5tio - Revision history

OCA at 13:02, 4 October 2023

OCA — Wed, 04 Oct 2023 13:02:48 GMT

←Older revision		Revision as of 13:02, 4 October 2023
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	==Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607==		==Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607==
-	<StructureSection load='5tio' size='340' side='right' caption='[[5tio]], [[Resolution\|resolution]] 3.25Å' scene=''>	+	<StructureSection load='5tio' size='340' side='right'caption='[[5tio]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tio]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TIO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tio]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TIO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7C6:(3S,3AS,9BS)-2-[(2H-1,3-BENZODIOXOL-5-YL)SULFONYL]-3,5-DIMETHYL-1,2,3,3A,5,9B-HEXAHYDRO-4H-PYRROLO[3,4-C][1,6]NAPHTHYRIDIN-4-ONE'>7C6</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tin\|5tin]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7C6:(3S,3AS,9BS)-2-[(2H-1,3-BENZODIOXOL-5-YL)SULFONYL]-3,5-DIMETHYL-1,2,3,3A,5,9B-HEXAHYDRO-4H-PYRROLO[3,4-C][1,6]NAPHTHYRIDIN-4-ONE'>7C6</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tio OCA], [https://pdbe.org/5tio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tio RCSB], [https://www.ebi.ac.uk/pdbsum/5tio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tio ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tio OCA], [~~http~~://pdbe.org/5tio PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tio RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tio PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tio ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN]] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).	+	[https://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Chen, H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Huang, X~~]]	+	[[Category: Chen H]]
-	[[Category: ~~Shaffer, P L~~]]	+	[[Category: Huang X]]
-	[[Category: ~~Ligand-gated ion channel neurotransmitter receptor membrane protein cys-loop receptor]]~~	+	[[Category: Shaffer PL]]
-	~~[[Category: Transport protein~~]]	+

OCA at 10:14, 22 November 2017

OCA — Wed, 22 Nov 2017 10:14:44 GMT

←Older revision		Revision as of 10:14, 22 November 2017
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	<StructureSection load='5tio' size='340' side='right' caption='[[5tio]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='5tio' size='340' side='right' caption='[[5tio]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tio]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tio]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7C6:(3S,3AS,9BS)-2-[(2H-1,3-BENZODIOXOL-5-YL)SULFONYL]-3,5-DIMETHYL-1,2,3,3A,5,9B-HEXAHYDRO-4H-PYRROLO[3,4-C][1,6]NAPHTHYRIDIN-4-ONE'>7C6</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7C6:(3S,3AS,9BS)-2-[(2H-1,3-BENZODIOXOL-5-YL)SULFONYL]-3,5-DIMETHYL-1,2,3,3A,5,9B-HEXAHYDRO-4H-PYRROLO[3,4-C][1,6]NAPHTHYRIDIN-4-ONE'>7C6</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tin\|5tin]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tin\|5tin]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tio OCA], [http://pdbe.org/5tio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tio RCSB], [http://www.ebi.ac.uk/pdbsum/5tio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tio ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tio OCA], [http://pdbe.org/5tio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tio RCSB], [http://www.ebi.ac.uk/pdbsum/5tio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tio ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chen, H]]		[[Category: Chen, H]]
	[[Category: Huang, X]]		[[Category: Huang, X]]

OCA at 00:48, 19 January 2017

OCA — Thu, 19 Jan 2017 00:48:22 GMT

←Older revision		Revision as of 00:48, 19 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tio is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607==
-		+	<StructureSection load='5tio' size='340' side='right' caption='[[5tio]], [[Resolution\|resolution]] 3.25Å' scene=''>
-	~~Authors~~: ~~Shaffer~~, P.L., ~~Huang~~, X., ~~Chen~~, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5tio]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIO FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Human Glycine Receptor alpha~~-~~3 Bound~~ to ~~AM-3607~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7C6:(3S,3AS,9BS)-2-[(2H-1,3-BENZODIOXOL-5-YL)SULFONYL]-3,5-DIMETHYL-1,2,3,3A,5,9B-HEXAHYDRO-4H-PYRROLO[3,4-C][1,6]NAPHTHYRIDIN-4-ONE'>7C6</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tin\|5tin]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tio OCA], [http://pdbe.org/5tio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tio RCSB], [http://www.ebi.ac.uk/pdbsum/5tio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tio ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN]] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, H]]
	[[Category: Huang, X]]		[[Category: Huang, X]]
-	[[Category: ~~Chen~~, H]]	+	[[Category: Shaffer, P L]]
-	[[Category: ~~Shaffer, P.L~~]]	+	[[Category: Ligand-gated ion channel neurotransmitter receptor membrane protein cys-loop receptor]]
		+	[[Category: Transport protein]]

OCA: Protected "5tio" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2016 15:52:27 GMT

Protected "5tio" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:52, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tio is ON HOLD until Paper Publication Authors: Shaffer, P.L., Huang, X., Chen, H. Description: Crystal Structure of Human Glycine Receptor alpha-...

OCA — Wed, 19 Oct 2016 15:52:26 GMT

New page: '''Unreleased structure''' The entry 5tio is ON HOLD until Paper Publication Authors: Shaffer, P.L., Huang, X., Chen, H. Description: Crystal Structure of Human Glycine Receptor alpha-...

New page

'''Unreleased structure'''

The entry 5tio is ON HOLD until Paper Publication

Authors: Shaffer, P.L., Huang, X., Chen, H.

Description: Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607
[[Category: Unreleased Structures]]
[[Category: Huang, X]]
[[Category: Chen, H]]
[[Category: Shaffer, P.L]]