5tg4 - Revision history

OCA at 13:00, 4 October 2023

OCA — Wed, 04 Oct 2023 13:00:03 GMT

←Older revision		Revision as of 13:00, 4 October 2023
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	<StructureSection load='5tg4' size='340' side='right'caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>		<StructureSection load='5tg4' size='340' side='right'caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aciba Aciba~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=3GR:GLYCERALDEHYDE'>3GR</scene>~~, ~~<scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=JW1:{3-~~[~~(TERT-BUTOXYCARBONYL)AMINO~~]~~PHENYL}BORONIC+ACID'>JW1</scene>, <scene name='pdbligand=MEE:METHANETHIOL'>MEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.44Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~ABA~~:~~ALPHA-AMINOBUTYRIC+ACID~~'>~~ABA~~</scene>, <scene name='pdbligand=~~KCX~~:~~LYSINE+NZ~~-~~CARBOXYLIC~~+ACID'>~~KCX~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3GR:GLYCERALDEHYDE'>3GR</scene>, <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=JW1:{3-[(TERT-BUTOXYCARBONYL)AMINO]PHENYL}BORONIC+ACID'>JW1</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MEE:METHANETHIOL'>MEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">~~[~~[5tg5\|5tg5~~]~~], [[5tg6\|5tg6]], [[5tg7\|5tg7]]</td~~></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tg4 OCA], [https://pdbe.org/5tg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tg4 RCSB], [https://www.ebi.ac.uk/pdbsum/5tg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tg4 ProSAT]</span></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">blaOXA-33~~, ~~bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tg4 OCA], [~~http~~://pdbe.org/5tg4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tg4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tg4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tg4 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8RLA6_ACIBA Q8RLA6_ACIBA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aciba]]~~	+	[[Category: Acinetobacter baumannii]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mitchell~~, J M~~]]	+	[[Category: Mitchell JM]]
-	[[Category: Powers~~, R A~~]]	+	[[Category: Powers RA]]
-	[[Category: Werner~~, J P]]~~	+	[[Category: Werner JP]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Lactamase]]~~	+
-	~~[[Category: Oxa~~]]	+

OCA at 14:26, 8 July 2020

OCA — Wed, 08 Jul 2020 14:26:49 GMT

←Older revision		Revision as of 14:26, 8 July 2020
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	<StructureSection load='5tg4' size='340' side='right'caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>		<StructureSection load='5tg4' size='340' side='right'caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3GR:GLYCERALDEHYDE'>3GR</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=JW1:{3-[(TERT-BUTOXYCARBONYL)AMINO]PHENYL}BORONIC+ACID'>JW1</scene>, <scene name='pdbligand=MEE:METHANETHIOL'>MEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3GR:GLYCERALDEHYDE'>3GR</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=JW1:{3-[(TERT-BUTOXYCARBONYL)AMINO]PHENYL}BORONIC+ACID'>JW1</scene>, <scene name='pdbligand=MEE:METHANETHIOL'>MEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tg5\|5tg5]], [[5tg6\|5tg6]], [[5tg7\|5tg7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tg5\|5tg5]], [[5tg6\|5tg6]], [[5tg7\|5tg7]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-33, bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-33, bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tg4 OCA], [http://pdbe.org/5tg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5tg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tg4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tg4 OCA], [http://pdbe.org/5tg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5tg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tg4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:55, 11 December 2019

OCA — Wed, 11 Dec 2019 16:55:28 GMT

←Older revision		Revision as of 16:55, 11 December 2019
Line 1:		Line 1:

	==OXA-24/40 in Complex with Boronic Acid BA16==		==OXA-24/40 in Complex with Boronic Acid BA16==
-	<StructureSection load='5tg4' size='340' side='right' caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>	+	<StructureSection load='5tg4' size='340' side='right'caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5tg4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tg4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	[[Category: Aciba]]		[[Category: Aciba]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Mitchell, J M]]		[[Category: Mitchell, J M]]
	[[Category: Powers, R A]]		[[Category: Powers, R A]]

OCA at 19:07, 15 November 2017

OCA — Wed, 15 Nov 2017 19:07:13 GMT

←Older revision		Revision as of 19:07, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5tg4' size='340' side='right' caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>		<StructureSection load='5tg4' size='340' side='right' caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3GR:GLYCERALDEHYDE'>3GR</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=JW1:{3-[(TERT-BUTOXYCARBONYL)AMINO]PHENYL}BORONIC+ACID'>JW1</scene>, <scene name='pdbligand=MEE:METHANETHIOL'>MEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3GR:GLYCERALDEHYDE'>3GR</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=JW1:{3-[(TERT-BUTOXYCARBONYL)AMINO]PHENYL}BORONIC+ACID'>JW1</scene>, <scene name='pdbligand=MEE:METHANETHIOL'>MEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tg5\|5tg5]], [[5tg6\|5tg6]], [[5tg7\|5tg7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tg5\|5tg5]], [[5tg6\|5tg6]], [[5tg7\|5tg7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-33, bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tg4 OCA], [http://pdbe.org/5tg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5tg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tg4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tg4 OCA], [http://pdbe.org/5tg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5tg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tg4 ProSAT]</span></td></tr>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aciba]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Mitchell, J M]]		[[Category: Mitchell, J M]]

OCA at 16:38, 18 January 2017

OCA — Wed, 18 Jan 2017 16:38:49 GMT

←Older revision		Revision as of 16:38, 18 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tg4 is ~~ON HOLD until Paper~~ Publication	+	==OXA-24/40 in Complex with Boronic Acid BA16==
		+	<StructureSection load='5tg4' size='340' side='right' caption='[[5tg4]], [[Resolution\|resolution]] 1.44Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tg4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TG4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3GR:GLYCERALDEHYDE'>3GR</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=JW1:{3-[(TERT-BUTOXYCARBONYL)AMINO]PHENYL}BORONIC+ACID'>JW1</scene>, <scene name='pdbligand=MEE:METHANETHIOL'>MEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tg5\|5tg5]], [[5tg6\|5tg6]], [[5tg7\|5tg7]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tg4 OCA], [http://pdbe.org/5tg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5tg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tg4 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-lactam antibiotics are crucial to the management of bacterial infections in the medical community. Due to overuse and misuse, clinically significant bacteria are now resistant to many commercially available antibiotics. The most widespread resistance mechanism to beta-lactams is the expression of beta-lactamase enzymes. To overcome beta-lactamase mediated resistance, inhibitors were designed to inactivate these enzymes. However, current inhibitors (clavulanic acid, tazobactam, and sulbactam) for beta-lactamases also contain the characteristic beta-lactam ring, making them susceptible to resistance mechanisms employed by bacteria. This presents a critical need for novel, non-beta-lactam inhibitors that can circumvent these resistance mechanisms. The carbapenem-hydrolyzing class D beta-lactamases (CHDLs) are of particular concern, given that they efficiently hydrolyze potent carbapenem antibiotics. Unfortunately, these enzymes are not inhibited by clinically available beta-lactamase inhibitors, nor are they effectively inhibited by the newest, non-beta-lactam inhibitor, avibactam. Boronic acids are known transition state analog inhibitors of class A and C beta-lactamases, and are not extensively characterized as inhibitors of class D beta-lactamases. Importantly, boronic acids provide a novel way to potentially inhibit class D beta-lactamases. Sixteen boronic acids were selected and tested for inhibition of the CHDL OXA-24/40. Several compounds were identified as effective inhibitors of OXA-24/40, with Ki values as low as 5 muM. The X-ray crystal structures of OXA-24/40 in complex with BA3, BA4, BA8, and BA16 were determined and revealed the importance of interactions with hydrophobic residues Tyr112 and Trp115. These boronic acids serve as progenitors in optimization efforts of a novel series of inhibitors for class D beta-lactamases. This article is protected by copyright. All rights reserved.

-	~~Authors: Powers, R.A~~., Werner~~, J.P.~~, Mitchell, J.M.	+	Exploring the potential of boronic acids as inhibitors of OXA-24/40 beta-lactamase.,Werner JP, Mitchell JM, Taracila MA, Bonomo RA, Powers RA Protein Sci. 2016 Dec 20. doi: 10.1002/pro.3100. PMID:27997706<ref>PMID:27997706</ref>

-	~~Description: OXA~~-24/~~40 in Complex with Boronic Acid BA16~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Mitchell, J.M]]	+	<div class="pdbe-citations 5tg4" style="background-color:#fffaf0;"></div>
-	[[Category: Werner, J.P]]	+	== References ==
-	[[Category: ~~Powers, R.A~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Mitchell, J M]]
		+	[[Category: Powers, R A]]
		+	[[Category: Werner, J P]]
		+	[[Category: Complex]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Lactamase]]
		+	[[Category: Oxa]]

OCA at 15:46, 19 October 2016

OCA — Wed, 19 Oct 2016 15:46:05 GMT

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-	The entry 5tg4 is ON HOLD	+	The entry 5tg4 is ON HOLD until Paper Publication

	Authors: Powers, R.A., Werner, J.P., Mitchell, J.M.		Authors: Powers, R.A., Werner, J.P., Mitchell, J.M.

OCA: Protected "5tg4" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2016 20:02:38 GMT

Protected "5tg4" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:02, 5 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tg4 is ON HOLD Authors: Powers, R.A., Werner, J.P., Mitchell, J.M. Description: OXA-24/40 in Complex with Boronic Acid BA16 [[Category: Unreleased...

OCA — Wed, 05 Oct 2016 20:02:36 GMT

New page: '''Unreleased structure''' The entry 5tg4 is ON HOLD Authors: Powers, R.A., Werner, J.P., Mitchell, J.M. Description: OXA-24/40 in Complex with Boronic Acid BA16 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 5tg4 is ON HOLD

Authors: Powers, R.A., Werner, J.P., Mitchell, J.M.

Description: OXA-24/40 in Complex with Boronic Acid BA16
[[Category: Unreleased Structures]]
[[Category: Mitchell, J.M]]
[[Category: Werner, J.P]]
[[Category: Powers, R.A]]