:48 GMT

←Older revision		Revision as of 21:46, 15 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5te5 is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of Bos taurus opsin regenerated with 6-carbon ring retinal chromophore==
-		+	<StructureSection load='5te5' size='340' side='right' caption='[[5te5]], [[Resolution\|resolution]] 4.01Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5te5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TE5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7AB:(2E)-{(4E)-4-[(3E)-4-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)BUT-3-EN-2-YLIDENE]CYCLOHEX-2-EN-1-YLIDENE}ACETALDEHYDE'>7AB</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5te3\|5te3]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5te5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5te5 OCA], [http://pdbe.org/5te5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5te5 RCSB], [http://www.ebi.ac.uk/pdbsum/5te5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5te5 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Banerjee, S]]
		+	[[Category: Gulati, S]]
		+	[[Category: Katayama, K]]
		+	[[Category: Kiser, P D]]
		+	[[Category: Palczewski, K]]
		+	[[Category: Signaling protein]]

OCA at 17:26, 9 December 2016

OCA — Fri, 09 Dec 2016 17:26:31 GMT

←Older revision		Revision as of 17:26, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5te5 is ON HOLD	+	The entry 5te5 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5te5" [edit=sysop:move=sysop]

OCA — Mon, 03 Oct 2016 15:32:25 GMT

Protected "5te5" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:32, 3 October 2016

OCA: New page: '''Unreleased structure''' The entry 5te5 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Mon, 03 Oct 2016 15:32:23 GMT

New page: '''Unreleased structure''' The entry 5te5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5te5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]