5tiy - Revision history

OCA at 13:03, 4 October 2023

OCA — Wed, 04 Oct 2023 13:03:01 GMT

←Older revision		Revision as of 13:03, 4 October 2023
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	<StructureSection load='5tiy' size='340' side='right'caption='[[5tiy]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='5tiy' size='340' side='right'caption='[[5tiy]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tiy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tiy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TIY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=OAQ:{(2S)-7-NITRO-2-[(PROPAN-2-YLAMINO)METHYL]-1,2,3,4-TETRAHYDROQUINOLIN-6-YL}METHANOL'>OAQ</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.76Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tiv\|5tiv]], [[5tiw\|5tiw]], [[5tix\|5tix]], [[5tiz\|5tiz]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=OAQ:{(2S)-7-NITRO-2-[(PROPAN-2-YLAMINO)METHYL]-1,2,3,4-TETRAHYDROQUINOLIN-6-YL}METHANOL'>OAQ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tiy OCA], [~~http~~://pdbe.org/5tiy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tiy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tiy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tiy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tiy OCA], [https://pdbe.org/5tiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tiy RCSB], [https://www.ebi.ac.uk/pdbsum/5tiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tiy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A094ZWQ2_SCHHA A0A094ZWQ2_SCHHA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:

	==See Also==		==See Also==
-	*[[Sulfotransferase\|Sulfotransferase]]	+	*[[Sulfotransferase 3D structures\|Sulfotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hart, P J~~]]	+	[[Category: Schistosoma haematobium]]
-	[[Category: ~~Taylor, A B~~]]	+	[[Category: Hart PJ]]
-	[[Category: ~~Helminth]]~~	+	[[Category: Taylor AB]]
-	~~[[Category: Oxamniquine]]~~	+
-	~~[[Category: Parasite]]~~	+
-	~~[[Category: Sulfotransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:12, 23 September 2020

OCA — Wed, 23 Sep 2020 12:12:02 GMT

←Older revision		Revision as of 12:12, 23 September 2020
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	==Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex==		==Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex==
-	<StructureSection load='5tiy' size='340' side='right' caption='[[5tiy]], [[Resolution\|resolution]] 1.76Å' scene=''>	+	<StructureSection load='5tiy' size='340' side='right'caption='[[5tiy]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tiy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tiy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TIY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=OAQ:{(2S)-7-NITRO-2-[(PROPAN-2-YLAMINO)METHYL]-1,2,3,4-TETRAHYDROQUINOLIN-6-YL}METHANOL'>OAQ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=OAQ:{(2S)-7-NITRO-2-[(PROPAN-2-YLAMINO)METHYL]-1,2,3,4-TETRAHYDROQUINOLIN-6-YL}METHANOL'>OAQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tiv\|5tiv]], [[5tiw\|5tiw]], [[5tix\|5tix]], [[5tiz\|5tiz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tiv\|5tiv]], [[5tiw\|5tiw]], [[5tix\|5tix]], [[5tiz\|5tiz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tiy OCA], [http://pdbe.org/5tiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tiy RCSB], [http://www.ebi.ac.uk/pdbsum/5tiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tiy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tiy OCA], [http://pdbe.org/5tiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tiy RCSB], [http://www.ebi.ac.uk/pdbsum/5tiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tiy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5tiy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tiy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sulfotransferase\|Sulfotransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hart, P J]]		[[Category: Hart, P J]]
	[[Category: Taylor, A B]]		[[Category: Taylor, A B]]

OCA at 08:28, 3 August 2017

OCA — Thu, 03 Aug 2017 08:28:32 GMT

←Older revision		Revision as of 08:28, 3 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tiy is ~~ON HOLD until Paper~~ Publication	+	==Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex==
		+	<StructureSection load='5tiy' size='340' side='right' caption='[[5tiy]], [[Resolution\|resolution]] 1.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tiy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TIY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=OAQ:{(2S)-7-NITRO-2-[(PROPAN-2-YLAMINO)METHYL]-1,2,3,4-TETRAHYDROQUINOLIN-6-YL}METHANOL'>OAQ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tiv\|5tiv]], [[5tiw\|5tiw]], [[5tix\|5tix]], [[5tiz\|5tiz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tiy OCA], [http://pdbe.org/5tiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tiy RCSB], [http://www.ebi.ac.uk/pdbsum/5tiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tiy ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The antischistosomal prodrug oxamniquine is activated by a sulfotransferase (SULT) in the parasitic flatworm Schistosoma mansoni. Of the three main human schistosome species, only S. mansoni is sensitive to oxamniquine therapy despite the presence of SULT orthologs in Schistosoma hematobium and Schistosoma japonicum The reason for this species-specific drug action has remained a mystery for decades. Here we present the crystal structures of S. hematobium and S. japonicum SULTs, including S. hematobium SULT in complex with oxamniquine. We also examined the activity of the three enzymes in vitro; surprisingly, all three are active toward oxamniquine, yet we observed differences in catalytic efficiency that implicate kinetics as the determinant for species-specific toxicity. These results provide guidance for designing oxamniquine derivatives to treat infection caused by all species of schistosome to combat emerging resistance to current therapy.

-	~~Authors:~~ Taylor, ~~A.B.~~, ~~Hart~~, P.J.	+	Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.,Taylor AB, Roberts KM, Cao X, Clark NE, Holloway SP, Donati E, Polcaro CM, Pica-Mattoccia L, Tarpley RS, McHardy SF, Cioli D, LoVerde PT, Fitzpatrick PF, Hart PJ J Biol Chem. 2017 Jul 7;292(27):11154-11164. doi: 10.1074/jbc.M116.766527. Epub, 2017 May 23. PMID:28536265<ref>PMID:28536265</ref>

-	~~Description: Schistosoma haematobium (Blood Fluke) Sulfotransferase~~/S~~-oxamniquine Complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Hart, P.J]]	+	<div class="pdbe-citations 5tiy" style="background-color:#fffaf0;"></div>
-	[[Category: Taylor, A.B]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hart, P J]]
		+	[[Category: Taylor, A B]]
		+	[[Category: Helminth]]
		+	[[Category: Oxamniquine]]
		+	[[Category: Parasite]]
		+	[[Category: Sulfotransferase]]
		+	[[Category: Transferase]]

OCA at 13:34, 9 March 2017

OCA — Thu, 09 Mar 2017 13:34:54 GMT

←Older revision		Revision as of 13:34, 9 March 2017
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	Description: Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex		Description: Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Taylor, A.B]]
	[[Category: Hart, P.J]]		[[Category: Hart, P.J]]
		+	[[Category: Taylor, A.B]]

OCA at 17:06, 26 October 2016

OCA — Wed, 26 Oct 2016 17:06:52 GMT

←Older revision		Revision as of 17:06, 26 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tiy is ON HOLD	+	The entry 5tiy is ON HOLD until Paper Publication

	Authors: Taylor, A.B., Hart, P.J.		Authors: Taylor, A.B., Hart, P.J.

OCA: Protected "5tiy" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2016 15:53:55 GMT

Protected "5tiy" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:53, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tiy is ON HOLD Authors: Taylor, A.B., Hart, P.J. Description: Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex [[Categ...

OCA — Wed, 19 Oct 2016 15:53:54 GMT

New page: '''Unreleased structure''' The entry 5tiy is ON HOLD Authors: Taylor, A.B., Hart, P.J. Description: Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex [[Categ...

New page

'''Unreleased structure'''

The entry 5tiy is ON HOLD

Authors: Taylor, A.B., Hart, P.J.

Description: Schistosoma haematobium (Blood Fluke) Sulfotransferase/S-oxamniquine Complex
[[Category: Unreleased Structures]]
[[Category: Taylor, A.B]]
[[Category: Hart, P.J]]